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Biomedical subjects

B Iyenger

Publications and source records attributed to B Iyenger.

9 recordsLinked to original sources
PubMed1993

Localization of a new enteric non-A, non-B [HEV] virus in target organ liver.

Thirteen Macaca mulatta monkeys were used for transmission of enteric non-A, non-B hepatitis virus (HEV) by the portal vein (PV) route. All these animals developed changes which are found in self-limiting acute viral hepatitis e.g. rise in liver enzymes, the presence of HEV specific viral particles in the stool and histological changes in the liver from 21 to 45 days after HEV inoculation. All the animals recovered completely as reflected by normalization of liver enzymes, and regenerative changes in the liver. The present report highlights the ultrastructural changes in the livers of these experimental monkeys. The histopathological changes included infiltration of lymphocytes and polymorphonucleocytes around the necrotic area, swelling of mitochondria, dilation of smooth endoplasmic reticulum (ER), and presence of 27-34 nm virus particles during the acute phase of the disease. In comparison, 9 control monkeys did not show any such histological changes.

Animals↗
PubMed1992

Effect of variations in temperature of injected saline on early development of chick embryo.

Development of chick embryo is sensitive to the incubation temperature and increase or decrease in incubation temperature produces defect in development but the effect of drug solution injected at variable temperatures on developing chick embryo has not been established so far. Fresh embryonated eggs were incubated and saline was administered at various temperatures after 17 hr of incubation. Embryos were harvested to see the effect of temperature variations of injected saline on neural tube formation. Normal neural tube development was seen only at 37 degrees C, hot or cold saline produced maldevelopment of neural tube. Thus it is concluded that any solution or drug which needs to be injected should ideally be used at 37 degrees C, as temperature lower or higher than that may vitiate the results.

Animals↗
PubMed1990

Animal transmission of enteric non-A, non-B hepatitis infection to Macaca mulatta by faeco-oral route.

M. mulatta monkeys were inoculated faeco-orally by enteric non-A, non-B virus to study the development of clinical, biochemical, histopathological and serological changes in the blood and liver. Pooled stool samples positive for putative non-A, non-B viral antigen by micro-ELISA and aggregated viral particles by immune electron microscopy, were administered in two M. mulatta monkeys. Biochemical, histopathological and serological changes were seen in the blood and liver and excretion of 27 nm virus like particles around 27 days of inoculation in the experimental monkey but not in the control animal.

Animals↗
PubMed1983

Dermatomic distributions of hypopigmented macular lesions of leprosy: neural dependence of melanocytic functions.

Dermatomic analysis of the distribution of the hypopigmented patches of leprosy has revealed a pattern wherein patches are most frequent in dermatomes of the brachial plexus, decrease gradually in frequency in succeeding spinal segments and increase again in dermatomes of the lumbar plexus. The predilection of hypopigmented patches for certain dermatomes may be a reflection of easy vulnerability of the neural pigmentary mechanism and/or a reflection of selective multiplication of M. leprae in nerves of certain dermatomes, even though the organisms might have been seeded all over the body by hematogenous spread. These preliminary observations are discussed.

Afferent Pathways↗
PubMed1983

Hypopigmentation in leprosy.

Hypopigmentation of macular leprosy lesions was not found to correlate with cellular infiltrate and AFB load in tissues. It is felt that hypopigmentation is in some way related to neural involvement.

Humans↗
PubMed1982

Comparative study of free omental, peritoneal, Dacron velour, and Marlex mesh reinforcement of large-bowel anastomosis: an experimental study.

The comparative role of free omental, peritoneal, Dacron velour, and Marlex mesh grafts in reinforcement of an extremely vulnerable experimental model of large-bowel anastomosis was studied in dogs. While both the omentum and peritoneum proved not to be effective in preventing anastomotic leakage, Dacron velour did considerably lower this incidence to within reasonable limits but led to formation of low-grade lymphoma at the reinforcement site in two animals. Only Marlex mesh was found to be highly effective in sealing the suture line, and it is anticipated that, with the usual technique of anastomosis, this sealing effect will be foolproof, thereby nullifying any risk of suture-line breakdown.

Animals↗
PubMedDate not supplied

Transmission of enteric non-A, non-B hepatitis virus in Macaca mulatta monkeys by intraportal route: subsequent passages of HEV virus.

Macaca mulatta monkeys have been used for the transmission of enteric non-A, non-B hepatitis (HEV) virus by intraportal route. Subsequent passages of HEV virus have been completed in these monkeys. In the first passage, 2 monkeys were inoculated by intra-portal route with 27-34 nm virus-like particles (VLP) obtained from known epidemics of HEV hepatitis in India, and biochemical and serological changes in the blood, histological changes in the liver and excretion of 27-34 nm VLP in the stool were studied. Results were compared with those of 4 negative control monkeys inoculated with stool extracts from healthy individuals. The second passage of 27-34 nm VLP was carried out on 2 monkeys using pools of stool suspension positive for 27-34 nm VLP from first passaged animals. Similarly, the third passage of 27-34 nm VLP was completed intraportally in another monkey. All monkeys developed acute hepatitis, as evidenced by transient elevation of aminotransferase, histopathological changes in the liver, development of antibodies aggregating 27-34 nm VLP and excretion of 27-34 nm VLP in stools. No control monkeys developed these features.

Animals↗