Incidental detection of impalpable testicular neoplasm by sonography.
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Adult↗
Biomedical subjects
B J Fernandes
Publications and source records attributed to B J Fernandes.
Diffuse lymphomatous polyposis of the gastrointestinal tract. A case report with immunohistochemical studies.
A case of diffuse lymphomatous polyposis of the gastrointestinal tract is reported. The patient presented with abdominal pain and weight loss and x-rays revealed multiple polyps involving the entire gastrointestinal tract. Biopsies confirmed the diagnosis of lymphomatous polyposis. The patient also had involvement of the bone marrow and supraclavicular lymph node. Immunologically this lymphoma was characterized as a monoclonal proliferation of B lymphocytes bearing immunoglobulin M, type kappa. Diffuse lymphomatous polyposis of the gastrointestinal tract appears to be a generalized malignancy of uncommitted B cells of Peyer's patches. The migratory properties of these cells may account for the tendency to dissemination of lymphomatous polyposis. Diffuse lymphomatous polyposis of the gastrointestinal tract is a distinct entity, separate from the diffuse gastrointestinal lymphoma known as Mediterranean-type lymphoma.
Aged↗
Adult T-cell leukemia-lymphoma with mediastinal involvement and an asymptomatic chronic phase.
A black, West Indian woman with adult T-cell leukemia-lymphoma (ATLL), hypercalcemia, peripheral and retroperitoneal lymphadenopathy, and serum antibodies to human T-lymphotropic virus (HTLV) was found to have massive mediastinal adenopathy, a feature not previously reported in patients with ATLL. In addition, she had had asymptomatic leukocytosis with marked lymphocytosis for at least 6 years before presenting with full-blown ATLL. These findings broaden the clinical picture of ATLL. Cell surface-marker studies and close follow-up are recommended for patients with apparent chronic lymphocytic leukemia, especially if they have pleomorphic lymphocytosis, are younger than usual or are from the Caribbean or Japan.
Adult↗
Nodular mediastinal amyloidosis.
A 67-year-old woman presented with supraclavicular lymphadenopathy, a large mediastinal mass, marrow plasmacytosis, and paraproteins, including free lambda light chains, in the serum and urine. Biopsies of the lesions demonstrated nodular amyloidosis, which was confirmed by ultrastructural and cytochemical analyses. Immunoperoxidase staining indicated that the amyloid was composed of lambda light chains. Nodular mediastinal amyloidosis is a rare manifestation of amyloidosis and appears to be a form of immunocytic amyloidosis.
Aged↗
Adult T-cell lymphoma. A case report with lymph node studies by monoclonal antibodies and ultrastructure.
A case of retrovirus-associated adult T-cell lymphoma studied by monoclonal markers and ultrastructure is reported. The patient, who was born in Jamaica and emigrated to Canada 9 years previously, had a 5-year history of asymptomatic lymphocytosis preceding the onset of rapidly progressive disease. The peripheral blood lymphocytes were predominantly pleomorphic small lymphocytes with a smaller population of transformed lymphocytes. The peripheral blood lymphocytes were typed immunologically as T-cells of helper/inducer phenotype. Immunological typing of the lymph node lymphocytes, performed on tissue sections, demonstrated a similar phenotype. Morphological study of the lymph node showed a diffuse lymphoma, encompassing a wide range of cell sizes, including giant cells. In view of the morphological heterogeneity of this condition, immunological and viral studies are recommended to confirm the diagnosis.
Adult↗
Lambda-light-chain nephropathy with Fanconi's syndrome.
Renal disease is a common complication of paraproteinemia, but light-chain nephropathy with resultant Fanconi's syndrome is unusual. In a 60-year-old man with Fanconi's syndrome, the underlying disease was a well-differentiated lymphocytic lymphoma, with two paraproteins and lambda-light-chain proteinuria. A renal biopsy specimen showed crystals in tubular cells, more prominent in proximal than distal tubules. Immunoperoxidase studies confirmed the lambda-light-chain content of the crystals. All previous cases studied by biopsy have involved kappa light chains. Light chains are thought to be toxic to the tubular epithelium, resulting in Fanconi's syndrome. Case reports of lymphoproliferative disorders associated with paraproteinemia and Fanconi's syndrome suggest a somewhat better prognosis with this clinical entity.
Bone Marrow↗
Mucus-producing medullary cell carcinoma of the thyroid gland.
A case of medullary carcinoma of the thyroid with the presence of mucus-secreting (goblet) cells was reported. Ultrastructurally, the tumor was composed of two types of cells, one with neurosecretory granules and the other with mucus granules. The secretion of calcitonin and mucus was demonstrated by histochemical methods. The presence of two cell populations in this tumor casts doubts on the "APUD" concept, which proposes a neuroectodermal origin for parafollicular (C) cells of the thyroid gland. The significance of this tumor with regard to the histogenesis of the cells involved, is discussed.
Adult↗
Radionuclide salivary scan imaging of a "functioning" malignant parotid tumor (mucous-producing papillary adenocarcinoma).
To date, all "functioning" or "hot" tumors on salivary gland scan have been benign - either the not uncommon Warthin's tumor or the rare oncocytoma. A positive salivary scan was obtained in a functioning malignant tumor of the parotid gland (a mucous-producing papillary adenocarcinoma). This occurrence has not previously been reported. The pathologic findings and the radionuclide images are demonstrated in this elderly female. It is presumed that the Technetium Tc99m pertechnetate has been concentrated in the tumor. The functioning epithelial cell, however, is not the benign oncocyte associated with other previously reported benign functioning tumors. Clinical discretion is therefore suggested in interpreting the significance of a functioning salivary gland tumor if encountered in an elderly female.
Adenocarcinoma, Papillary↗
The 4p- syndrome--an autopsy study.
The autopsy of an infant with the 4p- or Wolf-Hirschhorn syndrome revealed visceral abnormalities not previously described, i.e., agencies of the gallbladder and spleen. The parents' chromosomes were normal.
Chromosome Aberrations↗
Systemic infection with Alaria americana (Trematoda).
Alaria americana is a trematode, the adult of which is found in mammalian carnivores. The first case of disseminated human infection by the mesocercarial stage of this worm occurred in a 24-year-old man. The infection possibly was acquired by the eating of inadequately cooked frogs, which are intermediate hosts of the worm. The diagnosis was made during life by lung biopsy and confirmed at autopsy. The mesocercariae were present in the stomach wall, lymph nodes, liver, myocardium, pancreas and surrounding adipose tissue, spleen, kidney, lungs, brain and spinal cord. There was no host reaction to the parasites. Granulomas were present in the stomach wall, lymph nodes and liver, but the worms were not identified in them. Hypersensitivity vasculitis and a bleeding diathesis due to disseminated intravascular coagulation and a circulating anticoagulant caused his death 8 days after the onset of his illness.
Adult↗
Fatal human infection with mesocercariae of the trematode Alaria americana.
A fatal human infection with mesocercafiae of Alaria americana is described. Several thousand mesocercariae were estimated to be present in the peritoneal cavity, bronchial aspirate, brain, heart, kidney, liver, lungs, lymph nodes, pancreas, retroperitoneal adipose tissue, spinal cord, spleen, and stomach. Nine days from the onset of symptoms death resulted from asphyxiation due to extensive pulmonary hemorrhage probably caused by immun-mediated mechanisms. Circumstances suggest the victim probably ate inadequately cooked frog legs while hiking. Mesocercariae penetrated through the stomach wall and spread to the various organs both directly and via and circulatory system.
Adult↗
Myospherulosis (subcutaneous spherulocytisc disease).
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Adult↗
Improved engraftment of human tumours in SCID mice pretreated with radiation and anti-asialo GM1.
The effects of sublethal radiation (3 Gy) and anti-asialo GM1 (anti-ASGM1) on engraftment of human tumour cell lines and fresh tumour were evaluated in the severe combined immunodeficient (SCID) mouse. Four tumour cell lines (colonic adenocarcinoma LS174T, malignant melanoma MEWO, lung adenocarcinoma H125, chronic myelogenous leukemia K562) and a fresh colon cancer metastasis were injected subcutaneously, intraperitoneally or intravenously into SCID mice. Tumour volume and metastatic spread of implanted tumours were evaluated 3-8 weeks following inoculation. Pretreatment with radiation and anti-ASGM1 resulted in more rapid and extensive uptake of subcutaneous and intraperitoneal tumours. Tail vein injection into pretreated animals also resulted in a greater number of lung metastases of H125, MEWO and K562 cell lines. This study demonstrates that sublethal radiation and the elimination of murine NK cell activity with anti-ASGM1 improves tumour take rates. These findings should prove useful for investigations of human cancer immunotherapy using SCID mice engrafted with human lymphocytes and human tumours.
Animals↗