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Biomedical subjects

B Ia Reznik

Publications and source records attributed to B Ia Reznik.

At least 19 recordsLinked to original sources
PubMed1991

[The epidemiology of congenital defects in central nervous system development in children].

The prevalence and structure as well as risk factors for congenital developmental abnormalities (CDA) of the central nervous system (CNS) have been studied over recent 17 years among the newborn's population (217,000 births) and 7,845 dead children of varying age. The stage I work involved a retrospective analysis of the medical documentation up to broad-scale introduction of ultrasonography (US) of fetal abnormalities during pregnancy, the stage II work consisted in an analysis of the genetic monitoring after the introduction of US of the fetal states, comprising the pregnant, which approximated 98%. The significant risk factors for CDA of the CNS were the pregnancy rate (the IV and consequent ones), some types of pregnancy pathology (toxemia of the first half of pregnancy, infectious diseases) as well as prematurity, intrauterine hypotrophy, previous exposures of the mother and father of the future child to ionizing radiation. Over the recent years a stable tendency has been noted toward decrease of both the prevalence of CDA of the CNS among the newborn and dead children and of anencephalies and hydrocephalus, the developmental abnormalities most clearly diagnosed on US.

Brain↗
PubMed1991

[Experience with organizing regional genetic monitoring].

The necessity of conducting regional genetic monitoring (GM) is substantiated, an experience on its organization and the procedure of its carrying out with the help of computer technology is provided. The analysis of GM indicated that the incidence of developmental defects registered and listed is in the population limits. Proceeding from the example of anencephaly , the role of GM in the assessment of the effectiveness of comprehensive measures on prevention of birth of children with grave defects has been demonstrated.

Adult↗
PubMed1991

[Congenital developmental defects in children and environmental pollution].

In one of the southern regions of the Ukraine, analysis was made over the recent three years of the genetic monitoring data on the incidence and structure of congenital developmental abnormalities in the newborn as related to the status of environmental pollution (the content of dust, carbon black, carbon and nitrogen oxides, nitrogen and sulfur dioxides, hydrogen sulfide, formaldehyde, phenol, fluorine compounds in the atmospheric air; the content of toxic chemicals and pesticides in foods, soil, water and feeds) as well as to the radiation situation. In the region under study, areas with varying degree of environmental pollution were distinguished. That was mainly done in terms of the characteristics of the atmospheric air and (to a less degree) varying annual dose of external radiation on conversion to one inhabitant. Analysis of the genetic monitoring has demonstrated the prevalence of congenital abnormalities, in the genesis of which the mutation component was of paramount importance, to be significantly higher in an ecologically unsafe area. The data obtained can be used in the regional programs aimed at the improvement of the environment, a reduction of the influence of exogenous risk factors implicated in the formation of congenital developmental abnormalities in children.

Abnormalities, Drug-Induced↗
PubMed1990

[Phospholipid spectrum and the indicators of lipid peroxidation in the cerebrospinal fluid of newborn infants with perinatal lesions of the central nervous system].

A study was made of the phospholipid content and lipid peroxidation (LPO) in the cerebrospinal fluid of neonates in the early neonatal period. LPO was found to be activated in neonates with perinatal lesions of the CNS, correlating with the disease gravity. Appreciable changes in the phospholipid spectrum of the cerebrospinal fluid were revealed in all the components. The rise of the content of lysophosphatidyl choline turned out most significant. The interrelation between activation of LPO processes in the cerebrospinal fluid and changes in its phospholipid spectrum is under discussion. The characteristics under study may serve an additional diagnostic criterion for assessing the gravity of CNS lesion in neonates and should be taken into consideration in carrying out rational therapy in the acute disease period.

Humans↗
PubMed1990

[Problem of the prevalence of congenital malformations].

Birth-histories and files of 42,275 newborn infants, ambulatory outpatient files of 38,280 children aged between 6 days and 15 years, and also findings of 4,153 autopsies were studied. The study was conducted for the years 1979-87. It was found that on the whole the incidence of congenital malformations (CM) in children 0-15 years old was 2.83 percent, last three years this indicator being 3.27 percent. Among stillborns the proportion of CM was 10.2 percent, among newborns--13.8 per 1,000 and for the last three years it rose up to 18.2. The leading congenital defects in newborn infants, according to prevalence, were malformations of organs of movement, abdominal wall and gastrointestinal tract, malformations of cardiovascular system. The analysis of CM structure among dead children indicated that the most prevalent were malformations of the central nervous system and also two last above-mentioned groups. The majority of children with CM among the dead were children of the first year of life. Proceeding from these findings the principal ways of CM prevention were suggested and main risk groups with regard to birth defects were identified.

Adolescent↗
PubMed1989

[Analysis of the diagnostic significance of various immunologic indicators in children with primary glomerulonephritis].

A study was made of the immunogenetic parameters--the physicochemical properties of the circulating immune complexes (CIC) and their interrelation with HLA antigens--in 70 children aged 1 to 15 years with primary acquired glomerulonephritis (PGN). It has been demonstrated that the active period of PGN is characterized by high conceptration of the CIC of medium size (molecular mass) in children with HLA antigens. This characterizes the predisposition of the persons with the established phenotype to PGN as well as evidences that CIC play an undoubtful role in the pathogenesis of autosensitization in PGN.

Adolescent↗
PubMed1989

[Congenital developmental defects in children in the southern Ukraine].

The authors analyze clinical material and autopsy findings of fetuses and children dying at the age from 0 to 15 years during the last 15 years. For etiological evaluation of developmental congenital malformations the authors analyzed anamnesis, genealogy, dermatoglyphics, table materials, biochemical examination, karyotyping. The most frequent organs involved were the central nervous system, cardiovascular system, gastrointestinal tract and to a lesser degree--the genitourinary, osseous and respiratory systems. Congenital developmental malformations were registered in 10.2% of cases: in the prenatal period from 13.1 to 16.2% at different age. Among the children who died with developmental congenital malformations most were in the first year of their life.

Abnormalities, Multiple↗
PubMed1989

[Postmortem examination of congenital developmental defects in children and their role in thanatogenesis].

The authors examined case records and autopsy protocols of 6173 dead children aged 0-15 years made in the regional pediatric dissecting room over the past 15 years. The incidence of congenital malformations (CM) in the dead children was found to range from 22.5 to 29.2%. The central nervous and cardiovascular systems, and gastrointestinal tract proved to be the most affected organs, some increase in the incidence of CM observed in the last years occurring by higher affliction rates of just these systems. As for the proportion of multiple CM (MCM) in the total number of malformations, it accounts for 30.4%. The trends in the incidence of MCM have not substantially changed among dead children over the past 15 years. The contribution of CM as a cause of death among children has also remained unchanged. In 77.5% of the cases, CM is regarded as the major abnormality in the autopsy diagnosis. Children with CM predominantly die in neonatal (up to 29.2%), perinatal (up to 16.2%) periods, and, in general, in infancy (greater than 90%).

Abnormalities, Multiple↗
PubMed1983

[Evaluation of the effect of canned diet foods on the course of pyelonephritis in children].

The biochemical and immunological indicators were examined in 109 pyelonephritis children kept on the diet which included therapeutic preserves containing, apart from certain food ingredients, a complex of vitamins and tinctures of medicinal grasses. Therapeutic preserves were discovered to have a beneficial effect on the time course of the clinical symptoms of pyelonephritis, vitamin balance, lipid metabolism and immunity status. The results attest to advisability of applying therapeutic preserves as part of a complex of therapeutic measures to the management of children with pyelonephritis.

Adolescent↗