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B J Flehinger

Publications and source records attributed to B J Flehinger.

44 records · Page 3Linked to original sources
PubMed1972

Reducing the number of inferior treatments in clinical trials.

In clinical trials comparing two treatments, one would often like to control the probability of erroneous decision while minimizing not the total sample size but the number of patients given the inferior treatment. To do this obviously requires that one use a datadependent allocation rule for the two treatments rather than the conventional equal sample size scheme, whether fixed or sequential. We show here how this may be done in the case of deciding which of two normally distributed treatment effects has the greater mean, when the variances are assumed to be equal and known. Similar methods can be used under other hypotheses on the underlying probability distributions, and will provide a considerable increase in flexibility in the design of sequential clinical trials.

Clinical Trials as Topic↗
PubMed1969

Prevalence rates of uterine cervical carcinoma in situ for women using the diaphragm or contraceptive oral steroids.

Study of the prevalence rates of uterine cervical carcinoma in situ among women attending centres of Planned Parenthood of New York City, Inc., showed a small but statistically significant difference between the population choosing and using the diaphragm and the population choosing and using oral steroids for contraception. This can be attributed either to a decreased prevalence rate for women using the diaphragm or to an increased rate for women using oral steroids. The reason for the difference is not apparent from these data.

Adolescent↗