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Biomedical subjects

B Goldner

Publications and source records attributed to B Goldner.

At least 19 recordsLinked to original sources
PubMed2001

Lead- and device-related complications in the antiarrhythmics versus implantable defibrillators trial.

BACKGROUND: Implantation of transvenous implantable cardioverter defibrillators (ICDs) by use of a nonthoracotomy approach has become routine therapy for survivors of life-threatening tachyarrhythmias. The purpose of this study was to identify and prospectively characterize the frequency of lead- and ICD-related complications from the Antiarrhythmics versus Implantable Defibrillators (AVID) Trial. METHODS AND RESULTS: Between June 1, 1993, and April 7, 1997, 539 patients received nonthoracotomy ICDs either as initial treatment assignment (477) or as crossover from medical management (62). A total of 62 first complications occurred. The subclavian route of insertion resulted in more complications than the cephalic vein route, 46 of 339 (14%) versus 6 of 135 (4%), P = .005, as did the abdominal versus pectoral generator site, 31 of 238 (13%) versus 17 of 291 (6%), P<.02. Most dislodgements and system infections tended to occur in the 3 months after implantation, whereas lead fractures continued to occur throughout follow-up. Failure to use perioperative antibiotics was a predictor of system infection (P = .001). CONCLUSIONS: These data suggest that cephalic vein access and pectoral generator site may result in fewer complications. The continued occurrence of lead fractures and the need for premature system revision supports the practice of close routine ICD system surveillance.

Anti-Arrhythmia Agents↗
PubMed2001

Antiarrhythmic drug use in the implantable defibrillator arm of the Antiarrhythmics Versus Implantable Defibrillators (AVID) Study.

BACKGROUND: Previous retrospective or observational series suggest that many patients with an implantable cardioverter-defibrillator (ICD) will be treated with antiarrhythmic drugs (AADs) to modify the frequency or manifestation of recurrent ventricular arrhythmias. The relative clinical benefit, however, is uncertain, and deleterious interactions can occur. The objective of this clinical investigation was to study the need for, and effects of, concomitant AAD use with the ICD in a prospectively defined cohort. METHODS: All patients randomly assigned to the ICD arm of the Antiarrhythmics Versus Implantable Defibrillators (AVID) study were followed for the addition of class I or III AADs ("crossover") after hospital discharge. Addition of AADs was strictly regulated by AVID protocol. The timing and reasons for crossover and the effects on ventricular arrhythmia recurrence were analyzed. Patients were excluded if they required AADs before hospital discharge after index arrhythmias or if they had no ventricular arrhythmia before initiation of AADs. RESULTS: After a median follow-up of 135 days, 81 (18%) of the 461 eligible patients required AADs and formed the crossover group. The primary reason for crossover was frequent ICD shocks in 64% of patients. The most common AAD selected was amiodarone (in 42%). Independent predictors of crossover were lower ejection fraction, absence of ventricular fibrillation, or presence of nonsyncopal ventricular tachycardia at presentation, prior unexplained syncope, female sex, and history of cigarette smoking. Before AAD use, the 1-year arrhythmia event rate was 90%; after AAD, the event rate was only 64% (P =.0001). The time to first event was extended from 3.9 +/- 0.7 months to 11.2 +/- 1.8 months. There were 1.4 +/- 3.7 fewer ICD therapy events (P =.005) after crossover, predominantly accounted for by reduction in shocks rather than antitachycardia pacing therapies. CONCLUSIONS: The majority of patients who receive ICDs for sustained ventricular tachycardia or ventricular fibrillation can be treated without AADs. Most commonly, AADs are added to combat frequent ICD shocks, which are successfully reduced by AAD therapy.

Aged↗
PubMed1999

Computed tomography image analyzer: segmentation applying active contour models--"snakes".

Many diagnostic and therapeutic procedures depend on medical images. In order to overcome imperfections of obtained images which are due to acquisition process and to obtain new information from available images, many techniques have been developed. In this study relatively new method of image segmentation, active contour model--"snakes" was applied in analyzing computed tomography (CT) images in patients with acute head trauma. Using this method, lesion to brain (LBR) and ventricle to brain ratio (VBR) were obtained accurately. Quantitative variable LBR, is significantly higher in patients with other pathologic CT findings and who do not survive during hospitalization. Thus, by applying segmentation "snakes" model it is possible to extract maximum information from available CT scans. These variables could be basis for medical decision making in patients with acute head trauma.

Artifacts↗
PubMed1997

A simple electrocardiographic algorithm for detecting ventricular tachycardia.

The purpose of this study was to determine whether a simple ECG algorithm could be developed for predicting susceptibility to ventricular tachyarrhythmias (VT) as defined by sustained spontaneous or inducible VT. Two different QT dispersion algorithms were determined by the difference between the longest and shortest QT interval measured in three orthogonal leads (I, aVF, V1; QTD3), and at least 11 of 12 leads (QTD12) from the 12-lead ECG. These QT dispersion algorithms were investigated (with and without the QRS duration from the 12-lead ECG) and compared to the signal-averaged ECG (SAECG) in order to determine their sensitivity and specificity for detecting VT. Only patients who underwent SAECG and were referred for programmed electrical stimulation were included in this study. A positive SAECG was defined by filtered QRS duration > 114 ms, and/or low amplitude signal duration > 38 ms, and/or root mean square voltage in the last 40 ms of < 20 microV. Sixty patients were enrolled in this study with a mean age of 63 +/- 2 years. Fifty-five percent of the patients had coronary artery disease. A simple ECG algorithm consisting of the sum of QTD3 plus the QRS duration had a sensitivity and specificity of 90% and 63%, respectively, wheras the SAECG had a sensitivity and specificity of 60% and 63%, respectively (P = 0.022). We conclude that a simple ECG algorithm is more sensitive than the SAECG for predicting VT. This algorithm combines two easily measured variables obtained from the 12-lead ECG, and can easily be performed without expensive computer equipment.

Adolescent↗
PubMed1996

Gender Differences in Patients Referred for Electrophysiology Procedures.

Gender differences are prevalent in cardiology and particularly in patients who have undergone coronary artery bypass surgery and percutaneous transluminal coronary angioplasty. The purpose of this study was to determine whether similar gender differences are present in electrophysiology. Eight-hundred seventy-three patients were identified from the ÒEP ManagerÓ database over approximately a two-year period at North Shore University Hospital. Overall, the majority of patients referred for invasiveive electrophysiology procedures were men (67 percent). A higher percentage of men had coronary disease despite the type of study/implant. There was a relatively equal distribution of men and women who underwent head-up tilt table testing (47 and 53 percent respectively). We conclude that gender differences are present in electrophysiology studies and that further studies are necessary to determine whether a bias exists in this field.

Journal Article↗
PubMed1995

Implantable cardioverter-defibrillator patch shunting effect manifestations on the body surface map.

The purpose of this study was to demonstrate the known shunting effect of implantable cardioverter-defibrillator patches using the body surface map. Using a 32-lead body surface mapping computer system (Corazonix Predictor, Oklahoma City, OK) we recorded body surface potential maps both prior to and 7 days after implantable cardioverter-defibrillator patch placement in a patient during right ventricular pacing at 60 beats/minute. This study demonstrated a marked shunting effect from the patches to the body surface during electrical depolarization as well as repolarization. In addition, patch orientation and configuration were evaluated by this method. Specifically, the waveforms were affected by the presence of insulator patches. This may be an important explanation, which may prevent appropriate transthoracic defibrillation using standard configurations. Further research is necessary to elucidate the true effect of the depolarization and repolarization waveform and defibrillator patches.

Aged↗
PubMed1995

Diagnostic approach to reflex sympathetic dystrophy after fracture: radiography or bone scintigraphy?

The aim of this paper was to compare the value of bone scintigraphy and radiography in the early diagnosis of post-fracture reflex sympathetic dystrophy (RSD). Thirty-seven adult patients with post-fracture RSD (28 in the first and nine in the second clinical stage of RSD), as well as seven patients with fracture but without RSD (control group), were investigated by radiography and bone scintigraphy. All of them were immobilized (duration of immobilization: 4-22 weeks). In 21 persons three phase bone scintigraphy was performed. The best distinction between the control group and the RSD patients was achieved by delayed bone scintigrams. The sensitivity (97%), positive predictive value (97%) and accuracy (95%) of delayed bone scintigraphy were very high compared to the values for radiography, which were 73%, 90% and 70% respectively. Bone scintigraphy also displayed higher specificity (86%) and negative predictive value (86%) than radiography (57% and 29% respectively). In the first clinical stage the difference between the accuracy of bone scintigraphy (97%) and radiography (63%) was greater than for the whole group. In the second stage of RSD the accuracy of bone scintigraphy (86%) and radiography (81%) was similar. Three-phase bone scintigraphy is not necessary for the diagnosis of post-fracture RSD: it is sufficient to perform delayed bone scintigraphy. It is concluded that bone scintigraphy is to be preferred to radiography for the early diagnosis of post-fracture RSD in the first clinical stage. In the second stage the diagnostic capabilities of bone scintigraphy and radiography are more comparable.

Adult↗
PubMed1995

Radiofrequency catheter ablation as primary therapy for supraventricular tachycardia.

BACKGROUND: Initial management of patients with supraventricular tachycardias has traditionally been with medications. More recently, radiofrequency catheter ablation offers curative therapy thus obviating the need for medications with potential side effects. The purpose of this study was to evaluate radiofrequency catheter ablation as an initial strategy to cure supraventricular tachycardias. METHODS: Radiofrequency catheter ablation was attempted as the initial therapy in 49 patients with supraventricular tachycardia, 25 with atrioventricular nodal reentrant tachycardia, 20 with atrioventricular reentrant tachycardia, two with both atrioventricular nodal reentrant tachycardia and atrioventricular reentrant tachycardia, and two with atrial tachycardia. RESULTS: Supraventricular tachycardia was rendered non-inducible in 48 of 49 (98%) patients undergoing radiofrequency catheter ablation. Thirteen of 14 patients returning for follow-up electrophysiologic study at 4.9 +/- 2.2 months had no evidence of recurrence. Three patients experienced documented recurrences of supraventricular tachycardia. One of these three patient's supraventricular tachycardia was rendered non-inducible after a final ablation session, and has had no recurrence after 24 months. The other two patients await repeat ablation. Two patients required treatment for atrial fibrillation which was documented prior to ablation. There were no complications or mortality from the procedure. CONCLUSIONS: Radiofrequency catheter ablation should be considered as first line therapy for symptomatic supraventricular tachycardia.

Adolescent↗
PubMed1994

Pseudorecurrence of paroxysmal supraventricular tachycardia after radiofrequency catheter ablation.

Over an 11-month period (November 1992 to October 1993), 32 radiofrequency catheter ablations were performed for recurrent symptomatic supraventricular tachycardia in 17 patients with atrioventricular (AV) nodal reentry, 13 with AV reentry with an accessory pathway), and 2 with both AV and AV nodal reentry. Each patient underwent both diagnostic and therapeutic electrophysiologic study with radiofrequency catheter ablation in a single session. Twelve of the 32 patients had recurrent symptoms after catheter ablation. A repeat study was performed in 9 of the 12 patients. At 7.7 +/- 0.8 months (range 4 to 11) of follow-up only one patient had had a true symptomatic recurrence. Additional sessions of ablation cured this patient. We conclude that pseudorecurrence of paroxysmal supraventricular tachycardia is a common phenomenon in patients after radiofrequency catheter ablation. Follow-up electrophysiologic study demonstrates and helps differentiate pseudo from true paroxysmal supraventricular tachycardia recurrence.

Adult↗
PubMed1990

Neurography using the intramuscular injection of ionic iodine contrast media.

Our report presents a new method of neurography. Sciatic nerve and lumbosacral plexuses in frogs have been visualized after the intramuscular injection of water and lipid soluble ionic iodine contrast media (Telebrix 300, Potassium Iodide 30% and Lipiodol Ultra Fluid). The ascendant flow of the iodine ions (anions) has been achieved by establishing the electrical potential difference between the injection site and the proximal part of the sciatic nerve and lumbosacral plexus. The application of DC current ensued immediately after the injection. Several minutes later the proximal segments of tibial and peroneal common nerves, as well as the sciatic nerve in its full length, have been visualized on X-Ray film. Lumbosacral plexuses became radioopaque after 20 plus minutes.

Animals↗
PubMed1990

[Experimental radiologic imaging of ulnar and median nerves].

This experimental study presents a new method of neurography of the ulnar and median nerves. Subcutaneous injection of water soluble iodine contrast medium (Urotrast 75%-Krka Yugoslavia) in the vicinity of the nerve immediately followed by 12V D.C. electrostimulation resulted in proximal flow of contrast medium along the epineural space versus all other structures of the nerve trunk. On X-ray films epineural space appeared as two parallel linear shadows delineating a lucent stripe which comprises all other nerve structures. By means of this method nerve X-ray images of very high quality have been accomplished for significantly shorter time than required in other procedures. The method is harmless for the patient and easily applicable.

Humans↗
PubMed1986

Unusual intra-arterial communication in the normal right coronary tree.

Among 136 patients with a history of angina pectoris who underwent selective coronary arteriography, two patients (1.4%) with a normal right coronary artery were found to have angiographically demonstrated communications between the various branches of the same coronary artery. Such findings, unaccompanied by coronary artery disease, have been hitherto unknown and suggest a congenital variation in coronary anatomy rather than a clinically significant condition. The purpose of this report is to demonstrate that the angiographic appearance of the anastomotic vessels in such cases is entirely different from that which obtains in cases of obstructive coronary artery disease. The author notes the rarity of angiographic visualization of homocoronary communications in normal right coronary arteries and emphasizes the necessity of distinguishing these from the homocoronary collaterals found in atherosclerotic coronary artery disease.

Adult↗