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Biomedical subjects

B Habibi

Publications and source records attributed to B Habibi.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Transmission of AIDS virus by transfusion and blood products. Risks and preventive strategies].

This article reviews some of the epidemiologic aspects of transmission of LAV through transfusion of blood and blood products in the light of data available until late December 1985 in France, Europe and the United States. As of December 1985, blood transfusion has been considered the etiologic factor in 2.58% of the 15,172 cases of AIDS reported in the USA and in 5.6% of 1,573 cases of AIDS registered in Europe. Whole blood, cellular blood components and plasma derivatives except Albumin and immunoglobulins have been incriminated in 1.75 to 2.22 of the above percentages. Hemophiliacs under long term therapy by factor VIII and factor IX concentrates (0.83 to 3.36 of the above percentages) represent a highly exposed group when one considers the small proportion of these individuals in the general population (1/10,000 inhabitants). Three preventive measures have been officially implemented in the French transfusion network: self refrainment and deferral of prospective donors belonging to risk factor groups, systematic screening of donated blood for the presence of anti-LAV antibodies and elimination of seropositive units, heat treatment of coagulation factor concentrates to achieve viral inactivation. Information and medical follow up of LAV-contaminated donors thus identified and of their partners represent an important issue among the current public health problems.

Acquired Immunodeficiency Syndrome↗
PubMed1985

[Human fibronectin in the treatment of septic states. Tolerance and course of plasma levels].

A purified freeze-dried fibronectin concentrate prepared by the Centre National de Transfusion Sanguine from blood donors' plasma pools was tested for safety and effects on recipients' plasma fibronectin levels. The product was administered on 17 occasions to 10 patients with severe sepsis, either as bolus intravenous injection (group B) or as bolus injection of one-half of the dose followed by continuous infusion of the remaining half-dose over a 6-hour period (group B + P). The drug was well tolerated both clinically and biochemically. Following a 1 mg/kg dose of fibronectin, the maximum increase in mean plasma fibronectin levels was 17 +/- 5 mg/l in group B patients and 20 +/- 5 mg/l in group B + P patients. Mean times to peak were 188 +/- 53 min and 282 +/- 106 min respectively in the two groups. A cooperative randomized double-blind trial is currently in progress to evaluate the clinical effectiveness of the product.

Adult↗
PubMed1985

Drug induced red blood cell autoantibodies co-developed with drug specific antibodies causing haemolytic anaemias.

Four individuals with anti-glafenine, anti-latamoxef and anti-teniposide antibodies were found to have an associated red blood cell autoantibody. The two components could be separated by selective absorption and showed distinct time course patterns. In three patients a well-defined blood group antigen was recognized as the receptor for both auto- and drug specific antibodies. Similarities between this type of immune response to drugs and the well-known hapten and carrier specificities developed in animals immunized by hapten-carrier conjugates are discussed.

Aged↗
PubMed1979

Protease inactivation of the red cell antigen Xga.

The study of the agglutinability of Xg(a + ) cells by several examples of anti-Xga and absorption-elution tests showed that the red blood cell antigen Xga is destroyed by proteases commonly used in blood group serology but not by neuraminidase.

Blood Group Antigens↗
PubMed1978

[Auto-immune haemolytic anaemia and mediastinal dysembryoma in a 6-year-old child (author's transl)].

In a six-year-old girl, suffering from an auto-immune haemolytic anaemia, routine radiological examination revealed the presence of a mediastinal tumour which was removed surgically and proved to be a multiple tissue polycystic dysembryoma. Haemolysis and signs of anti-erythrocyte auto-immunisation disappeared after the operation and total and stable cure obtained with a follow-up of 15 months. The target antigen of the anti-erythrocyte autoantibody could not be found within the tumour. However, the latter contained lymphoid tissue and a considerable quantity of antibody. Although indirect, these findings offer arguments in favour of the secretion of autoantibodies by the dysembryoma.

Anemia, Hemolytic, Autoimmune↗
PubMed1978

The antigen Duclos. A new high frequency red cell antigen related to Rh and U.

An antibody is described which defines a new high frequency red cell antigen, Duclos, whose expression seems to require the presence of both U and Rh fundamental antigens. Apart from the antibody maker's own red cells the only nonreactive samples were from Rhnull U impaired individuals, one example of which was shown however to yield very slight amounts of antibody through absorption-elution tests. Rhmod U weak cells gave very depressed and Rhnull U positive or Rh common U negative cells moderately depressed reactions. The proposita's red cells had an apparently normal Rh-LW condition but their U antigen was significantly decreased. No further Duclos negative individual was found by screening 8,500 blood donors in the Paris area.

Aged↗
PubMed1978

Fine-structural changes in the nucleus of primordial oocytes in immature hamsters.

This study reports observations on fine-structural changes in the nucleus of the oocyte in hamsters during the establishment of the primordial (unilaminar) follicle at 7 to 12 days after birth. Following pachytene, the nuclei at early diplotene contain simple chromosomal cores surrounding by a sheath of fibrillo-granular material symmetrically disposed in the form of lateral projections and loops. From 9 days onwards increasing numbers of the oocytes show nuclei lacking such chromosomal threads: instead, they contain randomly disposed, condensed fibrillar clumps with associated dense knots of material, and prominent aggregations of 25--30-nm granules. This second nuclear form is assumed by all oocytes examined at 11 and 12 days and appears to be the definitive diplotene phase. These changes in the appearance of the nuclear chromatin are discussed in the light of those found in oocytes of other species, and it is concluded that the hamster diplotene phase consists of a transitory 'compace' or uniform lampbrush stage, followed by a definitive dictyate condition like that in the rat, but with markedly differential condensation or extreme diffusion of lateral loops. This conclusion is examined in relation to findings which report a marked increase in the sensitivity of hamster oocytes to X-radiation at the time that the observed changes in nuclear configuration are taking place. The combined observations support the hypothesis that the dictyate stage in rodent oocytes represents a modified diplotene phase in which the high degree of spatial diffusion of components of chromosomes of the lampbrush type results in a reduced capacity for repair following exposure to ionizing radiations.

Animals↗
PubMed1977

[Antigen Fyx: quantitative study of subjects FybFyx, FyaFyx and FyxFyx from two new families].

Two new families are described in which multiple examples of antigen Fyx are found in homo-and heterozygous states. The expression of the antigen is evaluated by conventional methods (agglutination scoring) and HD50 assays using a polybren-citrate autoanalyzer technique. Individuals from both families are tested in parallel with those from the family of the first known examples of homozygous FyxFyx described by Cedergren and Giles [2], and with 59 known FyaFyb and FybFyb controls. No consanguinity is found in the two families reported. Quantitative study of anti-Fyb absorption by red cells reveals that the expression of Fyb in individuals considered to be FybFyx is weaker than in FybFyb and even FyaFyb controls. HD50 assay data obtained in the control donors population seem to indicate that, in contrast to the admitted opinion, intermediate degrees of antigenic strength do exist between "normal" Fyb and Fyx the definition of which, based on quantitative criteria, remains unprecise. Using a new potent anti-Fy3 (AR), the expression of Fy3 displayed a slight and variable decrease in FyxFyx samples investigated.

Blood Group Antigens↗