Biomedical subjects
B GUNNING
Publications and source records attributed to B GUNNING.
Liver pyridine nucleotide synthesis in the vitamin B6-deficient rat.
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Effects of natural and hydrogenated fats of approximately equal dilenoic acid content upon plasma lipids.
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Observations concerning the production and excretion of cholesterol in mammals. IX. The mechanism of the hypercholesteremic effect of cholic acid.
Accumulation of cholate in plasma is the immediate cause of hypercholesteremia in the rat with bile duct ligation and in the normal rat given intravenous sodium cholate. The hypercholesteremia induced by cholate administration does not appear to be dependent upon any preceding change in the rates of absorption, excretion, synthesis, or redistribution of cholesterol in the tissues of the animal. Cholate administration seems to induce hypercholesteremia by impeding the normal rate of passage of cholesterol from the plasma into the liver; this impedance is probably due to an alteration of the cholesterol-binding power of plasma proteins induced by cholate. The chemical and physiological implications of this finding are discussed.
Observations concerning production and excretion of cholesterol in mammals. VIII. Fate of injected cholesterol in the animal body.
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Observations concerning the production and excretion of cholesterol in animals. XI. The intestinal site of absorption and excretion of cholesterol.
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