Biomedical subjects

B Hauser

Publications and source records attributed to B Hauser.

113 records · Page 7Linked to original sources

PubMedDate not supplied

[The diagnostic value of venous blood gas parameters and pH value in newborn foals with pulmonary diseases].

Analysis of blood gases in equine neonatology is regarded as a diagnostic tool to study the neonatal adaptation period. Aim of this study therefore was to compare the diagnostic value of venous blood gas parameters to arterial parameters in newborn foals with pulmonary disorders. Venous as well as arterial blood samples were taken from 24 foals (1 to 6 days old) and the partial pressure of oxygen (pO2), partial pressure of carbon dioxide (pCO2), pH, and oxygen parturition (S-O2) of these samples were investigated. In addition, the alveolar (A) to arterial (a) gradients (A-aDO2) were calculated. Due to changes in blood gas parameters during the first week postnatal the age was taken into consideration by using covariance analysis. All arterial parameters except paCO2 showed a significant difference among healthy foals (n = 15) and foals with respiratory disorders (n = 11) with A-aDO2 and paO2 being the most reliable arterial parameters. In venous blood there was a significant difference between healthy and sick foals only in S-O2 and pH.

Animals↗

PubMedDate not supplied

Helicobacter pylori positivity in Belgium.

Epidemiological data about the prevalence of Helicobacter pylori positivity are presented in a large population of symptom-free paediatric and adult patients in Belgium (n: 1180, age range: 1 to 40 years). The investigated patients belonged to different ethnic backgrounds and are representative for the general population of Brussels. The overall prevalence of Helicobacter pylori positivity was 18.0%. We observed a significant increase in the number of positive patients with advancing age, ranging from 6.4% in the youngest age group (1 to 5 years) to 36.4% in the age group from 36 to 40. Furthermore, a significantly higher prevalence was observed in non-Caucasian patients when compared to caucasian subjects, even if both groups were born in Belgium and have been living in the same area ever since (p < 0.001). We conclude that the overall prevalence of Helicobacter pylori positivity in asymptomatic subjects in Belgium should not be underestimated. Their number increases with age and there are significant ethnic differences. The meaning of these "asymptomatic carriers" still needs to be elucidated, but their prevalence should be considered in future studies about the role of Helicobacter pylori in upper gastro-intestinal pathology.

Adolescent↗

PubMedDate not supplied

Validation of a new serologic test for the detection of Helicobacter pylori.

In order to determine normal ranges for positive and negative titres using a new commercially available second generation serologic ELISA test for the detection of Helicobacter pylori IgG antibodies (Malakit by Biolab, Limal, Belgium) we investigated 560 asymptomatic pregnant women aged 20 to 44. 128 patients (22.9%) had a positive titre for Helicobacter pylori. Although we were able to observe an increase of the number of seropositive subjects with advancing age, a significant increase in titre with age, both for positive and negative titres, could not be demonstrated. Although there was a much higher prevalence of Helicobacter pylori seropositivity in patients with a non-caucasian ethnic background, we did not observe a significant difference in cut-off limit between the different ethnic populations. In all seropositive patients a control serology and 13C-urea breath test were performed 4 to 6 months later. In 124 patients (96.9%) both control examinations were positive. The positivity of the 13C-urea breath test suggests an existent Helicobacter pylori infection in these (symptom-free) women. 13C-urea breath tests were also performed in 100 randomly selected seronegative women and were all negative, as well. Since 13C-urea breath tests were positive in seropositive subjects and negative in seronegative women, we validated the manufacturer's previously established cut-off values, based on only 37 adult patients, in a much larger population.

Adult↗

PubMedDate not supplied

The role of "occult" gastroesophageal reflux in chronic pulmonary disease in children.

It has repeatedly been demonstrated that a correlation exists between gastroesophageal reflux and the presence of various "atypical" complaints, such as recurrent chest pain, apneic attacks in infants, and recurrent or chronic respiratory symptoms. Very recently it has been shown that gastroesophageal reflux is frequently associated with non-controlled asthma in children and that medical treatment for reflux can improve the further course of respiratory disease. The aim of the present study was to investigate a possible cause-relationship between recurrent respiratory symptoms in children and the presence of gastroesophageal reflux disease, and to investigate the value of continuous 24-hour esophageal pH-monitoring in the diagnosis and management of these complaints in 62 children with chronic respiratory disease. Continuous 24-hour pH-monitoring was abnormal in 39/62 patients (62.9%). However, no statistically significant correlation could be detected between the presence of gastroesophageal reflux and various anamnestic parameters (parental smoking, pet in household, sibling with gastroesophageal reflux disease), or concomitant atopy. All children that were found positive for gastroesophageal reflux (n = 39) were started on an antireflux therapy (cisapride 0.2 mg/kg q.i.d.). This treatment resulted in an improvement of the symptoms in 84.6%. We conclude that gastroesophageal reflux is an important (causative) factor in chronic recurrent respiratory disease. This entity is often resistant to "classical" respiratory treatment, but can be treated with an anti-reflux therapy. We, therefore, suggest to perform continuous 24-hour esophageal pH-monitorings as a standard procedure in all patients with recurrent respiratory complaints, independent of the severity of their symptoms.

Adolescent↗

PubMedDate not supplied

Nutritional value of an "anti-regurgitation" formula.

OBJECTIVES: Anti-regurgitation formulae are recommended in the therapeutic approach of regurgitation. However, their nutritional value needs to be evaluated. It is not known whether the addition of (fibers of) bean gum might influence the intestinal absorption of nutrients and minerals. PATIENTS: Fourty healthy infants were included in an open randomised prospective trial, receiving either a regular adapted (casein/whey ratio 40/60) or an anti-regurgitation (casein/whey ratio 80/20) formula. RESULTS: At the end of the study, at the age of 13 weeks, weight and length gain, and most serum parameters (iron, iron binding capacity, calcium, phosphorus, protein, prealbumin, zinc) were comparable in the 20 infants in each group. The mean intake per day was higher in the anti-regurgitation formula group (755 +/- 55 versus 680 +/- 89 ml/day; p < 0.001), resulting in a higher protein intake (12.80 versus 9.52 g; p < 0.001), which might explain the increased plasma urea level in this group (23.1 versus 15.9 mg/dl; p < 0.001). The albumin level, on the contrary, was smaller in the anti-regurgitation group (4.21 versus 4.85 g/dl; p < 0.001). CONCLUSION: All nutrition parameters are within normal ranges, although there are some significant differences between both groups (for urea and albumin). However, the formula should also be evaluated in therapeutic conditions in regurgitating babies. Differences in intake might be related to the selection of the study population, which were asymptomatic babies.

Body Height↗