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B Heinze

Publications and source records attributed to B Heinze.

41 records · Page 3Linked to original sources
PubMed1986

Pharmacopsychological effects of flunarizine in geriatric patients with light brainorganic psychosyndrome. Preliminary communication.

The effects of the cerebral calcium antagonist flunarizine in 50 geriatric patients with light brainorganic psychosyndrome were determined in the course of a 12 weeks' placebo-controlled pharmacopsychological double-blind study. Factor analysis on the basis of 19 individual psychological tests served as multivariate evaluation model. Advantages of flunarizine became evident in factors 1 (contentedness), 3 (alertness) and 4 (good memory/sound sleep). The increased performance (factor 2) in both groups may well be due to a training effect and would, therefore, be artificial.

Aged↗
PubMedDate not supplied

Karyotype abnormalities and their clinical significance in blast crisis of chronic myeloid leukemia.

We examined karyotypes and their prognostic significance in a series of 122 patients with chronic myeloid leukemia in blast crisis. Of 73 patients cytogenetically examined at the onset of blast crisis 63% had developed secondary cytogenetic abnormalities in addition to the Philadelphia chromosome. These newly emerging abnormalities included a double Philadelphia chromosome in 20 patients, a trisomy 8 in 17, and an isochromosome 17q in 11 patients. Development of such additional karyotypic abnormalities was significantly associated with a shorter median survival and less response to cytoreductive treatment and was significantly more common in nonlymphoid blast crisis than in the lymphoid-type blast crisis. Thus, assessment of karyotypes at the onset of chronic myeloid leukemia blast crisis appears to be of prognostic significance for both remission duration and survival.

Blast Crisis↗