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Biomedical subjects

B Griffel

Publications and source records attributed to B Griffel.

At least 37 records · Page 2Linked to original sources
PubMed1984

A model for adhesion formation by thermal injury in the abdominal cavity of the mouse.

An experimental model for inducing peritoneal adhesions in mice is described. Measurable thermal trauma can be inflicted by the application of a heated metal object, for a given lapse of time, to the surface of a section of mouse intestine. Parameters of temperature, area and application time were so manipulated as to obtain adhesions in only 70-75% of treated mice. It is maintained that this model can enable better evaluation of various prophylactic means and also the detection of exacerbating agents.

Animals↗
PubMed1984

Cellular events in adhesion formation due to thermal trauma.

Consequent to thermal traumatization of the intestinal wall of the mouse, histopathological events ensue which lead to peritoneal adhesion formation. In the first 48 h, the main pathological findings are of a necrotic and inflammatory nature, but subsequently fibroplasia is the main feature, as evidenced by the appearance of spindle-shaped cells followed by fibroblasts. Factors essential for and contributing to the formation of adhesions are described.

Animals↗
PubMed1983

Latent childhood thyroid carcinoma in diffuse lymphocytic thyroiditis.

Diffuse thyroid enlargement in a child is a rare presenting symptom of thyroid carcinoma. A papillary carcinoma may be hidden in a diffuse lymphocytic thyroiditis and should be carefully searched for during surgery. Furthermore, the finding, in frozen sections, of psammoma bodies in a lymphocytic thyroiditis should raise the suspicion of an occult malignant neoplasm. A case illustrating these diagnostic difficulties in a 5-year-old child is presented.

Carcinoma, Papillary↗
PubMed1983

[Clinical and histological study of 25 cases of hydronephrosis caused by primary stenosis of the pyeloureteral junction].

The authors report 25 cases of primary stenosis of the pyelo-ureteric junction (PUJ) in terms of their clinical and histological features. Based on a semi-quantitative study of the histological modifications, the authors attempt to determine whether these modifications are primary and therefore responsible for the stenosis of the PUJ or wether, on the contrary, these changes are secondary to the stenosis. After studying 25 children and adults, it appears that these histological signs are primary and responsible for the malformation: rarefaction of the muscle layers (24 cases out of 25), fibrosis of the sub-mucosa or intermuscular layer in every case, presence of valvular mucosal folds in every case but one.

Adolescent↗
PubMed1982

Comparative histology of the mouse bladder following initial infection and re-infection with Escherichia coli.

The present study continues our investigation of the bladder antimicrobial mechanisms following bacterial infection. Since the process of spontaneous clearance of bacteria (E. coli) from the mouse bladder is greatly accelerated upon re-infection, a histopathological comparison was made of initially infected (II) versus re-infected (RI) mice. It was reconfirmed that the spontaneous clearance upon re-infection is indeed much faster than after the initial infection. There were morphological differences between these two courses of infection, as well as in the localization and composition of the inflammatory response. Thus cellular infiltration was more evident in the epithelium of the II mice, whereas the RI animals displayed increased cellular exudation in the lamina propria. It was also found that the dominant cell in the II mouse is the granulocyte and in the RI mouse--lymphocytes, macrophages and plasma cells. This last finding is suggestive of a local immunological process. The overall results are consistent with the notion that a local immune response develops in the infected bladder and participates in the enhanced clearance in RI animals.

Animals↗
PubMed1981

Angioimmunoblastic lymphadenopathy with paraproteinemia: a T- and B-cell disorder.

A case is reported of angioimmunoblastic lymphadenopathy (AILD), in which a IgM Kappa monoclonal gammopathy developed. On the first admission the immunoblasts were shown to be T cells by surface-marker studies. Although the number of circulating T cells was normal, their functional capacities were markedly reduced. The patient was followed for two months at the end of which she died with hematologic features of immunoblastic plasma cell leukemia.

Agammaglobulinemia↗
PubMed1981

Renal involvement in Gaucher's disease.

A patient with chronic Gaucher's disease is described who developed glomerulopathy 24 years after splenectomy terminating in renal failure. The pathological changes of this very rare complication of Gaucher's disease are described. The few similar cases reported in the literature are reviewed and the possible pathogenetic pathways discussed.

Female↗
PubMed1980

Spontaneous bacterial clearance in experimental urinary tract infections in mice: cellular aspects of the process.

The morphological aspects of Proteus mirabilis clearance from the urinary tract of experimentally infected mice were investigated. For this purpose, two groups of mice were compared: a group infected with the bacterium and a group that had just recovered from the infection. Differences between the two groups were found in extent of bladder and kidney inflammation, depth of infiltration into the bladder wall, and in the increment of bladder volume. There was no clear-cut difference between the two groups in number of lymphocytes and monocytes, but the number of granulocytes was significantly lower in the bladder and kidneys of the recently healed animals. Likewise, the plasma cells were fewer in healed animals than in infected ones, the difference being statistically significant for bladders and on the verge of significance for kidneys.

Animals↗
PubMed1980

Minimal-change nephropathy and malignant thymoma.

A 56-year-old man had fever, precordial pain, and a mediastinal mass. The mass disappeared two months later and the patient remained asymptomatic for 2 1/2 years. At that time a full-blown nephrotic syndrome developed, with minimal-change glomerulopathy. The chest x-ray film showed the reappearance of a giant mediastinal mass. On biopsy of the mass, malignant thymoma was diagnosed. Association between minimal-change disease and Hodgkin's disease is well known, while the association with malignant thymoma has not been previously reported. The relationship between malignant thymoma and minimal-change disease is discussed, and a possible pathogenic mechanism involving cell-mediated immunity is proposed.

Humans↗
PubMed1980

Papillary cystadenofibroma of the endometrium.

Six cases of papillary cystadenofibroma of the endometrium were found in he medical literature. A seventh case of this kind of tumor is now described clinico-pathologically and the literature pertinent to this particular type of tumor reviewed.

Adenofibroma↗