Biomedical subjects
Publications and source records attributed to B Harlan.
This study investigated the reliability of a historical interview with 20 respondents with physical disabilities. An existing interview, the Occupational Role History, was modified and a companion rating scale was developed. Analysis of the test-retest and interrater reliabilities suggest that a stable clinical judgment can be formed from data gathered in a historical interview.
The Starr-Edwards model 6400/10 mitral and 2400/10 aortic valve prostheses incorporate metallic tracks on the inner aspects of cloth-covered struts in an attempt to preserve the favorable thromboembolic performance of cloth-covered valves while avoiding the risk of cloth wear. Two hundred severity operative survivors of mitral valve replacement with the model 6400/10 prosthesis, all on continuous anticoagulant therapy, have been followed up for a mean period of 2.3 (maximal 6) years. The late survival rate is 91 percent and the removal-free rate is 94 percent at 5 years. The rate of embolism (mean +/- standard error of the mean) is 4.6 +/- 0.9 percent per patient-year. Significant bleeding complications occurred at a rate of 1.0 +/- 0.2 percent per patient-year; there were no deaths. Two hundred forty operative survivors of aortic valve replacement with a model 2400/10 prosthesis, all on continuous anticoagulant therapy, have been followed up for a mean of 2.0 (maximal 7) years. The 5 year survival rate is 84 percent and the removal-free rate is 98 percent. Embolism occurred at a rate of 3.3 +/- 0.8 percnet per patient-year. Hemorrhagic complications occurred at a rate of 2.1 +/- 0.6 percent per patient-year; there were three families. Cloth wear and hemolysis have not been significant problems with this prosthesis, and the rates of thromboembolism are comparable with those reported for xenograft bioprostheses. The composite strut (track) valve prosthesis is a durable alternative to tissue valves in patients who are able to tolerate anticoagulant therapy.
This study was designated to document the changes in the CNS response to ethanol during chronic exposure in 5 male, 3.5--5.0 kg rhesus monkeys. Electrodes were implanted bilaterally into the amygdala, hippocampus and the calvarium over the frontal and temporal cortex. Ethanol or control solutions were administered intragastrically through indwelling cannulae. The 1.25 g/kg ethanol challenge dose was administered during EEG recordings. After one challenge dose, the animals received 60 days of chronic alcohol exposure (3.0 g/kg/day increasing to 8.0 g/kg/day). EEG was recorded every 10 days and analyzed by period analysis. Changes in the effect of the challenge dose were assessed by determining the percentage change of the EEG from pre-dose levels to selected times post-dose throughout the chronic alcohol exposure. The EEG response changed significantly during chronic alcohol treatment. Although each structure exhibited a slightly different pattern of change, the overall change was a shift from an excitatory response in the non-tolerant animal to an EEG slowing during chronic exposure. We suggest that such a change may be useful as a diagnostic marker for alcohol tolerance. In addition, the differential nature of the in vivo expression of alcohol tolerance in each brain area suggests that such analysis may provide a valuable tool for understanding the mechanism and expression of alcohol tolerance in the CNS.
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