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B H Shapiro

Publications and source records attributed to B H Shapiro.

80 records · Page 5Linked to original sources
PubMed1975

Aging and ovarian delta5-3beta-hydroxysteroid dehyrogenase in rats.

Ovarian delta5-3beta-hydroxysteroid dehydrogenase activiety and protein content were determined in long-evans rate 1-24 mo of age. Activity of the enzyme per miligram of protein was maximal between 2 and gram of protein was maximal between 2 and 4 mo of age and declined theragter. Ovarian enzyme activity of the 24-mo old rat was significantly less than that of the prepubertal animal. Total ovarian enzyme acitivity was maximal in 4-mo old rats. A decline in ovarian protein was noted between 4 and 24 mo of age.

Aging↗
PubMedDate not supplied

Normal levels of hepatic drug-metabolizing enzymes in neonatally induced, growth hormone-deficient adult male and female rats.

The effects of chronic growth hormone deficiency on the growth hormone-dependent, sexually dimorphic hepatic drug-metabolizing enzymes were studied in adult rats of both sexes. Neonatal administration of monosodium L-glutamate produced the expected syndrome characterized by stunted growth, obesity, prolonged vaginal estrus, and an inhibition in the growth of the pituitaries, adrenals, gonads, sexual accessory organs, and kidneys. Associated with these abnormalities was a 90% reduction in the concentration of serum growth hormone in male and female rats. In contrast, the activities of hepatic aniline hydroxylase, total cytochrome P-450, and the Michaelis constants and maximal velocities for hexobarbital hydroxylase and UDP-glucuronosyltransferase were unaffected by the profound deficiency in growth hormone.

Animals↗