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Biomedical subjects

B I Nesheim

Publications and source records attributed to B I Nesheim.

At least 19 recordsLinked to original sources

[Examination and treatment of gynecological bleeding disorders].

The investigation and treatment of gynaecological dysfunctional bleeding has remained largely unchanged since the problem was dealt with in a special issue of the Journal of the Norwegian Medical Association in 1976, in spite of the advent of modalities like endometrial cytology, hysteroscopy and vaginal ultrasonography, as well as knowledge about the relative lack of efficiency of dilatation and curettage in the investigation and treatment of the condition. We describe a modern programme for investigation and treatment of gynaecological dysfunctional bleeding. The programme relies on clinical assessment combined with medical therapy, with optional use of modern investigative modalities when indicated. In a strictly controlled outpatient programme the need for dilatation and curettage can be greatly reduced without jeopardizing the safety of the patient.

Adult

[Characterization of birth populations in 2 Norwegian counties, Akershus and Hordaland. A part of a study on smoking habits, alcohol drinking and drug utilization among pregnant women].

Norway participated in an international multicenter study on drug use, smoking, alcohol consumption, antenatal care, and complications in pregnancy. 482 women were interviewed at Akershus Central Hospital (near Oslo) and Haukeland hospital (in Bergen). Interviews were conducted during one of the first days after delivery using a standardized form. We found that 75% of the pregnancies were planned, while 7% were the result of contraceptive failure. 35% of the women smoked during pregnancy, compared with 43% before pregnancy. However, in relation to the early period of pregnancy the amount of tobacco consumed and the percentage of smokers increased slightly towards the end of pregnancy. Women who smoked were hospitalized during pregnancy more often than non-smokers. 91% of the women used some kind of medication during pregnancy including iron and vitamins.

Alcohol Drinking

[P pills and risk of cancer].

The article summarizes present knowledge on the relationship between use of oral contraceptives use and the risk of hormone dependent cancers. The authors conclude that, at present, this knowledge does not warrant a change in current prescription practice.

Adult

Comparison of postpartum pain treatments using a sequential trial design. I. Paracetamol versus placebo.

A new sequential test has been used to compare the effect of paracetamol and placebo on uterine cramping. Paracetamol was significantly superior to placebo at the 5% level. 75 patients were included in the trial, whereas in a fixed sample study 90 patients would have been required to obtain the same significance level and power. The magnitude of the difference in treatment effect was estimated following the sequential test. In addition to the effect on uterine pain, which was the primary variable, the effect on episiotomy pain was also estimated. Paracetamol was also superior to placebo against the episiotomy pain.

Acetaminophen

Comparison of postpartum pain treatments using a sequential trial design: II. Naproxen versus paracetamol.

The efficacy of naproxen and paracetamol in relieving uterine cramps has been compared in a sequential trial. The treatments did not differ significantly in a two-sided test in 56 patients. A corresponding fixed sample test would have required 140 patients to obtain the same significance level and power. In addition to uterine pain, the effect on episiotomy pain was also estimated at the termination of the trial. Again, there seemed to be no difference between naproxen and paracetamol.

Acetaminophen

Monochorionic monoamniotic twins--the most precarious of twin pregnancies.

Monochorionic monoamniotic twins have a high perinatal mortality rate. Death usually occurs before 24 weeks' gestation, mainly because of cord entanglement, prematurity, congenital anomalies or twin-to-twin transfusion. These possibilities should be taken into account when twin pregnancies are detected at the ultrasound screening between 17 and 20 weeks' pregnancy. We report here a case where monochorionic monoamniotic twins were born at 34 weeks, with massive cord entanglement and we describe the antenatal care at our clinic.

Adult

Neurobehavioral response of infants after paracervical block during labour.

30 parturient women were randomized into a group receiving paracervical block (PCB) and a control group. The infants were tested by a neurobehavioral examination immediately after birth, after 3 hours and 3 days. The examiner was unaware of the obstetrical management of the patients. No clinically significant differences could be detected between the two groups. Arterial and venous pO2, pCO2 and pH from the umbilical cord showed no differences between the groups.

Adolescent

Effect of acetylsalicylic acid, paracetamol and placebo on pain and blood loss in dysmenorrheic women.

The analgesic effect of paracetamol, acetyl-salicylic acid, and placebo on dysmenorrhea were compared in a double-blind cross-over study of 30 women. There was a moderate placebo effect, but no significant difference was found between the three treatments. Blood loss was also measured and it did not vary, with the type of drug ingested. It is concluded that paracetamol and acetylsalicylic acid in the doses used (0.5 g x 4 for 3 days) were not effective against heavy dysmenorrhea, and that none of the drugs influenced the amount of blood lost.

Acetaminophen

Effect of acetylsalicylic acid, paracetamol, and placebo on pain and blood loss in dysmenorrhoeic women.

The analgesic effect of paracetamol, acetylsalicylic acid, and placebo on dysmenorrhoea were compared in a double-blind crossover study of 30 women. There was a moderate placebo effect, but no significant difference was found between the three treatments. Blood loss was also measured and it did not vary with the type of drug ingested. It is concluded that paracetamol and acetylsalicylic acid in the doses used (0.5 g X 4 for 3 days) were not effective against heavy dysmenorrhoea, and that none of the drugs influenced the amount of blood lost.

Acetaminophen

[Analgetics].

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Abnormalities, Drug-Induced