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Biomedical subjects

B Husberg

Publications and source records attributed to B Husberg.

At least 55 records · Page 3Linked to original sources
PubMed1987

Postoperative deep venous thrombosis after renal transplantation. Effects of cyclosporine.

In this prospective study the frequency of deep venous thrombosis during the first three weeks after renal transplantation was determined using a combination of strain gauge plethysmography and thermography for objective diagnosis. Ninety-seven consecutive patients were studied, 30 patients having juvenile diabetes mellitus. As immunosuppression cyclosporine and low-dose steroids were used. The series was compared with a similar group of 83 patients, 33 having juvenile diabetes mellitus treated with azathioprine and high-dose steroids as immunosuppression, in which the diagnosis of deep venous thrombosis was made with an identical technique. The overall frequency of thrombosis was 9.3% in the cyclosporine-treated group, which is a significant reduction in comparison with the azathioprine group (24.1%). It is concluded that the combination of cyclosporine and low-dose steroids does not increase the frequency of deep venous thrombosis in comparison with azathioprine and high-dose steroids in renal transplanted patients.

Adolescent↗
PubMed1986

HLA-matching and pretransplant blood transfusions in cadaveric renal transplantation--a changing picture with cyclosporin.

613 patients were included in a study to assess the extent to which HLA-matching and pretransplant blood transfusions affect the outcome of cadaveric renal transplantation in patients treated with cyclosporin and low doses of prednisolone. Matching for the HLA-DR-antigens significantly reduced the frequency of rejection episodes, but neither HLA-matching nor pretransplant blood transfusions influenced the patient and graft survival rates.

Analysis of Variance↗
PubMed1986

HLA-matching in cyclosporine treated renal transplant recipients: a prospective Swedish-Norwegian multicenter study.

1. In this prospective study of 613 CD and 205 one haplotype mismatched LRD transplant recipients treated with CyA, there was no influence of HLA-matching (A, B, DR or combinations) on graft survival rate at one and two years. 2. Patients who successfully received HLA-DR-matched kidneys (CD or LRD) had fewer rejection episodes during the first six months after transplantation. 3. Three factors significantly reduced the cadaveric graft survival rate: (a) presence of panel reactive T-cell antibodies in a current recipient serum, (b) cold ischemia time beyond 27 hours, and (c) recipient age above 55 years. 4. The survival rate of one haplotype mismatched LRD kidneys was excellent and is considered to be the optimal treatment for uremia also in CyA-treated patients. 5. Based on this study, exchange of well HLA-matched CD kidneys to non-sensitized patients has been terminated provisionally in Scandia-transplant. Exchange of HLA-A, B-matched kidneys will be maintained, however, for sensitized patients inasmuch as this will increase the chance of obtaining a negative cross-match and possibly improve graft survival in this high-risk patient group.

Cyclosporins↗
PubMed1985

Juvenile diabetes mellitus--a risk factor for postoperative venous thromboembolism?

In a retrospective analysis of 125 patients and a prospective evaluation of 83 patients with terminal uremia undergoing kidney transplantation, juvenile diabetes mellitus was found to be a significant risk factor for the development of postoperative thromboembolism. We found a high frequency of objectively verified thromboembolism despite the relatively young age of the patients. Besides diabetes, no other clinical risk factor differed between patients with and without thrombosis.

Adult↗
PubMed1985

Deep vein thrombosis after renal transplantation: a prospective analysis of frequency and risk factors.

In a prospective study the frequency of deep vein thrombosis during the first 3 weeks after kidney transplantation has been evaluated using the combination of thermography and strain-gauge plethysmography for objective diagnosis. 83 consecutive patients were included, 33 with juvenile diabetes mellitus. The overall frequency of thrombosis was 24.1%, diabetes mellitus being a significant risk factor. No other risk factors were found. The transplant did not influence the venous outflow from the corresponding leg. Plasminogen activator activity in the iliac vein wall at transplantation did not differ between patients with and without thrombosis.

Adult↗
PubMed1985

Development of arteriovenous shunts in rejecting rat kidneys.

Arteriovenous shunts in rejecting rat kidneys were studied in vivo by injecting radiolabelled 15-micron microspheres into the graft artery 4-7 days after transplantation. Serum creatinine levels were measured and the transplants were examined microscopically. The radioactivity in the transplanted kidneys, lungs and the hind legs was recorded. A progressive increase in the amount of radioactivity found in the lungs started 5 days after allogenic transplantation but not after isotransplantation. Increased serum creatinine levels were first recorded on day 6 and focal necrosis or hemorrhages were not seen microscopically at any time. The results support the hypothesis that arteriovenous anastomoses are opened or created early as a part of the graft rejection process and not as a late consequence of tissue necrosis.

Animals↗
PubMed1984

Feasibility of extracorporeal on-line large-scale plasma adsorptions on protein A-sepharose columns in cancer patients.

The feasibility of extracorporeal adsorption of 1.5-3 L plasma on protein A-Sepharose was investigated in six patients with advanced cancer. Anticoagulation with heparin was associated with respiratory distress syndrome in two patients, most likely caused by complement activation as indicated by a transient leukopenia during plasma reinfusion and appearance of C3 degradation products in the extracorporeal circulation. Addition of citrate abolished the respiratory symptoms, C3 degradation, and leukopenia, and no adverse reactions were observed. No objective tumor regression was observed in any of the patients. Three patients progressed during therapy. In one of these, multifocal central tumor necrosis was observed as a possible, although unproven, therapeutic effect. Increased natural killer and/or killer cell activities were recorded in three patients and increased complement-dependent serum cytotoxicity in one patient. The level of circulating immune complexes decreased significantly (18-28%) in three patients studied. It is concluded that extracorporeal plasma adsorption on protein A-Sepharose is feasible when citrate is added to the extracorporeal system, but its therapeutic efficacy is uncertain.

Adsorption↗
PubMed1984

Ultrasonography in complications of renal transplantation.

The reliability of ultrasonography in detecting complications of renal transplantation was investigated by reviewing the ultrasound examination on 78 renal transplants. The results of the ultrasound examinations were correlated with all available clinical, laboratory, radiographic, scintigraphic, and histopathologic data. With the exception of one urine leak no extrarenal complications of clinical significance, such as hydronephrosis, urine leak, lymphocele or hematoma were overlooked at ultrasonography. The exact nature of fluid collections was, however, only seldom accurately assessed unless fine needle biopsy was used. The accuracy in detecting both acute and chronic rejection was high with ultrasonography and a normal ultrasonography of a non-functioning kidney was a strong indication of acute tubular necrosis. Ultrasonography was very sensitive in detecting early acute rejection but was of less value in diagnosing repeated acute rejections with short intervals and in monitoring the response of treatment as the sonographic changes of rejection disappeared slowly.

Acute Kidney Injury↗
PubMed1983

Decreased fibrinolytic activity in vessels and ureters of rejecting human kidneys.

Plasminogen activator (PA) activity was determined with a histochemical fibrin slide technique in renal arteries, veins and ureters in 62 transplanted kidneys and again at transplantectomy in 12 transplants who later underwent irreversible rejection. At transplantation PA activity was the same whether the grafts later rejected or not. There was a significantly decreased PA activity in the vessels and ureters in rejected transplants. The role of the fibrinolytic system as a pathogenetic factor in rejected kidneys is discussed.

Adolescent↗