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Biomedical subjects

B Hammer

Publications and source records attributed to B Hammer.

At least 19 recordsLinked to original sources

[Headache, fever and upper abdominal colic].

A nine year old boy who had received Ceftriaxone for one week because of suspected bacterial meningoencephalitis developed colicky abdominal pain in the right upper quadrant two days after termination of Ceftriaxone treatment. Stones in the gallbladder were identified as cause of the abdominal symptoms. Ceftriaxone has been reported to result in so-called pseudo-lithiasis of the gallbladder in approximatively 45% of treated patients, 19% of which developed clinical symptoms. Generally, the gallstones dissolve spontaneously when Ceftriaxone treatment was of short duration.

Ceftriaxone

A look at ear canal changes with jaw motion.

Two procedures were used with one subject to examine changes in the ear canal with jaw motion. Silicone ear impressions were examined to measure the effect of jaw position. Magnetic resonance imaging was used to define the three-dimensional structure of the canal and visualize key underlying tissue. Results showed that inexpensive impressions can detail changes in the cartilaginous region of the canal. Approximately a 25% change in this subject's ear canal with different jaw positions was observed in the anterior/posterior plane with essentially no change in the superior/inferior plane. This is likely related to asymmetric stress from action of the mandibular condyle on neighboring cartilaginous tissue. Solutions to jaw motion-induced feedback problems are suggested.

Ear Canal

[Post-traumatic meningioma (author's transl)].

Report on a post-traumatic meningioma diagnosed 37 years after the trauma. Reference to relevant cases and the value of computed tomography for medico-legal opinion in post-traumatic sequelae.

Aged

[Computer tomographic diagnosis of a mega-dolicho basilar artery (author's transl)].

Four mega-dolicho basilar arteries are described, which were found by computer tomography and confirmed by angiography. Two patients showed additional abnormalities or anomalies of other vessels. The computer tomographic features are described. The elongated vessels can produce so-called normal pressure hydrocephalus by impressing the floor of the third ventricle, although the hydrocephalus cannot be confirmed by computer tomographic cisternography.

Aged

[Inspection of 1 to 5-year-old amalgam, composite, and cast gold fillings].

On 103 randomly chosen patients composite-, amalgam-, and cast gold fillings were checked and examined after various criteria. Also, the gingival changes were noted and vitality tests made. As was to be expected, composites, particularly class 2-fillings, showed more loss of substance than amalgams. The latter, however, had a worsening marginal adaptation with increasing age. Secondary caries was generally more frequent in subgingival fillings. The quality of the material was of smaller importance than the marginal leakage. Inflammatory processes of the gingiva were more frequent with composites than with inlays. Gradually increasing discolorations were the rule. Very few teeth lost their vitality after treatment, irrespective of the bases (normal, direct and indirect capping).

Adult

[Transitory bacteremia in rectoscopy].

A prospective study was undertaken to determine the frequency of transient bacteremia on recto-sigmoidoscopy. Blood specimens were drawn for aerobic and anaerobic bacterial culture immediately before, and 1, 5, 10, 15, 20, 25 and 30 min after the beginning of recto-sigmoidoscopy. 19 blood cultures were supposed to be contaminated. In 3 patients (6%) a positive blood culture was found with the following types of organisms: enterococci, Escherichia coli and nonhemolytic streptococci. The need for antibiotic prophylaxis in patients with valvular heart diseases or prosthetic valves is discussed. In such cases the authors propose prophylaxis with 1 g streptomycin i.m. and 3 g ampicillin by mouth 30 min before recto-sigmoidoscopy.

Anti-Bacterial Agents

Macrophage turnover in Crohn's disease and ulcerative colitis.

Monocytopoietic proliferation activity was determined in 8 patients during severe attacks of Crohn's disease and in 6 patients with ulcerative colitis. Similar results were obtained in both groups of patients. A moderate but significant hyperproliferation of monocytopoiesis was found to be present in about half of the patients, and with some of the remainder of cases, part of the criteria for hyperproliferation were also fulfilled. This indicates that Crohn's disease as well as ulcerative colitis are frequently associated with moderate overproduction of monocytes which may be assumed to be induced by macrophage demand of the affected tissues. In comparison with other diseases involving inflammations, the monocytopoietic hyperproliferation was moderate. Therefore, the inflammation in Crohn's disease and ulcerative colitis seems to be characterized by a relatively low macrophage turnover induced by pathogenetic mechanisms of moderate macrophage toxicity.

Adolescent

[Swiss family with chronic relapsing calcifying pancreatitis].

A further Swiss family with hereditary chronic relapsing pancreatitis is reported. Five members definitely have the disease, while in 4 subjects the condition is suspected. The five proven cases are a mother and her four children. All suffer from recurrent attacks of abdominal pain which started between the 8th and 20th year of life, and in all of them exocrine pancreatic insufficiency and pancreatic calcifications can be demonstrated. The mother has had diabetes mellitus since the age of 40 and 3 of the 4 children also have the disease, with age of onset between 15 and 29. In 3 patients insignificant traces of aminoacids could be detected in the urine. At 16 years one male patient had a pseudocyst of the pancreas surgically removed. All the others are treated conservatively. Reports on approximately 25 families with this disease have been published so far. The condition is inherited as an autosomal dominant disorder. Typically, the clinical symptoms begin during childhood or early adolescent life. The pathogenesis is unknown. It is possible that an abnormal pancreatic juice is produced which causes the intracanalicular calcifications. The treatment is identical to that in the non-hereditary forms, i.e. generally conservative. Recently some authors have favored a more aggressive approach consisting of pancreatico-jejunostomy or partial resection of the pancreas.

Adolescent

[Contribution of cases to the new classification of polyposis syndrome in the gastrointestinal tract].

In Schweizerische Medizinische Wochenschrift 106, 894-897 (1976) an article was published on a kinship with hereditary "minor adenomatous polyposis" of the colon with a higher than expected incidence of carcinoma of the stomach. Evidence for a genetic relationship between this family (Sch.) and another branch with an isolated case (Sch. E.) of familial polyposis of the gastrointestinal tract was found. The patient Sch. E. is presented here. The polyposis of this patient is phenotypically identical with that found in the classical familial polyposis of the colon, but also exhibits features of "minor adenomatous polyposis". A systematic clinical-endoscopic examination of ten members of the patient's family produced no further cases of gastrointestinal polyposis of carcinomata. In the case of Sch. E., therefore, a spontaneous mutation is postulated. A new classification of the various types of colonic polyposis is suggested.

Adult