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Biomedical subjects

B H Krayenbühl

Publications and source records attributed to B H Krayenbühl.

5 recordsLinked to original sources
PubMed2000

Silicone granuloma.

Since silicone has rapidly become one of the most commonly used prosthetic materials in the last 30 years in modern medicine, we have consequently been witnessing more silicone-related disease. Especially after silicone breast implantation, defects in the breast implant have led to serious complications, whereas complications of silicone prosthesis implantation in other body parts are less frequent. Here we present an unusual clinical presentation of a silicone granuloma in a patient with a 27-year history of a wide excision of a melanoma of the right lower extremity and subsequent soft-tissue reconstruction using a silicone device.

Electron Probe Microanalysis↗
PubMed2000

Bullosis diabeticorum in a newly discovered type 2 diabetes mellitus.

Bullosis diabeticorum (BD), although a rare manifestation, is characteristic of diabetes mellitus. The exact origin of BD is unknown. We report another case of a 54-year-old man who developed a blistering lesion on his left leg. Histopathological examination revealed a microangiopathy with hyalinosis of the blood vessel walls.

Diabetes Mellitus, Type 2↗
PubMed1999

Allergic and irritant contact dermatitis to calcipotriol.

Calcipotriol (Daivonex R; Leo Pharmaceuticals, Zurich, Switzerland) may cause irritation of the skin, whereas allergic reactions are less common. In the present study we describe two patients with different types of reaction patterns, one presenting as an allergic, the other as an irritant contact dermatitis. Irritative skin reactions were observed only at higher testings doses, in contrast to the allergic type of reaction, which occurred at a lower testing dose. The present observation suggests, that a batch of different testing doses, including lower testing doses may help to differentiate between an allergic type of contact dermatitis and an irritant type of reaction after treatment with calcipotriol.

Administration, Topical↗
PubMed1996

Puncture-mediated gene transfer to the skin.

Simple and efficient gene transfer to the skin would facilitate many local and systemic gene therapy applications. Here we report a novel approach that allows installation and expression of plasmid DNA without a particulate carrier into the skin for the purposes of gene therapy. A device with a constantly high-frequency oscillating bundle of fine metal needles allows puncturing of the skin and leads to DNA transfer to skin-associated cells and expression of reporter genes in mice. Furthermore, puncture-mediated instillation of an expression vector coding for a single T cell epitope induces specific cellular immune responses. If this approach could be optimized, puncture-mediated gene transfer might be useful for the treatment of large body areas with plasmid DNA for the purpose of somatic gene therapy.

Amino Acid Sequence↗