Biomedical subjects

B Guschlbauer

Publications and source records attributed to B Guschlbauer.

40 records · Page 3Linked to original sources

PubMed1984

Improvement of ataxia in alcoholic cerebellar atrophy through alcohol abstinence.

Postural instability was measured and short, medium and long latency EMG responses to angular displacement of the ankle were recorded from leg muscles in a group of 17 alcoholics who presented with clinical signs of cerebellar atrophy of the anterior lobe. Recordings were performed twice (average interval 18.5 months) to determine the effects of continued drinking versus abstinence on the signs of the cerebellar damage. Patients who were abstinent (n = 11) exhibited a significant, sometimes dramatic decrease of body sway whereas patients who continued drinking (n = 6) showed increased body sway when the eyes were closed. Short and medium latency EMG responses were unaltered in both groups of patients. The integral of the long latency response of the antagonist tended to increase with continued abuse and to decrease in abstinent patients.

Adult↗

PubMed1984

The significance of delayed long-loop responses to ankle displacement for the diagnosis of multiple sclerosis.

The present study compares the results of sensory evoked potentials after stimulation of the tibial nerve with measurements of short (M1), medium (M2) and long-loop latency (M3) responses of leg muscles in 42 patients suffering from multiple sclerosis. EMG responses were elicited by a movable platform which was tilted in pitch toe-up around the subject's ankle joint. The short latency response of the triceps surae muscle was nearly always normal in latency. The M2 response was lacking in about 30% of the patients and 10% of normals. The long latency response (M3) in the antagonistic anterior tibial muscle was significantly delayed (beyond 162 msec = AM + 2.5 S) in 69% of the patients. The delayed M3 response was found to indicate demyelination as reliably as the delayed somatosensory evoked potential (66% of the patients). The frequency of coincident results in the entire group was 86%. Additional information is gained in cases where SEPs are normal, but M3 is delayed (7%). Furthermore, patients lacking P40 of the SEP still exhibit M3 responses, the latency of which may be measured (24%). The results favour the assumption that M3 is mediated by a supraspinal pathway.

Ankle↗

PubMed1984

Characteristic alterations of long-loop "reflexes" in patients with Friedreich's disease and late atrophy of the cerebellar anterior lobe.

Sudden tilting of a platform around the axis of the human ankle joint causes a regular pattern of short and medium latency EMG responses in the stretched triceps surae muscle and a long latency response in its antagonist, the anterior tibial muscle. This paper reports alterations of these EMG responses in 41 patients with cerebellar lesions. Patients with anterior lobe atrophy exhibited normal latencies of all EMG responses, but an increase in duration and amplitude of the long latency response. This may at least partially explain the 3 Hz postural tremor, which can be evoked in these patients through a toe-up tilt of the platform. Patients with lesions restricted to the vestibulocerebellum and to the cerebellar hemispheres exhibited normal latencies of all EMG responses. The most specific finding in all of the patients suffering from Friedreich's ataxia (affecting spinal afferents) was the massive delay of the stabilising response of the anterior tibial muscle. The fact that the patients with lesions restricted to the cerebellum invariably exhibited normal latencies of postural "reflexes" indicates that the exact "timing" of these responses is independent of the cerebellum. The duration and amplitude of the long latency response of the antagonist, however, seems to be controlled by the cerebellum.

Afferent Pathways↗

PubMed1981

Lectin-induced lymphocyte stimulation in pigs--a kinetic study of NORs.

Early reactions of rRNA-cistrons in lectin-stimulated PBL cultures of domestic pigs are shown. Interphases showing 3 or more clusters of stained areas were attributed mainly to cells after first division. Clear differences are shown between PHA- and ConA-induced NOR-expression patterns compared to the patterns in PW-stimulated cultures.

Animals↗