Biomedical subjects
B Golden
Publications and source records attributed to B Golden.
Aberrant bacterial forms from various ocular sites.
Patients may harbor cell-wall-deficient organisms or other aberrant bacterial forms (ABFs) in their eyes. In this survey of 400 cultures, we found the incidence of ABFs isolated from various ocular sites to be 13.2%. The rate of isolation of these forms from the eyes of patients with suspected bacterial infection differed greatly from that for noninfected eyes. We will describe the microbiological techniques employed and will present our analysis of the data obtained.
Ocular penetration of topically applied gentamicin.
The biologically available concentration of gentamicine sulfate in eight ocular tissues of 140 rabbits and 96 humans was measured by a modified disc diffusion technique. If enough topically administered gentamicine was applied, this bioassay detected it in all ocular tissues tested except the lens nucleus. The decay of antibiotic activity was faster in some tissues, eg, aqueous, than in others. A higher level of antibiotic was found in corneas altered by sutures than in virgin tissue. The degree of inflammation, the frequency of application, and the interval between the drops are directly proportional to the antibiotic level in the tissues. The antibiotic free vehicle of commercial 0.3 per cent gentamicin drops possesses an antibacterial potential.
Comparison of antibiotic therapy in presumptive bacterial conjunctivitis.
One hundred twenty patients who met criteria for presumptive bacterial infections of the conjunctiva were closely recorded for two weeks in a double-blind study that compared the effectiveness of gentamicin with a combination of neomycin and polymyxin B sulfates. The neomycin and polymyxin B combination demonstrated statistical superiority as measured by patient improvement and failure to respond to therapy. However, difficulties including chance distribution of bacteria and variability of organism resistance may have detracted from statistical results.
Letter: Epidemic haemorrhagic conjunctivitis.
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Statistical correlation of uveitis syndromes with virus titers.
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Task force administrative structure. A new approach to staff deployment.
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A hazard of high rise buildings.
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Neonatal inclusion conjunctivitis. A report of three cases and a discussion of differential diagnosis and treatment.
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Pseudomonas corneal ulcers in contact lens wearers. Epidemiology and treatment.
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Subtenon injection of gentamicin for bacterial infections of the eye.
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Erythema multiforme exudativum (Stevens-Johnson syndrome) in association with Mycoplasma pneumoniae.
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Antibiotic concentration in ocular tissues. Penicillin G and dihydrostreptomycin.
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Enhancement of the infectivity titer of adenovirus type 8.
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Ocular tissue absorption of gentamicin.
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