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Biomedical subjects

B Gentile

Publications and source records attributed to B Gentile.

35 records · Page 2Linked to original sources
PubMed1985

Aminoethers of (+)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-hydroxyimine with hypotensive activity.

The synthesis of beta-dialkylaminoethyl ethers (II a-f) and gamma-dialkylaminopropyl ethers (II g-i), as well as of aryl carbamates (III 1, m), starting from (+)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-hydroxyimine (I), is described. beta-Dimethylaminoethyl ether (II a) showed a remarkable hypotensive and bradycardic activity in rats; moreover, nearly all compounds (II) and (III) exhibited a weak antiarrhythmic activity in rats. Infiltration anesthesia in mice, beta-blocking activity in dogs and antiacetylcholine activity in vitro are also reported.

Acetylcholine↗
PubMed1985

Pharmacological properties of a new non-steroidal anti-inflammatory drug: flunoxaprofen.

The anti-inflammatory, analgesic and antipyretic activities of S-(+)-2(4-fluorophenyl)-alpha-methyl-5 benzoxazole acetic acid (flunoxaprofen: Flu), a new non-steroidal anti-inflammatory drug, were compared with those of indomethacin and other non-steroidal anti-inflammatory drugs (NSAIDs) in experimental animals. Flu showed strong inhibitory activity on acute and subacute inflammation tests in rats, such as carrageenin hind paw oedema (oral: 6-25 mg/kg; rectal: 50-100 mg/kg); pellet-induced granuloma formation (5-20 mg/kg/day) and adjuvant-induced arthritis (10 mg/kg/day). Its potency was comparable with that of indomethacin (I) and higher than that of acetyl salicylic acid (ASA), ibuprofen (IBU) or phenylbutazone (P). The analgesic activity of Flu, evaluated by the hot plate method and tail pinching in mice, was slightly lower than that of I but higher than that of ASA and IBU. In pyretic rabbits Flu showed an antipyretic activity higher than that of ASA and IBU. The ability of Flu to affect platelet aggregation, mucopolysaccharide synthesis by fibroblasts and the proteolytic action of trypsin was also investigated.

Animals↗
PubMed1985

2-Substituted-3-pyridinolethers as hypolipidemic and platelet aggregation inhibiting agents.

Some 2-substituted 3-pyridinolethers were synthesized, with one side chain bearing a carboxylic function; among these there are products having structure analogies with the prostaglandins. The results of hypolipidemic and hypocholesterolemic tests on experimental hyperdyslipidemic animals, as well as those on the inhibition of platelets aggregation and on fibrinolytic activity are reported.

Animals↗
PubMed1982

Epidemiology of leishmaniasis in French Guiana.

Lutzomyia umbratilis is confirmed as the vector of Leishmania braziliensis guyanensis, the cause of "pian bois" in man in French Guiana. Although spending most of the year in the forest canopy, this sandfly is abundant at ground level for about two weeks at the beginning of the long rainy season. The maximum number of infective bites per man per hour (3.9) was reached at the end of November 1979. Infections were found in one of seven Potos flavus, seven of 15 Choleopus didactylus and two of 19 rodents examined. C. didactylus seems likely to be the main reservoir.

Animals↗
PubMed1979

[Down syndrome: immunological study in adults (author's transl)].

The immunological profile was evaluated in 12 adults affected by Down's syndrome. Our findings showed: increase of serum IgG, IgA and Gammaglobulins, decrease of IgM, presence of auto-antibodies and increased antibodies response after antigenic stimulation (typhoid vaccination). Some tests, connected with T lymphocytes functions, were also abnormal: percentage of E-active rosettes, cutaneous sensibilization with DNCB and lymphocyte stimulation index with PHA. Our findings suggest a T lymphocyte deficit, with loss of immunological surveillance and therefore of the control over antibody mediated immunological reactions. The immunological alterations observed in our adult patients with Down's syndrome were more extensive and severe than those found in young subjects. The possible relevance of these findings is discussed as well as the incidence of Alzheimer's dementia in adult patients with Down's syndrome.

Adult↗
PubMedDate not supplied

[Hemorrhagic dengue fever: evidence of consumption coagulopathy (author's transl)].

Coagulation is explored in 129 children infected by dengue virus and presenting either banal symptoms, or an hemorrhagic fever. Results are given, and commented according to the disease's clinical staging. A disseminated intravascular coagulation symdrome is brought out in all the cases, but with less or more intensity, though it belongs to dengue virus infection. Etio-pathogenic mechanism is then discussed.

Adolescent↗