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Biomedical subjects

B I Rose

Publications and source records attributed to B I Rose.

At least 19 recordsLinked to original sources
PubMed1996

Ovarian drilling in infertile women with polycystic ovary syndrome.

Ovarian drilling is a laparoscopic treatment for polycystic ovary syndrome. As with wedge resection, it is unclear why women with this syndrome ovulate after the procedure. Studies describing the clinical response of over 600 patients to this treatment have appeared in the medical literature. Attention to detailed steps can guide experienced laparoscopic surgeons to apply this technique to appropriate patients who are experiencing infertility due to polycystic ovary disease.

Female↗
PubMed1996

Pregnancy in women under 35 with elevated early follicular phase follicle-stimulating hormone levels. A report of five cases.

BACKGROUND: An elevated follicle-stimulating hormone (FSH) level in the early follicular phase in women over age 40 has been associated with decreased potential for achieving pregnancy utilizing in vitro fertilization (IVF). Also, pregnancies achieved by such women commonly result in miscarriage. CASES: A private infertility practice surveyed all patient records in women under age 35 who were undergoing either IVF or controlled ovarian hyperstimulation. Five women were identified with persistent early follicular phase elevation of FSH. Patients were reviewed in terms of ovulatory function and other fertility characteristics. Four of these patients achieved pregnancy and delivered normal infants. CONCLUSION: Women under age 35 with elevated early follicular phase FSH levels constitute a heterogeneous group of patients. An elevated FSH level in such women may not have the same prognosis as it does in women over age 40.

Adult↗
PubMed1995

Laparoscopic management of polycystic ovarian disease.

Laparoscopic treatment of polycystic ovary syndrome has its roots in bilateral wedge resection. Although it is still unclear why surgery is effective in treating this syndrome, more than 600 cases of patients treated laparoscopically have been reported in the literature. Recent publications enhance our understanding of appropriate patient selection as well as the effectiveness of, and the complications associated with, this procedure.

Female↗
PubMed1994

Sperm motility, morphology, hyperactivation, and ionophore-induced acrosome reactions after overnight incubation with mycoplasmas.

OBJECTIVE: To evaluate the effect on the function on human sperm of overnight incubation with mycoplasma species. DESIGN: Prospective controlled in vitro study. SETTING: Community-based sperm bank and andrology laboratory. INTERVENTIONS: Percoll-separated sperm were incubated overnight with a low densities of Myco-plasma hominis and Ureaplasma urealyticum serotypes. MAIN OUTCOME MEASURES: Motility, midpiece and tail morphology, hyperactivation after overnight capacitation, and acrosome status after incubation with calcium ionophore. RESULTS: Overnight incubation with mycoplasma species resulted in small but highly statistically significant differences in motility, morphology, hyperactivation after overnight capacitation, and proportion acrosome reacted after incubation with calcium ionophore compared with controls. CONCLUSIONS: Incubation with mycoplasma species impairs sperm physiology. Identification and treatment of mycoplasma may augment a physiology-based infertility evaluation.

Acrosome↗
PubMed1991

Abdominal instillation of high-molecular-weight dextran or lactated Ringer's solution after laparoscopic surgery. A randomized comparison of the effect on weight change.

Abdominal fluid retention after the instillation of lactated Ringer's solution into the abdomen after operative laparoscopy was evaluated by comparing the serial weights of patients receiving lactated Ringer's after surgery to those of patients treated with the abdominal instillation of high-molecular-weight dextran and to those of negative controls. Twenty-four patients were randomized to receive either lactated Ringer's or high-molecular-weight dextran after operative laparoscopy. Patients undergoing only diagnostic laparoscopy served as negative controls. Patients receiving either lactated Ringer's or high-molecular-weight dextran had increased weights as compared to the negative controls for at least 36 hours (P less than .5), although the weight gain in the treatment groups did not differ statistically significantly. The weight gain remained significantly greater than in the negative controls on postoperative days 3 and 4 in patients treated with dextran. Since the "flotation" effect of dextran in preventing pelvic adhesions is likely to be most pronounced in the immediate postoperative period, the findings suggest the need for a reinterpretation of adhesion prevention studies in which the use of dextran was compared to that of lactated Ringer's solution or to saline as a negative control.

Dextrans↗
PubMed1988

Steroid profiles of follicular fluids from a patient with the empty follicle syndrome.

Steroid profiles of follicular fluid obtained from a patient during a cycle in which no oocytes were recovered in 12 follicular aspirates were compared with those of fluid obtained both from cycles of the same patient and from cycles of other patients when oocytes were recovered. Follicles aspirated in the cycle when no oocytes were recovered were shown to be neither atretic follicles, follicular cysts, nor prematurely luteinized follicles. The steroid profile of follicular fluid from the index cycle was characterized by a markedly increased estradiol-to-progesterone ratio and an increased androstenedione level. This, together with a comparison to the steroid profiles of fluid from follicles containing either fertilizable or nonfertilizable oocytes, suggests that the empty follicle syndrome may reflect a dysfunctional ovulation induction.

Androstenedione↗
PubMed1988

Multiple simultaneous predictors of gestational age. An application of Bayes' theorem.

Most obstetricians share the belief that an estimate of gestational age based on several clinical measures that agree with one another is more accurate than an estimate based on a single measurement. This paper presents a formal justification for this belief by applying Bayes' theorem to calculate the probability of a fetus being a certain gestational age by using information from several clinically established single predictors. The application of Bayes' theorem justifies the use of multiple measures of gestational age in individual ultrasound examinations and the use of serial ultrasound studies in the third trimester to more accurately estimate gestational age. The same technique could be applied to obstetric research studies that need to establish accurate gestational dating.

Age Determination by Skeleton↗
PubMed1988

The effect of human follicular fluid on endothelial cells: proliferation and DNA synthesis.

Human follicular fluid has been reported to cause angiogenesis. Although endothelial cell mitogenesis is a major component of the process of angiogenesis, the findings in the literature regarding the effects of human follicular fluid in in vitro endothelial cell growth assays are equivocal. In the present study, we examined the effect of human follicular fluid from preovulatory follicles on fetal bovine aortic endothelial cell proliferation. Human serum was used as a control since follicular fluid is largely a transudate of serum and could contain serum-derived endothelial cell mitogens. Neither human follicular fluid nor serum directly caused endothelial cell proliferation. However, follicular fluid, as well as serum, caused an increase in thymidine incorporation by endothelial cells, and resulted in an increased proportion of cells in the DNA synthesis and G2 phases of the cell cycle. Although follicular fluid was not directly mitogenic, it, in contrast to human serum, together with fetal bovine serum markedly enhanced endothelial cell proliferation beyond that caused by fetal bovine serum alone. These results suggest that a combination of factors, some of ovarian origin present in follicular fluid, and others from as yet unidentified sources, govern the mitogenic component of new blood vessel growth in the ovary.

Animals↗
PubMed1988

Major congenital anomalies in infants and glycosylated hemoglobin levels in insulin-requiring diabetic mothers.

Glycosylated hemoglobin levels were obtained in 133 diabetic pregnancies. Nongestational diabetic mothers delivered of infants with major congenital anomalies had significantly higher glycosylated hemoglobin levels than the remaining nongestational diabetic mothers (P less than .001). The higher a mother's glycosylated hemoglobin level, the higher her risk of having a severely affected infant was. The positive predictive value for a nongestational diabetic mother having an infant with severe congenital anomalies was 26% if the glycosylated hemoglobin level was greater than or equal to 11%, 40% if the level was greater than or equal to 12%, and 56% if the level greater than or equal to 13%. However, high glycosylated hemoglobin levels in insulin-requiring gestational diabetic mothers were not predictive of major congenital anomalies.

Congenital Abnormalities↗
PubMed1987

Ultrasound in obstetric decision making. How accurate are late ultrasound scans in gestational age and fetal weight assessment?

Gestational age determination based on obstetric dating criteria, early pregnancy ultrasound scans, Dubowitz examinations, and ultrasound scans performed shortly before delivery were reviewed for 69 preterm infants requiring neonatal intensive care. The last ultrasound scans underestimated gestational age by a median of 8 days, and by 2 weeks or more in 20 of the 69 cases, as opposed to best dating criteria. Ultrasonic fetal weight estimation was more accurate, but erred by more than 20% in 10% of cases. When obstetric decisions regarding preterm neonates must be made without prior information regarding gestational age, late ultrasound findings must be applied with extreme care.

Female↗
PubMed1987

Safety of Hyskon for routine gynecologic surgery. A case report.

Hyskon is widely used to prevent postoperative adhesions in infertility surgery. Occasionally its use leads to serious complications, some of which may have a delayed onset. An awareness of these complications will enable practitioners to lessen morbidity through appropriate patient selection for procedures involving Hyskon and through appropriate postoperative management.

Adult↗
PubMed1987

A simplified method for estimating fetal weight using ultrasound measurements.

A simplified method of estimating fetal weight was developed and tested on 366 ultrasound examinations performed close to delivery. Constructed by linear regression on the sum of the biparietal diameter (BPD), mean abdominal diameter, and femur length against the logarithm of birth weight, the model was compared to the Shepard-Warsof model, which uses BPD and abdominal circumference to estimate fetal weight. Models using the same simplified approach to estimate fetal weight using BPD with mean abdominal diameter, and femur length with mean abdominal diameter, were also developed. Fetal weight estimate tables for these models involve only one variable, making them easier to use.

Body Height↗
PubMed1987

Efficacy of Doppler echocardiography in the evaluation of aortic stenosis during pregnancy.

The recently developed technology of Doppler echocardiography was used to evaluate a pregnancy complicated by aortic stenosis. Given the lack of established norms for this test during pregnancy and the known cardiovascular changes during pregnancy, it is difficult to interpret this test. However, in the case presented, this test suggested the need for more conservative management, a plan that was justified postpartum.

Adult↗
PubMedDate not supplied

A conservative, low-cost superovulation regimen.

The protocol reported decreases the cost and inconvenience of inducing the growth of multiple ovulatory follicles in selected infertility patients. Safety was maintained by treating patients with relatively small amounts of exogenous gonadotropins and using patient response to slowly increase gonadotropin stimulation in subsequent cycles. The pregnancy rate was 26% per cycle. For couples with male factor infertility, it was 20% per cycle. This regimen may be especially suitable for the practitioner with only a few patients requiring this therapy who may not have the capacity to obtain daily estradiol levels.

Clomiphene↗