PubMed Health⌕ Search

Biomedical subjects

B Hausmann

Publications and source records attributed to B Hausmann.

44 records · Page 3Linked to original sources
PubMed1980

Expression of the I-E target antigen for T-cell killing requires two genes.

The H-2Ik region encodes at least two different target antigens for unrestricted T-cell mediated killing. The first is controlled by the I-A region alone and the second depends on a pair of alleles, one located to the left of I-B (presumably in I-A) and the other to the right of I-J (presumably in I-E). Hence, effector cells nominally specific for a product of the I-E region do not kill target cells with the same I-E region as the stimulator unless the I-A region is also shared. Some effectors specific for H-2Ik, such as A.TH anti-A.TL and B10.A(4R) anti-B10.A(2R), cross-react with B10.A(3R) and B10.A(5R) target cells. A product of the H-2b haplotype was shown to complement products of the H-2d or H-2k haplotypes in forming this cross-reactive determinant. The results are consistent with recent biochemical data on the component chains of Ia antigens.

Animals↗
PubMed1979

Separation of human cells bearing HLA-DR antigens using a monoclonal antibody rosetting method.

A technique is described for enriching, from human blood, cells bearing HLA-DR antigens. The method depends on the use of monoclonal mouse antibody which reacts with HLA-DR structures. Cells to which this antibody has bound can be separated after rosetting with bovine erythrocytes coated with anti-mouse immunoglobulin. The cells thus enriched may be used for HLA-DR typing by standard cytotoxicity methods with allogeneic sera.

Antibodies, Anti-Idiotypic↗
PubMedDate not supplied

A new H-2-linked class I gene whose expression depends on a maternally inherited factor.

The maternally transmitted antigen (Mta) is expressed on the cells of most strains of mice. It is a medial histocompatibility antigen, that is, it is recognized by unrestricted cytotoxic T lymphocytes as are major H antigens, but unlike these it is a weak transplantation antigen and does not itself restrict the T-cell recognition of minor H antigens. All other medial H antigens are encoded by genes closely linked to the major histocompatibility complex, H-2 in the mouse. By contrast, Mta appeared to follow extrachromosomal, maternal inheritance. Several substrains of NZB, NZO and non-inbred European NMRI mice are Mta-negative. Females of these strains bear only Mta- offspring, while females of the inbred Mta+ strains bear only Mta+ offspring. Repeated backcrossing from Mta+ females to NZB or NMRI males has shown that, given the right cytoplasmic genes, the chromosomal genes of these Mta- strains permit expression of Mta2. As the Mta type of a mouse cannot be influenced by embryo transfer or foster nursing, we concluded that it was determined by a cytoplasmic factor (Mtf), transmitted through the egg. We now show that a gene, Hmt, closely linked to the H-2 complex, is also required for expression of Mta.

Alleles↗
PubMedDate not supplied

[Planimetric studies of the lumbar intervertebral space following nucleotomy by straight and angled rongeur].

Persisting, floating intervertebral disc sequesters after lumbar nucleotomy are one reason for recidivation of disc prolapses. For this reason, planimetric experiments at a lumbar intervertebral disc's cross-section are made using straight and angled forceps to estimate the maximum possible amount of curetted intervertebral material. The results show that, at the very best, no more than 70% of the intervertebral area can be reached by the common straight and angled forceps.

Humans↗
PubMedDate not supplied

[Quantitative studies of the "cleared out intervertebral disk space" following nucleotomies].

Operative removal of prolapsed intervertebral disk's tissue combined with nucleotomy represents nowa days a routine operative treatment. It is left to the surgeon to clear out - more ore less totally - the intervertebral disk interspace. It can be proved, that based on operation site's anatomy and the disposal instrumentarium the total "clear out" of intervertebral tissue doesn't succeed.

Cadaver↗
PubMedDate not supplied

[Demonstration of possible damage to the knee joint during arthroscopy].

The possible damage of the cartilaginous surface of the knee which may be caused during arthroscopy by the insertion of the trocar into the knee-joint is described. The mechanism of internal cartilaginous surface damage is photographically recorded using an additional documentation-arthroscope. If the intraarticular pressure of the knee-joint is increased before insertion of the arthroscope, damage to the inside of the knee-joint can be essentially reduced.

Arthroscopy↗
PubMedDate not supplied

Variants of Mta, the mouse maternally transmitted antigen, determined by three alleles of the extrachromosomal gene Mtf.

Two new forms of Mta, the maternally transmitted antigen of the mouse, were defined by cytotoxic T lymphocytes. One is found in laboratory mice carrying the beta allele of the maternally transmitted factor, Mtf, which were previously thought to be Mta-negative. The other is associated with a new allele, Mtf gamma, and is found in wild mice from Toulouse. Like the common form of Mta, determined by the extrachromosomal Mtf alpha, the new forms are also dependent on the a allele of Hmt, a chromosomal gene linked to H-2, and are associated with beta 2-microglobulin. Killers could be raised in all six combinations of alpha, beta, and gamma mice, showing that each form of Mtf determines a distinct (set of) epitope(s). We propose that the product of the Hmt gene, a class I MHC antigen, presents a peptide derived from a mitochondrial gene product on the cell surface and thereby creates the target antigen, Mta.

Alleles↗