Obesity in an 18-year-old boy with untreated celiac disease.
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Biomedical subjects
Publications and source records attributed to B Garanty-Bogacka.
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The aim of the study was to determine serum concentration and urinary excretion of selected parameters of bone metabolism in boys with constitutional delay of growth and puberty (CDGP) in the relation to pubertal stages. The study group consisted of 41 boys (aged 8 to 18 yrs) with CDGP. Patients were divided on the basis of Tanner's criteria into 4 groups according to the pubertal stage. Serum alkaline phosphatase (AP) activity and serum osteocalcin (OC) concentration as markers of bone growth, as well as urinary deoxypyridinoline (DPD) as a marker of bone resorption were determined. Serum AP activity in 31 (75.6%) boys was within normal age range. Mean values of serum AP activity increased insignificantly from I to IV stage of puberty. Serum OC concentrations were normal in 33 (80.5%) patients. Eight (19.5%) boys showed decreased values of serum OC concentration. Mean OC concentration insignificantly increased with the pubertal stages. DPD urinary excretion was within normal age range in all patients and was the highest in stage III of pubertal stage. No significant abnormalities of bone metabolism parameters in boys with constitutional delay of growth and puberty were found.
The frequency of the developmental dysfunction and specific learning disabilities were assessed in the retrospective study in the group of 56 school-aged twins. The relationships between genetic, perinatal and social factors and learning disability were also determined. It was found that 12.5% of twins had learning disabilities. The most common neurodevelopmental dysfunction were language disorders, poor graphomotor fluency and poor fine motor dexterity. It was also found that educational difficulty were associated with prematurity, low Apgar scores, neonatal complications and familial predisposition.
Longitudinal evaluation of development at the infantile period involved 415 children, born during the period from 1985.12.01 to 1987.03.31 in two Obstetric Clinics, PMA, in Szczecin. The studied group comprised 108 eutrophic premature infants, 25 premature babies with hypotrophy, 116 full-term neonates with intrauterine hypotrophy. The control group was made up of 166 infants born at term, being eutrophic neonates. Physical development was analyzed on the basis of measuring 13 anthropometric parameters, determined in monthly compartments. Evaluation of psychomotoric development was performed by the aid of Denver's test in the 3, 6, 9 and 12 month of life. The accomplished studies have disclosed that delays in physical and psychomotor development persisted still in the 12th month of life in children of the investigated group as compared with the control one. Retardations in somatic development were more pronounced in children with hypotrophy, while disturbances in psychomotor development were recorded more frequently in premature infants, and involved spheres of locomotion and visual-motorial coordination. In the studied population the achievements in children's development were significantly correlated with the degree of maturity after birth, and past infectious diseases. Among the environmental factors, an essential influence was exerted by the education of parents, social-existential conditions of the family as well as cigarette-smoking by the mother.