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Biomedical subjects

B Guyot

Publications and source records attributed to B Guyot.

24 records · Page 2Linked to original sources
PubMed1993

Endogenous digoxin-like immunoreactivity during pregnancy and at birth.

1. We have measured endogenous digoxin-like immunoreactivity (EDLI), in mothers and infants, during normal/pathological pregnancies and at birth. 2. During pregnancy, EDLI was measured in 38 maternal-fetal pairs. At the time of fetal sampling, maternal age was 29 (s.d. 6) years and gestational age was 28 (s.d. 6) weeks. EDLI was present in 13 (34%) mothers and in 27 (71%) fetuses. There was no correlation between maternal and fetal concentrations or between maternal or fetal concentrations and gestational age. 3. EDLI was measured at birth in blood samples from 45 maternal-cord pairs. Maternal age was 29 (s.d. 5) years and gestational age was 39 (s.d. 2) weeks. EDLI was present in 11 (22%) maternal and in 44 (98%) cord samples. The concentrations were significantly higher in cord than in fetal or maternal samples (P < 0.001 in both cases). 4. High cord EDLI concentrations suggest acute synthesis during delivery. Thus, the placental transfer of digoxin calculated from maternal and cord digoxin concentrations at birth may be overestimated.

Adult↗
PubMed1992

Relationship between umbilical and fetal cerebral blood flow velocity waveforms and umbilical venous blood gases.

Nineteen women (mean +/- SD: 28 +/- 5 years) with small fetuses relative to gestational age (mean +/- SD: 32 +/- 2.2 weeks of gestation) were referred to our unit for cordocentesis for the determination of fetal karyotyping. Four of these 19 patients had small-for-gestational-age ultrasound-derived measurements under the third centile for gestational age. Fetal blood gases were measured in the umbilical vein. Umbilical artery and fetal internal carotid artery Doppler examinations were performed 15 min before cordocentesis. The results showed a progressive and proportional increase in umbilical artery resistance index with hypoxia (p < 0.001), hypercapnia (p < 0.025) and acidosis (p < 0.005). Moreover, the results showed a progressive and proportional decrease in fetal internal carotid artery resistance index with hypoxia (p < 0.01), hypercapnia (p < 0.01) and acidosis (p < 0.025). Fetal blood gases are therefore related to umbilical circulatory function and cerebral vasodilatation, suggesting fetal vascular redistribution.

Journal Article↗
PubMed1988

Prenatal diagnosis with biotinylated chromosome specific probes.

We have used a Y-chromosome specific DNA probe in a controlled study to determine the presence of Y-chromosome material and to detect numerical abnormalities in uncultured amniotic fluid cells by fluorescent hybridization. Using this non-radioactive method, we correctly predicted fetal sex within 48 h in all but 3 of 54 cases and identified an XYY syndrome. The technique was previously tested with no false-positive or false-negative results on cultured interphase or metaphase nuclei of fetal fibroblasts and adult T-lymphocytes. Fluorescent in situ hybridization was applied to long-term fixed cytogenetic preparations up to 44 months old and was shown to be reliable.

Amniocentesis↗
PubMedDate not supplied

[Hysteroscopic cure under ultrasonic control of complex and/or recurrent uterine synechiae].

Hysteroscopy now plays a major role in the rapidly changing therapeutic approach to the diagnosis and treatment of uterine synechiae. The fibrous nature of the lesion and its precise localization can be determined. Operative hysteroscopy has greatly benefited from technological progress in optic fibers and instrumentation. It is now possible to control the endocavitary operation with a video-endoscope. In this report, we present preliminary results obtained in 11 patients who underwent echo-controlled hysteroscopic surgical cure of complex and/or recurrent uterine synechiae. The intra-operative echographic control was validated in the operating theatre radiographically. Intra-operative echography allowed hysteroscopic lysis of intrauterine adhesions at a controlled and equivalent distance from the uterine walls. It is thus possible to better treat the uterine cornua since the operator is informed when to limit progression to avoid massive fluid infusion into the abdominal cavity and perforation of the uterus. With this technique we obtained 8 normal cavities with bilateral tube permeability. Normal cycles were achieved in 10 patients. The effect of this newly developed technique on improving fertility cannot yet be established.

Adult↗
PubMedDate not supplied

[The infected cervix].

Cervico-vaginal infections while easily identified, can in certain cases, in fact quite frequently, be under-diagnosed because of the absence of visible symptoms. Colposcopic access to the cervix or vagina can aid diagnosis of cervico-vaginal infections but may not be adequate to pinpoint the agent of the infection except in certain cases such as Herpes and HPV. On the other hand, cervical-vaginal infections can impede a colposcopic interpretation such as identifying the squamo-columnar junction or the location of a directed biopsy. Cervical infections can equally cause unexpected complications (notably Haemorrhagie or pelvic infections) during or after surgical Colposcopic procedures.

Acute Disease↗