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Biomedical subjects

B Garber

Publications and source records attributed to B Garber.

At least 19 recordsLinked to original sources

Concurrent therapies: a model for collaboration between psychoanalysts and other therapists.

Many psychoanalysts treat individuals who are simultaneously in couples therapy or whose partners are in individual therapy. If such cases stall, some analysts may seek consultation from a colleague, though most have accepted the tacit historical prohibition against communication between therapists treating members of the same family. Experience, however, suggests that a certain form of communication between such therapists can have a powerfully enhancing effect on the concurrent therapies. After a review of the literature, the advantages, disadvantages, and impediments to collaborative cross-communication are examined. A model is then presented for use in ongoing discussion between therapists, and is illustrated with two clinical examples. The proposed model centers on the transference-countertransference configurations within the therapeutic field, and serves as an organizer highlighting areas for discussion.

Adult↗

Node-negative breast carcinoma treated without adjuvant systemic therapy.

In this prospective study, 167 consecutive patients with node-negative invasive breast cancer were treated without adjuvant systemic therapy in a community hospital from 1974 through 1984. The median follow-up for living patients was 84 months. Ninety-three percent of patients had disease classified as T1, N0, M0 or T2, N0, M0. Overall survival at 5 years was 81% and at 10 years, 66%. Adjusted survival rates, which excluded patients who died without breast cancer, were 91% at 5 years and 83% at 10 years. Relapse-free survival rates were 74% at 5 years and 61% at 10 years. T status, age, menopausal status, histology, estrogen receptor status, nuclear grade, and sinus histiocytosis were evaluated as prognostic indicators. It was difficult for the pathologists to assign a single value for nuclear grade; however, univariate analysis showed a significant difference in outcome between patients with nuclear grade 1 versus nuclear grade 4 lesions. Patient age is important in the decision regarding adjuvant therapy in that patients aged 70 and older are much more likely to die without breast cancer recurrence. By multivariate analysis, tumor size was the only independently significant factor (P less than .0125).

Adenocarcinoma↗

Altered behavioral response to apomorphine in cadmium exposed rats.

The present study investigated the hypothesis that changes in dopamine system functioning mediates cadmium induced hyperactivity. Two groups of twenty male Sprague-Dawley rat pups were treated with either 0.25 mg/kg of CdCl2 in saline or the saline vehicle only for ten consecutive days beginning on the fifth day of life. Beginning at 50 days of age, locomotor activity was recorded following each of three different doses of apomorphine HCl in saline or the saline vehicle only. Results indicated a significant cadmium by dose of apomorphine interaction when groups were first divided into high and low activity groups on the basis of baseline activity scores. These results are interpreted as indicating the existence of dopamine system supersensitivity in cadmium exposed animals. However, differences between treatment groups in baseline activity levels were not observed thus the relationship between alterations in DA system-functioning and Cd-induced hyperactivity could not be confirmed. In addition, a significant decrease in the body weights of Cd treated animals appeared approximately two weeks after the cessation of treatment and persisted through the testing period. Alternate hypothesis which might explain the observed behavioral differences are discussed.

Animals↗