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Biomedical subjects

B H Meyer

Publications and source records attributed to B H Meyer.

48 records · Page 3Linked to original sources
PubMed1982

The effect of fructose on blood alcohol levels in man.

Ten volunteers participated in a trial to determine the effect of fructose on blood alcohol levels when given immediately after the administration of ethyl alcohol. The subjects were randomly assigned to receive two 'treatments', viz.: (i) alcohol followed by placebo; and (ii) alcohol followed by fructose. Each volunteer participated in both phases of the study, receiving both forms of treatment with a 7-day 'wash-out' period between the two. The maximal alcohol concentration attained was significantly lower in subjects who had taken fructose immediately after the alcohol. The area under the alcohol concentration time-curve seen after the subjects had taken alcohol plus placebo was significantly greater than that seen after they had taken alcohol plus fructose. A comparison of the blood alcohol levels attained with the two treatments at each sampling time revealed significantly higher concentrations from 45 minutes onwards when alcohol plus placebo was taken. The time taken for the attainment of maximal blood alcohol concentrations was not affected by the addition of fructose.

Adult↗
PubMed1982

Potassium balance in piretanide and digoxin treatment.

Piretanide, a new potent diuretic, was given to 18 healthy male subjects to determine its effect on serum, total body (TBK), and red cell potassium (RCP). TBK and RCP were measured before treatment to establish baseline values, after which all subjects received 6 mg piretanide a day for 14 days. After this period subjects were divided into two groups; group 1 received 6 mg/day piretanide for 14 more days and group 2 received the same dose of piretanide with 0.5 mg digoxin daily during the remaining 14 days. All treatments were terminated after 28 days, but subjects remained under observation for another 14 days. Serum potassium, TBK, and RCP were measured weekly during the 42-day period. Piretanide in a dose of 6 mg daily for a period of 6 wk did not induce a fall in serum potassium, TBK, or RCP. The addition of digoxin for 2 wk after piretanide alone for 2 wk did not decrease serum potassium and TBK, but RCP fell under the influence of piretanide with digoxin.

Adult↗
PubMed1981

The effect of penbutolol on glomerular filtration.

Penbutolol, a new beta-adrenoceptor blocker, was found to increase the glomerular filtration rate (GFR) significantly (16%) relative to placebo when administered orally in a dose of 40 mg daily for 7 consecutive days to healthy males. Measurements were performed after the seventh dose. In contrast, a single acute intravenous dose of penbutolol 4 mg did not influence the GFR, which was determined by means of a gamma counter after intravenous injection of technetium-99m diethylenetriaminepenta-acetic acid. Since penbutolol possesses moderate beta-adrenomimetic activity, it is postulated that the observed increase in the GFR after oral penbutolol could be due to increased cardiac output at rest.

Administration, Oral↗
PubMed1981

Penbutolol and furosemide in a fixed-dose combination-bio-equivalence of two formulations.

Twelve healthy male volunteers participated in an open cross-over study designed to test whether two fixed-dose combination formulations of penbutolol (40 mg) and furosemide (20 mg), an ordinary and a film-coated tablet, are bio-equivalent. Penbutolol capsules (40 mg) and 20 mg furosemide tablets (Lasix; Hoechst) served as reference formulations. The maximum concentration of furosemide was significantly depressed in the case of fixed-dose combinations, reflecting a possible pharmacokinetic interaction between penbutolol and furosemide. However, the area under the concentration versus time curve for furosemide and its cumulative urinary excretion and diuretic effect were not influenced by penbutolol. On the basis of plasma concentration versus time data and urinary parameters, the two fixed-dose formulations are bio-equivalent.

Adult↗
PubMed1980

Etomidate as anaesthetic induction agent in open-heart surgery.

Etomidate (Hypnomidate; Ethnor (Janssen)) in propylene glycol was used for induction of anaesthesia in 25 patients requiring cardiac surgery, and the effects on pulse and blood pressure were measured. It is concluded that etomidate is a suitable induction agent for open-heart surgery.

Adolescent↗
PubMed1979

[Trancutaneous measurement of arterial oxygen tension during anesthesia].

The transcutaneous oxygen tension was measured in 29 anaesthetized patients by means of a TCM1 TC Oxygen Monitor (radiometer). The correlation coefficient between these transcutaneously determined values and the true PaO2 values was 0,81 as compared with 0,93 in a previous trial in which a Servomed Oxymonitor (Hellige) was used. The effect of diathermy on the TCM1 TC Oxygen Monitor was much less than that on the Hellige apparatus.

Anesthesia, General↗
PubMed1979

[Perforation of the heart during implantation of a transvenous pacemaker. A report on two cases].

Perforation of the right ventricular wall occurred in 2 patients during implantation of a transvenous temporary pacemaker. Although neither of the patients showed any signs of symptoms of pericardial tamponade, blood was found in the pericardial sac at thoracotomy, by means of which epicardial pacemakers were inserted. The possibility of tamponade should therefore be kept in mind when anaesthetizing patients who received a temporary transvenous pacemaker.

Aged↗
PubMed1975

[Free-flow electrophoresis. I. Theoretical and experimental investigations of the influence of mechanical and electrokinetic variables on the efficiency of the method].

In the present paper, various types of band-broadening effects in free-flow electrophoresis were investigated. They resulted from the velocity profiles of the liquid curtain and electroosmosis, temperature gradient, thermal diffusion and sample inlet geometry. An analytical free-flow electrophoresis apparatus permitted easy observation of these parameters. The experiments showed that the influence of the temperature gradient was negligible, whereas the effect of the velocity profiles on band broadening was higher than theoretically expected. In preparative work this is of utmost importance, since overlap of bands is not desirable. In this case, the zeta potential of the walls can be adjusted to that of the material to be separated, resulting in a considerable reduction of band broadening. Various approaches are indicated. Further attention was given to the influence of the relaxation effect on the separation. Conditions are shown where particles are separated either according to their surface charge density or to their size. The practical relevance of the results is discussed.

Electrophoresis↗