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Biomedical subjects

B Heinen

Publications and source records attributed to B Heinen.

4 recordsLinked to original sources
PubMed2000

Duplication of 1q in a child with down syndrome and myelodysplastic syndrome.

Cytogenetic analysis of bone marrow cells was performed on a 2-year-old African-American male with Down syndrome (DS) and myelodysplastic syndrome (MDS), specifically refractory anemia with excess blasts in transformation (RAEB-T). Chromosome analysis showed, in addition to the constitutional trisomy 21, a trisomy of chromosome 11 and a dup(1)(q23q31). This duplication of 1q is apparently a new chromosomal abnormality in a child with MDS. Partial trisomy of the long arm of chromosome 1 has been reported by several authors and appears to represent a nonrandom chromosomal anomaly in patients with MDS/acute myelogenous leukemia and DS.

Anemia, Refractory, with Excess of Blasts↗
PubMed1987

The excretion of renal enzymes during rest and exercise: a double-blind comparison between placebo and penbutolol.

A double-blind cross-over study was carried out in five healthy male volunteers to investigate the renal tolerance of 40 mg penbutolol, a receptor-specific beta-blocking agent, during exercise and to compare its effects with a placebo. The effects of exercise were compared with a resting state after a medication on the placebo. Urine was collected in fractions for seven hours on each trial day. The urine volume and the excretion of alanine aminopeptidase (AAP), N-acetyl-beta-D-glucosaminidase (NAG) and gamma glutamyltransferase (GGT) per fraction were determined. The findings for the kidney enzymes AAP, NAG and GGT show that the renal tolerance of penbutolol was good. Physical exercise per se did not cause any increase in the excretion of the above-mentioned enzymes. Slight diurnal variation was seen in the excretion of the renal enzymes after both the placebo and penbutolol.

Acetylglucosaminidase↗
PubMed1987

Serum trace-element levels in piretanide-treated hypertensives: a double-blind trial against hydrochlorothiazide plus amiloride.

A double-blind parallel group study was carried out in patients with mild to moderate hypertension to assess the effects of 6 mg piretanide once or twice daily, in comparison to 50 mg hydrochlorothiazide plus 5 mg amiloride once daily, on serum trace-element levels over a period of three months. The results showed that for most of the trace elements investigated (zinc, iron, copper, manganese and cobalt) no relevant changes were seen. Only serum iron values (medians) showed a slight drop (p less than 0.05) with 6 mg piretanide twice daily. The results indicate that a three-months' therapy with piretanide or with a thiazide-potassium sparer diuretic combination is safe without producing any disturbances in the serum levels of trace elements.

Adult↗