[Evolution of enzymuria in the course of acute renal insufficiency caused by non-steroidal anti-inflammatory agents].
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Acetylglucosaminidase↗
Biomedical subjects
B Gravagna
Publications and source records attributed to B Gravagna.
[Evaluation of enzymuria as a tracer in nephrotoxicity: results of a multicenter study].
Urinary excretion of three enzymes of different subcellular location in kidney tissue, alanine aminopeptidase (AAP), gammaglutamyltransferase (GGT), N acetyl-beta-D glucosaminidase (NAG), was carried out in 79 healthy adults and 108 healthy children and in 69 adults with various therapies: antibiotics (32 cases), non steroidal anti-inflammatory drugs (NSAIDs) (22 cases), cisplatinum (12 cases) and cyclosporine (3 cases). A circadian rhythm has been shown in children. In patients treated with antibiotics, the importance and duration of the increased enzymes urinary excretion were variable but the excretion of AAP was always higher than that of GGT and NAG. Short term therapies by NSAIDs were without influence on enzymuria but long term therapies produced a moderate increase of NAG excretion. Enzymuria increased immediately after cisplatinum administration and decreased after each daily dose, except in patients with previously high creatininemia. Cyclosporine induced a slight increase in AAP and NAG excretion. Enzymuria, thus, increased early reflecting a toxic effect of the drug at the cellular level whereas creatininemia increase, marker of renal fonctionnal insufficiency, occurs only occasionally and lately.
Acetylglucosaminidase↗
[Enzymuria].
Study of enzymuria rises more and more interest in human pathology as a diagnosis parameter of renal diseases or as an index of nephrotoxicity. In this two fields, the literature demonstrated the interest of enzymes of the brush border of proximal tubuli (alanine amino peptidase, gamma glutamyl transpeptidase, alkaline phosphatase) and of lysosomal enzymes (beta glucuronidase and N acetyl beta D glucosaminidase). The authors analyse the problems limiting the present use of these methods: incomplete knowledge of enzyme of the different parts of the renal tissue and of the mechanisms of enzymuria (choice of enzymes and time periods for sampling); analytical problems referring to the study of enzymes in a complex medium (treatment and storage of samples, choice of adapted methods for activity measurement); at last the way of expression the results is still to be defined.
Clinical Enzyme Tests↗