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Biomedical subjects

B I Hoffbrand

Publications and source records attributed to B I Hoffbrand.

18 recordsLinked to original sources
PubMed1979

Response of neutropenia and anaemia to immunosuppressive therapy: report and bone marrow culture studies.

Soft agar culture of bone marrow cells was used to investigate abnormalities of granulopoiesis in a patient with acquired anaemia and neutropenia which responded to immunosuppressive therapy. Results showed that the patient's peripheral blood leucocytes inhibited granulopoiesis in vitro. Variation in the response of different target marrows suggested that inhibition was not due to direct action on granulocyte-monocyte committed stem cells but was directed against or mediated through the cells in target marrow samples which produce granulopoietic stimulators. Cell separation showed that the inhibitory activity was associated with the patient's mononuclear cells rather than neutrophils. A tentative explanation of the mechanism of production of the anaemia is also offered.

Agranulocytosis↗
PubMed1978

Severe hyponatraemia in hospital inpatients.

A prospective study of severe hyponatraemia in adult hospital inpatients showed that 44 patients had plasma sodium concentrations below 125 mmol(mEq)/1. Eighteen cases (41%) were iatrogenic, caused by diuretic treatment or postoperative administration of intravenous 5% dextrose, or both. Chest infection, a seldom-recognised and ill-understood cause of hyponatraemia, proved more common than carcinoma of the bronchus. Thirty-one patients had symptoms attributable to the hyponatraemia, but these were severe in only five cases. Analysis of blood and urine was of no value in distinguishing the different diagnostic groups in an emergency.

Diuretics↗
PubMed1978

Pituitary coma with continuing menstruation.

A case of pituitary coma with continuing menstruation is presented. This association is extremely rare, but a history of recent menstrual periods does not exclude advanced hypopituitarism from the differential diagnosis of severe hyponatraemia.

Coma↗
PubMed1977

The contribution of psychological features to the symptoms of treated hypertensive patients.

Twenty-seven symptoms of 859 treated hypertensive patients were evaluated using a self-administered questionnaire and correlated with the depression (DEP), free-floating anxiety (FFA), phobic anxiety (PHO), obsessionality (OBS) and extraversion (HYS) scores of the Middlesex Hospital Questionnaire. The psychological features were associated with 24 of the 27 symptoms, and the extent to which these measurements determined the presence of a symptom was calculated. DEP and FFA were correlated with most of the symptoms, PHO with weak limbs, blurred vision, slow walking pace, nocturia and a lessened interest in sex. HYS was positively associated with the frequency of sexual intercourse in men and negatively with complaints of dyspnoea, tingling in the limbs and a slow walking pace. OBS was only associated with diarrhoea.

Aged↗
PubMed1976

Spironolactone in essential hypertension: evidence against its effect through mineralocorticoid antagonism.

The effect of a six-week course of spironolactone 300 mg/day was examined in 25 unselected patients with essential hypertension. In the blood spironolactone produced a significant rise in urea and potassium concentrations and a fall in sodium and bicarbonate concentrations. In six patients blood pressure was normal at the end of the course, while in five patients there was almost no change. Studies of the effects of spironolactone on various indices usually affected by mineralocorticoids-namely, blood electrolytes, total body potassium, and rectal electrical properties-showed no differences between responding and non-responding patients. Mineralocorticoid excess therefore seems to be rarely responsible for essential hypertension and the influence of spironolactone cannot at present be fully explained.

Adult↗