Biomedical subjects
B Gniazdowska
Publications and source records attributed to B Gniazdowska.
Delayed contact hypersensitivity to non-steroidal anti-inflammatory drugs.
Several non-steroidal anti-inflammatory drugs (NSAIDs) are available for topical treatment of acute soft tissue trauma or degenerative musculoskeletal disorders; the NSAID bufexamac is mainly used for therapy of chronic inflammatory skin diseases. In order to assess the occurrence of contact allergy to NSAIDs in 371 consecutive patients presenting for diagnosis of presumed contact allergy, patch tests were performed with a standard series and additionally with a series of NSAIDs, comprising acetylsalicylic acid, bufexamac, diclofenac, etofenamate, felbinac, flufenamic acid, ibuprofen, indomethacin, and piroxicam. 17 individuals (4.6%) exhibited delayed hypersensitivity to one of the NSAID preparations: 12 patients (3.2%) had patch test reactions to bufexamac, 2 (0.5%) to etofenamate, 2 (0.5%) to indomethacin, and 1 patient (0.3%) to flufenamic acid. These patch test results corresponded well to the individual history in 11 individuals (including 10 patients with reactions to bufexamac), and in 2 patients the clinical relevance of the reactions was probable. In view of the high frequency of allergic contact reactions to bufexamac, we propose to test this drug particularly in patients with atopic eczema or other chronic eczematous diseases.
Allergic contact dermatitis from delta-aminolevulinic acid used for photodynamic therapy.
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[Hypersensitivity to weed pollen allergens in the region of Bygdoszcz].
Case records of 8576 patients suffering from hypersensitivity symptoms within upper airways, who were treated at the Otolaryngological Section of the Allergological Outpatient Department of Medical Academy in Bydgoszcz in the years 1975-1989, were analysed. Pollinosis was diagnosed through anamnesis, physical examination and skin tests in 2561 (29.9%) individuals, i.e. 1153 women and 1408 men. Hypersensitivity to weed pollen allergens was found in 1069 (12.5% of all people examined) patients with pollinosis, i.e. 487 women and 582 men. There were 941 (88%) inhabitants of urban and 128 (12%) of rural areas among them. Positive family history of allergic diseases was proved in 616 (57.6%) persons. Mean age at the first visit to the doctor was 28 years for women and 23 years for men, while mean age of weed pollinosis onset was 22 years for women and 17 years for men. The disturbances observed in patients sensitive to weeds were provoked mainly by wormwood (86.2%), mugwort (82.9%), white goosefoot (44.3%), narrow-leaved plantain (28.8%), and sheep sorrel (19.0%). Hypersensitivity to grass, tree and/or shrub pollens coexisted in 85.5% of patients with weed pollen allergy and 64.5% of them were also hypersensitive to several non-seasonal allergens in various combinations. Bronchial asthma was recognized in 101 (9.4%) patients with weed pollinosis, while allergic skin reactions were seen in 315 (29.5%) individuals.
[Epidemiologic studies on allergic diseases among rural and urban school children in Poland].
451 rural children (group I) and 2000 urban children (group II) aged 10-16 years from Toruń province were inquired by a questionnaire to their parents or guardians. 9.09% of children in the country and 13.45% of those living in the city of Toruń suffered from hypersensitivity disorders; bronchial asthma was reported in 2.22% and 3.05% of cases, allergic rhinitis--in 3.77% and 7.15%, allergic conjunctivitis--in 1.33% and 2.75%, allergic edema--in 0.44% and 0.60%, urticaria--in 1.55% and 3.50%, and infantile eczema--in 0.44% and 2.10% of cases, respectively. The pollinosis prevalence rate was 2.00% in group I and 1.85% in group II. At least 2 various forms of hypersensitivity coexisted in 30.48% of allergic urban children (64.86% of patients with pollinosis among them); infantile eczema preceded allergic rhinitis and bronchial asthma symptoms in 6.29% and 11.47% of cases, respectively, while allergic rhinitis occurred before the onset of bronchial asthma in 24.59% of asthmatic children. 37.10% of individuals with positive family history of allergic conditions also fell ill with some diseases of this nature, while in those with negative family history allergy occurred only in 10.22% of cases. From environmental factors mother's diseases during pregnancy, bottle feeding and a regular diet during the first year of life, frequent respiratory infections in the early childhood and poor living conditions increased the risk of allergic diseases or aggravated their course in the population examined.
[Desensitization at the first stage of IGE-mediated response as hay fever prophylaxis].
The aim of our work was to assess the prophylactic aspects of desensitization at the first stage of IgE-mediated response to grass pollen antigens (GPA). Forty six patients aged 10-45 (Me = 20.45) years (group I) and 50 patients aged 11-45 (Me = 19.17) years (group II) were included in to the study. All of them: 1) suffered from allergic rhinitis due to house dust (HD), feathers (F), weed (W) or tree (T) pollen, 2) had also some other allergic diseases, 3) had positive family history of allergic disorders, 4) had reproducible, strongly positive skin reaction of type I to GPA, but 5) did not show any clinical symptoms of hypersensitivity to GPA. Specific immunotherapy with HD, F, W, and T aqueous extracts was administered to both groups for at least 3 successive years, while parallel desensitization with GPA aqueous extract was carried out in group I, only. The symptoms of grass pollinosis were searcher for and the effects of immunotherapy were evaluated in all the patients over the period of at least 5 successive years after the complete course of vaccines administration. Clinical signs of hypersensitivity to GPA became evident in 6 patients (13.04%) of group I and in 27 patients (54.00%) of group II (p less than 0.001). Thus the desensitization at the first stage of IgE-mediated response to GPA effectively prevented development of the symptomatic hay fever. However, the disease revealed itself in few cases still much later and its course was much milder than in people who were not subjected to such a preventive desensitization.(ABSTRACT TRUNCATED AT 250 WORDS)
[Allergic diseases among students of the Medical Academy in Gdańsk. Epidemiological aspects].
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