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Biomedical subjects

B Hortian

Publications and source records attributed to B Hortian.

9 recordsLinked to original sources
PubMed1997

[Differentiated characterization of pulmonary diffusion].

The results of Single-Breath-Test with carbon monoxide offers only a rough estimation of the gas exchange situation in the lung as concerns pulmonary diffusion capacity. This statement is related to overestimation of diffusion capacity and reduced possibility to characterize disturbances of pulmonary diffusion function on the basis of values assessed. The proposed six-array-diagram offers the possibility to characterize the disturbances of diffusion more exactly and to differentiate them simultaneously regarding the values determined. So it is possible, to characterize better structural changes of the blood-gas barrier of the lung and to demonstrate compensatory mechanisms.

Breath Tests↗
PubMed1997

[Relationship between respiratory reserve in the flow-volume curve and the expected ergometric capacity].

To evaluate the physical work capacity in patients with chronic obstructive lung disease (COLD) it was checked, if determination of breathing reserve can replace the exercise test with blood gas analysis. In 28 patients with lung disease and 7 healthy subjects the flow-volume-curve under resting conditions and during the forced breathing maneuver to measure the breathing reserve and the exercise test with blood gas analysis were examined. A correlation was found between both. Therefore, in patients with COLD the determination of breathing reserve is a practicable method for estimating the physical work capacity, especially in cases with absent breathing reserve. Nevertheless, for medical opinion exercise testing is necessary.

Blood Gas Analysis↗
PubMed1993

Determination of glomerular filtration rate (GFR) on two consecutive days using inulin in a single-sample plasma clearance method.

Reliable estimation of the GFR is essential in nephrological practice for the early recognition and follow-up of latent or residual renal disturbance. The GFR of ten healthy volunteers on two consecutive days and of 40 patients with different renal diseases were investigated by means of a plasma slope clearance technique. After injection of 5 g/50 ml inulin solution, eight plasma samples were taken at 10, 20, 30, 40, 120, 180, 240, 300 min p.i. and analyzed with the aid of a fully enzymatic method. The results were correlated on the basis of 1- and 2-compartment models (1 CM, 2 CM) and the one-sample method (1 S), using only the plasma inulin concentration of the 240 min p.i. sample. The accuracy of the GFR data of volunteers estimated in these models was checked by comparison with the standardized agewise normal values, while for the patient group we found in terms of equations of correlation: 1. GFR (2 CM) = 4.46 + 0.763*GFR (1 S), n = 31, r = 0.985 2. GFR (2 CM) = 1.27*GFR (1 CM)0.9, n = 40, r = 0.996 3. GFR (1 CM) = 0.568*(GFR[1 S] + 5.85)1.11, derived The single-sample method using inulin is closely correlated to multi-sample methods but much more suitable for patients and staff. Therefore, it is recommended for clinical use.

Adult↗
PubMed1991

[Reproducible determination of the glomerular filtration rate (GFR) and the effective renal plasma flow (ERPF) in conscious rats using inulin and p-aminohippuric acid].

Estimation of the glomerular filtration rate (GFR) and of the effective renal plasma flow (ERPF) by means of the test substances inulin and p-aminohippuric acid according to the steady state clearance measurement during the drop of the plasma level after the initially injection of an depot of the indicators was examined methodologically. The procedure should be repeatable in the same animal under conscious conditions. The results demonstrate that the described method is adequate with regard to accuracy, reproducibility and sensitivity for the estimation of the GFR, whereas limitations apply to calculation of the ERPF.

Animals↗
PubMed1990

[Ergometric results of r-erythropoietin treatment of hemodialysis patients].

To investigate the effect of partial correction of anemia in patients maintained by chronic intermittent hemodialysis on exercise capacity, patients underwent a bicycle acido-ergometry before and after treatment with recombinant human erythropoietin. The results demonstrate a (subjective) improvement of exercise capacity without any evidence for that in the pH values.

Acid-Base Equilibrium↗
PubMed1990

[Simultaneous determination of the GRF and the ERPF (effective renal plasma flow) using a single blood sample in the slope clearance with 99mTc-DTPA and I 131-hippurate].

In patients with various indications to renal split function diagnostics the plasma slope clearance of the Tc99m-DTPA and J131-Hippurate to the estimation of GFR and ERPF were performed with two or three blood samples in the monocompartment model (1 KM). In comparison these functional parameters were calculated on the basis of the only least blood sample (single-point procedure--EPV). The results of linear regression GFR (1 KM) = 12.7 + 0.978 * GFR (EPV), r = 0.986, N = 102 or ERPF (1 KM) = 22 + 1.13 * ERPF (EPV), r = 0.889, N = 68 may recommend the use as patient-safe procedure especially in poor venous access. Two short BASIC programs for estimation of GFR and ERPF are presented and the error ranges discussed.

Adult↗
PubMed1990

[Effect of indomethacin on the vital prognosis and homeostasis of rats with kidney insufficiency].

The medicamentous-therapeutic modulation of pathogenic hyperfiltration of residual nephrons by the prostaglandin synthesis inhibitor indomethacin was evaluated again. The experimental study of inbred wistar rats including a low indomethacin dosage of 1.5 mg/kg BW, a strong reduction of renal parenchyma (80%) and an increased food protein content of 40% did show the known results: indomethacin may impair the vital prognosis of severe renal injury.

Animals↗
PubMed1988

[Contribution of animal experiments in the problem of a long-term indomethacin therapy in advanced nephron loss].

Residual nephrons are subject to compensatory adaptation at which the glomerular hyperfiltration and convection of macromolecules (proteins) are of pathogenic character in the progression of nephropathy. The influence of indomethacin at dosages of 2 or 3 mg/kg body weight/day was investigated in long-term feeding trials (8 months) on inbred female Wistar rats after unilateral nephrectomy and additional resection of both kidney poles. The results show a significant deterioration of vital prognosis under indomethacin medication independently of the dosage.

Animals↗