[Treatment results in ovarian sarcomas].
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Adult↗
Biomedical subjects
B Georgieva
Publications and source records attributed to B Georgieva.
[Changes in the biochemical indices in iron-deficiency erythropoiesis].
In 608 patients with iron-deficiency anemia the following indices were examined: serum iron, total iron-binding capacity, serum ferritin, hemoglobin, free protoporphyrin, reduced glutathione as well as the activity of porphobilinogen synthetase in the erythrocytes. Increased of free protoporphyrin and of reduces glutathione as well as increased activity of porphobilinogen synthetase were found which the authors accept as an expression of iron-deficiency erythropoiesis. Serum ferritin was lowered but in many patients its level did not indicate totally exhausted iron reserves despite the well expressed anemia accompanied by a low serum iron level and transferrin saturation. In these patients an additional pathogenetic mechanism is supposed leading to retaining of some quantity of iron in the cells of the monocytic-macrophagal system.
Adult↗
[Extramedullary localization of acute leukemia. I. The involvement of the central nervous system].
The involvement of the central nervous system in acute leukemia was studied in 15 adult patient. 60% of the patients were up to 35 years of age and 12 of them (80%) were with acute lymphoblastic leukemia. In 12 of the patients the nervous system was affected in the acute course of the disease, in one female patients--in the course of induction treatment and in the remaining patients--after the induction treatment. The manifestations of neuroleukemia are predominantly meningoradicular irritation with headache--in 86.7% of the patients, diplopia, papilledema, dysarthria and palpebral ptosis with affection of the cranial nerves (III, IV, V, VI, VII, VIII, IX, XII). In 12 patients (87.5%) blast cells were found in the cerebrospinal fluid in numbers ranging from 70 up to 36,000/mm3. In 26.7% of the patients other extramedullary localizations of leukemia were found parallelly (testes, thyroid gland hypopharynx, muscles). The application of methotrexate intrathecally and radiation therapy of the cranium led to a remission in 43% of the patients. Favourable results with considerably prolonged survival can be achieved also in patients with many recurrences of the disease. The need of neuroleukemia prophylaxis is proved (it is obligatory for the patients with acute lymphatic leukemia and with some forms of acute myeloblastic leukemia).
Adult↗
[Functional criteria for the differentiation of leukemic cells. II. The fungicidal activity of the blast cells from patients with acute monoblastic leukemia].
The studies in the present work are a continuation of the previous studies of the author's on the functional activity of leukosis cells and discuss their fungicidal activity versus Candida albicans. Blast cells from 22 patients with various clinical-morphological forms of acute leukosis were studied. It has been concluded from the results obtained that leukosis cells of monoblast type in acute myelomonoblast (M4) and monoblast (M5) leukosis are able to lyse Candida albicans, the value of their fungicidal activity being lower than that of mature monocytes from peripheral blood of healthy subjects. The fungicidal activity is observed in leukosis cells from patients with promyelocyte (M3) leukosis. The authors propose the fungicidal activity of leukosis cells to be used as an additional, functional criterium in the differentiation of their type.
Blood Bactericidal Activity↗
[Invasive aspergillosis in patients who died from acute leukemia].
The necropsy material with acute leukosis (166 deceased) was studied in order to establish the incidence of invasive aspergillosis. It was established in 16 of the deceased (9,64%): aspergillosis pneumonia--in 5 cases, aspergillosis sepsis--in II, with invasion of lungs, brain, spleen, liver, myocardium and other organs. Clinically aspergillosis was not distinguished. Continuous septic temperature, not influenced by antibiotic therapy should draw the attention to the presence of aspergillosis. The factors, preconditioning aspergillosis infection are stressed upon: immune-suppressive treatment in acute leukosis, granulocytopenia, continuous preceding antibiotic therapy, etc. The difficulties in the clinical differentiation of the infection are emphasized. With a view to the high incidence and lethality of aspergillosis in acute leukosis, the introduction of modern diagnostic methods and treatment are underlined to be necessary.
Acute Disease↗
[Thrombotic thrombocytopenic purpura (Moschkowitz's disease)--a review of the literature with a case report].
A case with thrombotic thrombocytopenic purpura (TTP) in a young female is described. The clinical picture is described as well as the pathologoanatomical finding, the characteristic and pathognomonic sins of the disease being mentioned. A survey of the literature is made, covering data about the thorough characteristic of the disease--clinical-laboratory, pathomorphological picture, etiological and pathogenetic aspects. Attention is paid to the laboratory discrepancies with the syndrome of disseminated intravascular coagulation, included in the differential diagnosis when making the clinical diagnosis of TTP. The success in the treatment of TTP during the last several years is reported with the introduction of combined therapy with corticosteroids, splenectomy, antiaggregating thrombocyte agents, exsanguination transfusion and, with the most reliable effect for the present--plasmapheresis and plasmainfusions.
Adult↗
[Functional criteria for differentiating blast cells in acute leukemia].
Eighty nine patients were examined that had various clinical-morphological forms of acute leukosis, the phagocytic activity of leukosis cells being determined and the synthesis and secretion of lysozyme by them followed up, reflected in its serum level. Leukosis cells of monoblast type were established to have the ability to ingest staphylococci, candida and particles of latex, as well as to synthesize lysozyme, confirmed by the highly elevated enzyme quantity in the sera of the patients. Those functional manifestations are proposed to be used as additional criteria in the determination of cellular type of leukosis proliferation.
Acute Disease↗
[Effect of various cytostatics and radiotherapy on serum iron and copper levels in lymphoma patients].
Forty four patients with lymphoma, active stage, were examined. Polychemotherapy (PChTh), one course in various combinations of drugs were applied to 32 of them and to 18--radical beam therapy (above and under diaphragmal). Low iron and high copper in serum was found in all patients prior to treatment. Elevated serum iron (SI) was found in the patients after the course of PChTh, whereas the values of copper were almost unaffected. In the patients, after radical beam therapy, SI and serum copper tended to normalization, in parallel with the abating of the morbid process. The effect of cytostatics upon the SI level is discussed as well as the necessity of parallel determination of some other indices, serum copper in particular, in the assessment of the activity of the morbid process.
Antineoplastic Agents↗
[Reduced glutathione and porphobilinogen synthase activity in the erythrocytes of anemic patients with low serum iron].
Patients with iron deficiency anemia (IDA) were examined as well as patients with active lymphoma with low serum iron (SI) and anemia prior to treatment. Increased content of reduced glutathione (GSH) was found in the patients with IDA as well as enhanced activity of PBG-S in erythocytes, in parallel with the decreased SI and saturation rate of transferrins (SRT) and enhanced total iron-binding capacity (TIBC) in serum. In lymphoma patients a normal GSH content is found as well as normal PBG-S activity in erythocytes, low content of iron, SRT level and decreased TIBC in serum. The connection of SH groups with the level of serum iron is discussed.
Anemia, Hypochromic↗
Infectious complications and host immune defense in acute leukemia.
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Adolescent↗
[Diagnostic difficulties in symptomatic erythrocytosis developing in congenital heart defects].
A case with symptomatic erythrocytosis in a female patient with ductus Botalli persistens is described, diagnosed and treated as erythremia vera. The heart disease advanced with no manifestations, with no complaints until the age of 30, whereon it was manifested with certain complaints and objective findings. The inadequate and difficult assessment of some of the clinical, hematological and other data as X-ray of the heart and ECG, contributed to the improper diagnosis. The patient died at the age of 54.
Diagnosis, Differential↗
[Case of an unusual initial localization of a malignant lymphoblastic lymphoma].
A case is presented with lymphosarcoma and generalization of the process, with an atypical initial localization of the tumour in the gluteal regions. The grounds for admittance of the extranodal origination is the rather long period of time (10 months) after the initial manifestation of the tumour till the following generalization, accompanied by a deterioration of the patient's state.
Aged↗
[Clinical, morphological, cytochemical and ultrastructural studies of a female patient with basophilic leukemia].
The morphological, cytochemical and ultrastructural characteristics of basophilic cells in patients with chronic myeloleukosis were studied. The basophilic elements, dynamically followed up, from all phases of maturation, represented from 48 to 83 per cent of the cellular population in the peripheral blood and marrow. The cytochemical and ultrastructural investigations confirmed their belonging to the basophilic line. Certain changes were found, being an evidence of disorders in the maturation and metabolism of the cells. The high basophilic index, combined with a low neurophilic one, suggest the participation of the basophilic line in the leukosis process. On the base of the results obtained, the conception of the existence of basophilic leukosis is admitted.
Adult↗
[Bone manifestations of multiple plasmacytoma].
A case of multiple plasmocytoma in a women is described, with a several-year radicular syndrome and, recently, with numerous pathologic fractures and tumour formations on the head and sternum. The problem of bone pains, pathologic fractures and tumours -- osseous manifestations of the diseases are discussed.
Bone Neoplasms↗
[Infectious complications in acute and chronic leukemias].
Clinical and microbiological examinations of patients with acute leucosis and chronic myelo- and lympholeucosis were carried out aiming at the elucidation of incidence, localization and causative agents of the infectious diseases along with them. The infectious complications were concluded to present a serious problem in the treatment of leucosis, due to which their diagnosis is of essential importance for their early diagnosis, timely treatment and prophylaxis.
Bacterial Infections↗
[Glucose-6-phosphate dehydrogenase and pyruvate kinase activity and the content of adenosine triphosphate in the erythrocytes of leukemic patients].
The activity of G-6PD and PK in erythrocytes and ATP content in erythrocyte hemolysate in patients with leucosis (acute, chronic myelo- and chronic lympholeucosis) was investigated. A reduced G-6PD activity was found in the majority of the patients examined, being most markedly manifested in the patients with chronic lympholeucosis and least--in the patients with chronic myeloleucosis. About 50 per cent of the patients with acute leucosis and chronic lympholeucosis have reduced PK activity and in those with chronic myeloleucosis -- increased. ATP content is increased in patients with chronic myeloleucosis and in the rest of the patients -- normal. A disturbance of glucose metabolism in erythrocytes in patients with leucosis is concluded to exist.
Acute Disease↗
[Copper and magnesium in the plasma and erythrocytes in leukemic patients].
Copper and magnesium in plasma and erythrocyte hemolysate were investigated of leucosis patients: acute and chronic (myelo-and lympholeucosis) in an active stage. In all patients, elevated average values of copper in plasma were established as compared with the controls (p greater than 0.05), being the highest in patients with lympholeucosis. Copper in erythrocyte hemolysate was not elevated in all three kinds of leucosis as compared with the controls (p greater than 0.05). Plasma magnesium was elevated in the patients with acute leucosis and chronic lympholeucosis, whereas in erythrocyte hemolysate, magnesium values were elevated in all three kinds of leucosis (p less than 0.05). The elevation of copper in plasma is associated with the malignant process and the elevation of magnesium in erythrocytes -- with a changed erythrocyte metabolism in leucosis patients.
Acute Disease↗
[Changes in serum iron, total iron-binding capacity and cytological indices in pregnant women with an anemic syndrome].
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Anemia, Hypochromic↗