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Biomedical subjects

B Garty

Publications and source records attributed to B Garty.

At least 19 recordsLinked to original sources
PubMed1995

The immunosuppressive human placental ferritin subunit p43 is produced by activated CD4+ lymphocytes.

Human placental ferritin is an immunosuppressive protein composed of a 43-kDa subunit (p43) and ferritin light chains. Its physiological action seems to be downregulation of the immune response of the mother against her embryo. Elevated levels of p43 in serum are associated with pregnancy, lymphomas, breast cancer, and AIDS. Although it is known that p43 is produced by activated T lymphocytes, the specific T-lymphocyte subset involved is unknown. p43 is measured by enzyme-linked immunosorbent assays with CM-H-9 monoclonal antibody specific for p43. We studied the de novo biosynthesis of p43 by isolated activated CD4+ and CD8+ T lymphocytes in a normal donor and in a patient with elevated levels of p43 in serum. The results indicated that p43 was synthesized by activated CD4+ lymphocytes from the normal donor (0.45% of the total de novo proteins) but that its biosynthesis by CD8+ lymphocytes was below the level of detection. The activated CD4+ lymphocytes from the patient with elevated levels of p43 in serum overproduced p43 (3.8% of the nascent proteins). Since it was shown that a subset of CD8+ lymphocytes has receptors for p43, the latter may be considered an immunoregulatory cytokine produced mainly by activated CD4+ lymphocytes.

Adolescent↗
PubMed1994

[Subdural empyema complicating sinusitis].

Paranasal sinusitis complicated by subdural empyema (SDE) in a 14-year-old boy is described. He presented with fever, headache and vomiting. X-rays revealed left maxillary and bilateral frontal sinusitis. While in the emergency room he had seizures; CT-scan showed an air leak adjacent to the right frontal sinus. Despite intravenous antibiotics, left hemiparesis developed and repeat CT showed interhemispheric SDE. Frontal craniotomy was performed and a large amount of purulent material was drained. Recovery followed 4 weeks of intravenous antibiotic treatment without neurologic sequelae. SDE is a rare complication of paranasal sinusitis and constitutes approximately 20% of all localized intracranial infections. Clinical features include fever, headache, vomiting, convulsions and neurologic deficits. Modern imaging methods and combined surgical and antibiotic treatment have lowered mortality to 5-10%. A high index of suspicion is important for early diagnosis and successful treatment.

Adolescent↗
PubMed1992

[Transient hyperphosphatasemia of infancy].

Transient hyperphosphatasemia of infancy was diagnosed in 4 children hospitalized during a 6-month period (0.3% of all hospitalized children). The characteristic features of this disorder are: 1. elevation of serum alkaline phosphatase (of both liver and bone origin) up to 3-30 times the upper limit of normal for age (usually discovered during intercurrent infection); 2. return of the serum alkaline phosphatase to normal in a few weeks; 3. no residual clinical or laboratory evidence of bone or liver disease. The child is usually less than 5 years old. Recognition of the benign nature of this disorder prevents extensive laboratory workup and unnecessary anxiety.

Alkaline Phosphatase↗
PubMed1987

T cell subsets in children with mumps meningitis.

Nineteen children with mumps meningitis were investigated. Peripheral blood T cell subset function and number were tested during the acute phase of meningitis and again when the children recovered. No significant difference in the total number of T cells, or T helper: suppressor lymphocyte cell ratio was found in the children with mumps meningitis as compared with the controls. However, a significant increase in the number of T suppressor/cytotoxic cells in the peripheral blood of children with mumps meningitis in the acute phase was found. This increase in the T suppressor subset was still present even after the children recovered from the disease. Two children who showed deafness had the highest increases in the T suppressor/cytotoxic lymphocyte subset. Functional analysis of T suppressor cell activity demonstrated a significant suppressive activity of lymphocytes obtained during the acute phase of the disease. However, after recovery the suppressive activity found was not significant (P greater than or equal to 0.1).

Child↗
PubMed1984

Familial multiple naevi flammei.

The third family with multiple naevi flammei and the first description of its occurrence in unidentical twins is presented. Autosomal dominant inheritance is confirmed.

Female↗
PubMed1983

[Leopard syndrome].

Explore the source record for details and available documents.

Abnormalities, Multiple↗