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Biomedical subjects

B H McClellan

Publications and source records attributed to B H McClellan.

8 recordsLinked to original sources
PubMed1997

National Cooperative Growth Study substudy VIII: a new look at the natural history of short stature.

National Cooperative Growth Study (NCGS) substudy VIII was designed to determine the characteristics of children who are referred to pediatric endocrinologists for evaluation of short stature but are not treated with growth hormone (GH). No specific course of treatment is required to enter the study. Data on the subjects' characteristics at enrollment, the diagnostic procedures used by the investigators, and the occurrences of various medical conditions and intercurrent illnesses will be collected prospectively and will be compared with the corresponding data on children in the NCGS who are treated with GH.

Body Height↗
PubMed1990

Growth hormone treatment in the United States: demographic and diagnostic features of 2331 children.

Demographic, diagnostic, and baseline clinical data were collected for a large cohort (N = 2331) of children who started treatment with biosynthetic human growth hormone (GH) between October 1985 and October 1987. Eighty-one percent met classic criteria for GH deficiency and were classified as having idiopathic GH deficiency (59%), organic GH deficiency (18%), or septo-optic dysplasia (4%). The remaining 19.8% had short stature of varied causes. Height standard deviation score at diagnosis, maximum GH response to stimulation, and heights of parents were examined according to gender, race, age at diagnosis, and previous treatment history. The predominance of boys in all subgroups except septooptic dysplasia, and the observation that girls with idiopathic GH deficiency were comparatively shorter than boys at diagnosis, suggest ascertainment bias. Black children with idiopathic GH deficiency were shorter than white children at diagnosis, and their low overall representation (6.0%) compared with their percentage in the at-risk population (12.9%) also suggest ascertainment bias among races. These data provide a profile of GH deficiency as it is currently defined and expose possible inherent biases in the diagnostic process. Now that GH supply is no longer limited, criteria for its use should be formulated to avoid apparent underascertainment or late diagnosis of GH deficiency in girls and black children.

Adolescent↗
PubMed1975

Immunoglobulins in the human cornea.

We examined 20 corneas of ten subjects to determine the amounts and distribution of immunoglobulins and albumin. Immunoglobulins IgG and IgA were found in all corneas, were at the same level centrally and peripherally, and were at one-half and one-fifth the serum levels respectively. The amount of cornea IgG correlated with serum IgG, but not with IgA. Immunoglobulin IgM was present in five of the ten sets of eyes. No IgM was detected in the central buttons of four of the five sets where IgM occurred in the corneal periphery. Albumin was present in all corneas, but less centrally than peripherally. The cornea contains high levels of antibody proteins.

Adult↗