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Biomedical subjects

B Holmström

Publications and source records attributed to B Holmström.

At least 73 records · Page 4Linked to original sources
PubMed1981

The physiological activity of human faecal flora evaluated by determination of germfree animal characteristics.

Germfree animals exhibit specific physiological signs which have been labeled germfree animal characteristics. Such characteristics have been used in animals and in man to evaluate the influence of antibiotics on the intestinal flora. In order to evaluate the feasibility of using germfree animal characteristics in the evaluation of the intestinal flora in man, out-patients and hospitalized patients without gastrointestinal disorders were investigated. All patients were on a normal diet and had not been treated with antibiotics the year prior to the study. Samples of faeces were obtained at routine controls or after 10-14 days in hospital and analyzed for coprostanol to cholesterol ratios, mucin and stercobilin contents and proteolytic and tryptic activity. No differences were observed between out-patients and hospitalized patients. The germfree animal characteristics was of the same order of magnitude in man as in conventional animals.

Adult↗
PubMed1980

Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease.

During the period 1955 to 1974 inclusive, 826 patients developed Crohn's disease and were registered citizens of Stockholm County at the time of definite diagnosis. These patients were followed up and investigated with reference to the occurrence of and outcome after treatment for anal fistulae. These fistulae were recorded in 184 patients (23%). The incidence of anal fistulae increased the further distally the intestinal lesion was located. Healing followed local operation for anal fistula before curative intestinal resection in approximately 60% of the patients with small intestinal and combined ileocolic disease. However, patients with colonic Crohn's disease did not heal after such treatment. When curative intestinal resection was the primary procedure, 47% of the patients healed spontaneously. Small intestinal and combined ileocolic disease was associated with a good prognosis--90% were healed at follow-up, while patients with colonic disease had a poor prognosis. The combination of rectal Crohn's disease and anal fistula invariably led to proctocolectomy.

Adolescent↗
PubMed1980

Malignant tumours of the colon and rectum in patients aged 30 and younger.

Hospital records of the 27 patients, aged 30 years or younger, with carcinoma of the colon or rectum diagnosed 1969--1970, were reviewed. Predisposing diseases were found in 12 cases, 10 of these did not survive 5 years. Of 15 patients without predisposing disease 9 survived 5 years. The material is small but the prognosis does not seem to be worse in young patients with colonic cancer compared to elderly, provided the tumour has not developed from a predisposing disease. In such cases an early prophylactic operation must always be considered.

Adult↗
PubMed1980

Carcinoids of the colon and rectum in patients aged 30 and younger.

Carcinoid tumours of the colon and rectum were diagnosed in 26 patients, 30 years or younger, in Sweden during 1969--1970. Patho-anatomical description was adequate in 24 cases and of these 23 were localized to the appendix and one to the caecum. The treatment was appendicectomy and in the last case ceacal resection. None of the patients had carcinoid syndrom. One patient was lost at follow-up, the 5-year survival rate of the remaining 25 patients was 100 per cent.

Adolescent↗
PubMed1980

Outcome following treatment of anal fistulae in Crohn's disease.

The results of treating 24 patients with anal fistulae and active intestinal Crohn's disease is reported. Four patients had multiple extended, seven high and ten low fistulae and three patients had sinus tracts. Seven patients with only minor discomfort were treated conservatively and five of them healed. Thirteen were treated by local surgery and ten subsequently healed. Four patients with rectal Crohn's disease and multiple fitulous systems were submitted to abdominoperineal excision. These results indicate that in patients without rectal involvement, conservative treatment and local surgery is indicated.

Adult↗
PubMed1980

Anal tuberculosis. A report of two cases.

Two cases of anal tuberculosis are reported. One presented as an ulceration in the anal canal and the other as an anal abscess and fistula. Both were diagnostic problems, tuberculosis was not suspected at first. Both were cured, one by medical treatment, the other by combined surgical and medical treatment.

Aged↗
PubMed1980

Influence on symptoms and transit-time of Vi-SiblinR in diverticular disease.

Nine patients complaining of constipation and with diverticuli of the colon on barium-enema were examined with regard to transit-time, bowel movements and subjective symptoms. They were treated with placebo and Vi-SiblinR, using a doubleblind cross-over technique. The transit-time remained normal during the Vi-SiblinR treatment. The feces became softer and increased in weight and the subjective symptoms were significantly reduced (p less than 0,05).

Aged↗
PubMed1979

Carcinoma of Meckel's diverticulum.

Acute intestinal obstruction in a women, aged 56, was caused by a highly malignant adenocarcinoma arising in a Meckel's diverticulum. Despite radical surgery, the tumour recurred after four months, and the patient died nine months after her first operation. This confirms the general bad prognosis associated with carcimomas of Meckel's diverticulum.

Adenocarcinoma↗
PubMed1978

Decreasing frequency of cholecystectomies in the counties of Stockholm and Uppsala, Sweden.

The frequency of cholecystectomies was followed in the counties of Stockholm and Uppsala during an eight-year period (1969--1976). In both counties there was a highly significant decrease. This was mostly marked for males under 50 and females under 40 years in Stockholm and for females, regardless of age, in Uppsala. It is unlikely that these figures represent a decrease in the prevalence of gall-stone disease even if a small change is possible. A major alteration in the financing system of out-patient care has taken place during the investigated period and this has probably had an important influence on the cholecystectomy rate. Another important factor may be the consideration of a etiological factors other than gall-stones for minor abdominal disorders.

Adolescent↗
PubMed1978

Negative findings in search for a transmissible agent in Crohn's disease.

Affected lymph nodes from 3 patients with Crohn's disease were homogenised and inoculated intramurally into the distal ileum of five piglets. The homogenates were also inoculated intramurally in the distal ileum of 15 rats and also by percutaneous injection intraabdominally in 15 rats and compared with the same number of animals of each species inoculated in the same manner with homogenates prepared from 3 patients with caecal cancer. There was no difference in weight increase between the animals inoculated with Crohn's tissue homogenate or control tissue homogenate. Neither did we find any macroscopic or microscopic changes in the animals inoculated with Crohn's tissue homogenate. We found a rather high frequency of mammary tumors in the rats inoculated with Crohn's tissue homogenate, although compared to the rats inoculated with control tissue homogenate there was no statistically significant difference. The negative results may be due to the method of preparing the tissue homogenate or to the use of lymph nodes instead of the bowel in preparing the homogenate, but may also be taken as support against the suggestion that a transmissible agent is present in Crohn's disease.

Animals↗
PubMed1978

Contamination of germfree animals with intestinal Crohn tissue. A preliminary report.

The preliminary results of one of a series of prospective studies in the investigation of a possible transmissible agent in Crohn's disease are presented. Filtered human Crohn tissue homogenates was inoculated into eight germfree Sprague-Dawley rats, to test the reproducibility of recent reports suggesting a transmissible agent in regional ileitis. No histological changes were evident after 150 days, and no changes were observed in animals inoculated with non-Crohn tissue homogenates.

Animals↗