Biomedical subjects

B Hussl

Publications and source records attributed to B Hussl.

At least 37 records · Page 2Linked to original sources

PubMed1979

Urinary androgen- and estrogen excretion in men with pachydermia laryngis and cancer of the larynx.

Considering the larynx as a hormone dependent secondary sex characteristic has previously led to successful antiandrogentherapy of pachydermia of the vocal cords, which may constitute a precancerous state. As a first step to further evaluate the endocrine state of patients with precancerous lesions or cancer of the larynx, the urinary excretion of 17-hydroxysteroids, 17-ketosteroids, testosterone and estrogens has been determined in male patients with pachydermia laryngis (n = 15) or cancer of the larynx (n = 20) as compared to controls with different other otorhino-laryngological affections (n = 20). No difference between groups was found in 17-hydroxysteroids and no significant difference in 17-ketosteroid excretion. The pachydermia group as a whole showed significantly increased levels of testosterone (p = 0.01) and estrogen (p = 0.04) of 64.6 +/- 39.9 microgram/24 hr testosterone versus 34.7 +/- 19.3 microgram/24 hr in controls and 31.7 +/- 16 microgram/24 hr in laryngeal cancer and 277 +/- 14.8 microgram/24 hr total estrogens versus 19.1 +/- 12 microgram/24 hr and 17.8 +/- 8.1 microgram/24 hr respectively. These data further support the idea of hormonal factors playing an important role in the pathogenesis of pachydermia and thus possibly cancer of the larynx. So far, however, they do not permit definite conclusions on the pathogenetic mechanisms involved.

17-Ketosteroids↗

PubMed1979

[Otitis nigra: etiologic pathogenetic and clinical aspects (author's transl)].

The clinical picture of otitis nigra (idiopathic sero-hemmorrhagic otitis media) as independent clinical entity is shown, presenting 5 cases requiring mastoid surgery. Samples of mastoid mucosa were investigated by light- and electron-microscopy employing histochemical, immunofluorescent and virological techniques. Pathological changes of the small vessels in the subepithelial connective tissue with increased vascular permeability and extravasation of red blood cells and serum play a central role in the pathogenetic course of the disease. Disintegration of erythrocytes leads by catabolism of hemoglobin to formation of hemosiderin and ferretin, whereas by processing of phospholipids of the cell-membrane cholesterin cristals are deposited in the connective tissue. These cholesterin deposits in turn induce a foreign body reaction with formation of typical cholesterol granulomas. The mucosa shows secretory activity in intraepithelial secretory cells and glandlike structures in the subepithelial connective tissue. Neutral and acidic mucopolysaccharides are demonstrated in the secretory product. As possible cause for the vascular lesion that in turn sets off the pathomechanisme of otitis nigra a subclinical viral infection is discussed. This conjecture is supported by demonstration of virus-like inclusion bodies in macrophages and fibrocytes and of virus-like particles in antral smears. In addition myxoviruses of the parotitis-epidemica group could be identified in these smears by serological methods. Furthermore, the stimulation of the local immunological defense system, evidenced by the presence of numerous immunoglobulin-producing plasmacells in the tissue, is in concord with a viral infection. Therapy requires mastoidectomy in combination with posterior tympanotomy in order to eradicate completely the intractably diseased mastoid mucosa.

Adolescent↗

PubMed1978

First clinical experiences with hormone-therapy of pachydermia laryngis.

First clinical experiences with the anti-androgenic drug cyproterone-acetate in treatment of pachydermia laryngis are reported in eleven male and female patients. This endocrine therapy led to complete healing in four and to marked improvement in six patients. One did not respond. Evaluation of the endocrine state of these patients showed imbalance in the androgen/estrogen equilibrium. As the larynx constitutes a secondary sex characteristic and an endocrine target organ, the significance of endocrine factors for pathogenesis and therapy of epithelial changes on the vocal cords is discussed.

Androgen Antagonists↗

PubMed1977

Anti-androgen-therapy in pachydermia of the female larynx--a new therapeutic possibility.

Case-report about a 56 year old white female patient with pachydermia laryngis and hirsutism, successfully treated with cyproterone-acetate, a testosterone antagonist. The significance of androgenic hormones for the development of epithelial changes in the female larynx is emphasized. The administration of antiandrogenic substances as a new therapeutic measure is discussed.

17-Hydroxycorticosteroids↗

PubMed1975

[25 years experience with glottis widening surgery in our clinic (author's transl)].

Between 1949 and 1974, 137 patients with bilateral vocal cord paralyses were operated upon in our Department. In 127 cases King's method of extralaryngeal lateral fixation of the vocal cord or a modification thereof was executed on one or both sides. The modification consisted of securing the lateral-fixating suture around the superior thyroid cornu. This produces an additional displacement of the vocal cord in the vertical plane which provides good respiratory function in spite of only moderate lateral displacement of the cord. In seven cases endolaryngeal arytaenoidectomies and submucus hemicordectomies using Kleinsassers' technique were performed. In three cases endo- and extralaryngeal methods were combined. 120 (87.6%) of all patients could be decannulated. After unilateral extralaryngeal lateral cord fixation, 77.2% of patients could be decannulated within three weeks following operation. Operative results were analysed according to respiratory and vocal function two years postoperatively. After unilateral lateral cord fixation, breathing was good or sufficient in 73.6% of cases and insufficient in 26.4% of cases. The voice was normal or dysphonic in 86% of cases while aphonic in 14% of cases. Among the causes of bilateral vocal cord paralysis, primary strumectomies and operations for recurrent goiter were predominant (95%). All patients were tracheotomized before or after the operation. Two years postoperatively, incidental tracheal stenosis was noted in 73% of all patients. This was insignificant to moderate in 63.5% of cases and severe in 9.5% of the cases.

Adult↗

PubMed1973