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Biomedical subjects

B Gessner

Publications and source records attributed to B Gessner.

14 recordsLinked to original sources
PubMed2004

[Results of pars plana lensectomy for childhood cataract].

BACKGROUND: Pars plana lensectomy with subsequent fitting of contact lenses is the standard procedure for cataracts occurring within the first 2 years of life. We wanted to assess the outcome and complication rate of this procedure. METHODS: Pars plana lensectomy was performed on 29 eyes of 15 children with bilateral as well as 12 eyes with unilateral cataracts. All children were reexamined at an age of at least 3 years. RESULTS: In bilateral cases the mean age at the time of surgery was 4.0 months and mean resulting visual acuity 0.32. After exclusion of three eyes with complications or bad postoperative compliance, we found a statistically significant correlation between age at surgery and visual acuity (r(2)=0.432, p<0.05). Some form of binocular vision was achieved by 40% of the children; 17% developed ocular hypertension and 7% a secondary cataract. In the unilateral cases the mean age at surgery was 3.9 months and the mean resulting visual acuity 0.14. There was no significant correlation between age and visual acuity; 17% gained binocular function and 5% had ocular hypertension. CONCLUSION: Visual function after lensectomy is better in eyes with bilateral cataracts compared to unilateral cataracts. Early surgery as well as adequate orthoptic therapy and compliance with wearing the contact lens are necessary for good outcome.

Cataract↗
PubMed1992

[Dextrose and vigilance: the effect of dextrose on the spectro-analytic parameters of pharmaco-EEG].

In a randomized single-blind cross-over-design the effect of 15 g dextrose was investigated against placebo with 48 healthy subjects at two different days each. The quantitative pharmaco-EEG was recorded occipitocentral at the left side (O1-Cz) under vigilance controlled conditions and then under resting conditions (three minutes each). Having measured its baseline it was repeated six times every 20 minutes starting 10 minutes after the application of the substance. After the administration of dextrose a stabilization of vigilance could be seen in the EEG by the following differences of statistical significance (p < = 0.05) between dextrose and placebo under resting recording conditions: In the first control (14.-16. minute post) there was a significant decrease of the relative power in the delta and in the theta range combined with an increase of alpha 2. In the second control (34.-36. minute post) there was a significant decrease of relative power in the theta range and significant increase in the alpha 1 range. In the third control (54.-56. minute post) and later on no effects of dextrose were left in the pharmaco-EEG. The significant differences in the first and second control have to be interpreted as follows: After the administration of dextrose the level of vigilance was increased compared to the placebo group.

Adult↗
PubMed1985

Study of the long-term action of a Ginkgo biloba extract on vigilance and mental performance as determined by means of quantitative pharmaco-EEG and psychometric measurements.

The action of a Ginkgo biloba extract (rökan, Tanakan, G.B.E.) in promoting blood flow has been demonstrated in several animal and human pharmacological studies. The aim of this present study was to estimate the action of the substance on the central nervous system in order to be able to assess its potential use as a therapeutic agent in geriatric patients with cerebral insufficiency. Quantitative pharmaco-EEG is the method of choice for studying the vigilance-promoting effects of a drug. It is incomparable for confirming the findings of behavioural and psychometric studies. 60 volunteers of either sex participated in the double-blind trial. They were aged 57-77 years and showed mental deterioration corresponding to their age. They were randomly divided into three experimental groups: 20 subjects received 3 X 40 mg/day G.B.E., 20 received 5 mg nicergoline and 20 received a placebo of similar appearance. The subjects underwent an extensive series of examinations before and 4, 8 and 12 weeks after the start of medication. Analysis of the EEG results for the whole group revealed no significant advantage of G.B.E. over the two reference substances with regard to vigilance. However, a subclassification of the subjects showed that the vigilance of those persons with a more unfavourable initial situation measured in the resting EEG could be clearly improved by chronic G.B.E. medication. This increase in vigilance was reflected at the behavioural level by an improvement of reaction times in the G.B.E. group by comparison with the reference substances.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1984

[Studies on the effect of Harmonicum Much on sleep using polygraphic EEG recordings].

The effects of 60 and 120 mg valerian (1 resp. 2 capsules Harmonicum Much) have been investigated by computer analysis of sleep stages (sleep profiles) and psychometric methods ( questionnaires ). EOG, EMG of cervical muscles, ECG and EEG (two-sided: centro-occipital and fronto-central - have been recorded from 6 male and 5 (3) female healthy volunteers. Amplified signals have been analysed on-line (power spectral analysis) and the sleep profiles have been calculated accordingly. After one night for adaptation, each subject took orally placebo, 60 and 120 mg valerian (1 resp. 2 capsules Harmonicum Much) according to a randomized double-blind repeated measures-design. The sleep investigations have been carried out by distance of a week for each condition (dosage per subject). In the morning following this night, the subjects completed a mood scale. Both dosages showed a decrease of sleep stage 4 and a slight reduction of REM-sleep. Contrary, a slight increase of sleep stage awake, 1 and 2 could be observed. A further increase of sleep stage 3 could be identified. After application of 120 mg valerian , the frequency of REM-phases (in %) declined during the first half of the night, whereas during the second part of the night, a surplus appeared. Changes or the Beta-intensity of the EEG during REM-sleep show a stronger hypnotic effect for the 120 mg dosage than for 60 mg. Maximum effect was observed between 2 and 3 hours post medicationem . Results of the mood scale are indifferent between the experimental conditions, which indicate no negative (side-) effects neither by drug nor by testing methods.

Adult↗
PubMed1982

[Influence of a Pentifylline-Nicotinic Acid Combination on Vigilance and Mental Performance (author's transl)].

The effect of a single dose of 4 sugar-coated tablets of Cosaldon (1-hexyl-3,7-dimethylxanthine (pentifylline) + nicotinic acid) was shown by quantitative pharmaco-EEG investigations and psychometric tests in 12 volunteers aged 58 to 75 years, who were in a good physical condition. The design was randomized, double-blind and cross-over designed against placebo. EEG and psychometric tests were made before medication and repeated each hour up to 6 h after medication. Each turn was split up into a resting-EEG (R-EEG) and a vigilance-EEG (V-EEG) lasting 3 min each; the psychometric tests were made immediately afterwards. An increase of the vigilance, shown by an increased EEG-power, was found after Cosaldon administration as compared to placebo. Furthermore, the delta and theta intensity decreased to a statistically significant degree, while the intensity within the alpha-1-scope increased. The strongest effect as compared to placebo could be observed 4 h after medication. The statistical significance was shown for the V-EEG-condition, the R-EEG showed only minor changes. The effects in the occipital region were stronger than in the more frontal parts. In accordance with the results of the EEG, the psychological tests showed remarkable improvements in performance which reached their maximum between 2 and 4 h after medication.

Aged↗
PubMedDate not supplied

Developing collaborative partnerships in continuing nursing education: walking the talk.

The purpose of this article is to describe and analyze a reciprocal partnership developed among four university-based continuing education providers in Wisconsin. Members of this partnership collaborated in developing a statewide program to address the educational needs of nurses moving from acute or long-term care into community nursing. Components of the reciprocal partnership model were applied in developing this program. The partners identified that, despite the initial time investment, the collaborative approach was an advantage. The collaborative approach enhanced the quality of the program developed and reached a wider audience. Continuing nursing educators may want to consider partnership arrangements for program development and implementation.

Community Health Nursing↗