PubMed Health⌕ Search

Biomedical subjects

B J Masterson

Publications and source records attributed to B J Masterson.

At least 55 records · Page 3Linked to original sources
PubMed1985

Effects of thermal knives on wound healing.

Tissue response to injury caused by the electrosurgical scalpel, the hemostatic Shaw scalpel, the CO2 laser, and a standard steel scalpel have been compared. Subcutaneous incisions in pigs were evaluated histologically at 1, 4, 7, 14, and 22 days postincision. The least damage was produced by the standard steel scalpel at all time periods. Epithelial migration started on day 1 for the standard steel scalpel, on day 4 for the Shaw scalpel, and only on day 7 for the electrosurgical scalpel and laser knives. Lateral thermal necrotic zones were found for all three thermal knives. Tensile testing showed no significant differences in the early postincision tissue strength. By day 14 wounds made with the standard steel scalpel were stronger than those made with the Shaw and electrosurgical scalpel. These findings indicate that thermal injury delays the wound healing process.

Animals↗
PubMed1984

Methyl-CCNU, doxorubicin, and cis-diamminedichloroplatinum II in the management of recurrent and metastatic squamous carcinoma of the cervix.

Twenty-three patients with recurrent unresectable carcinoma of the cervix or distant metastasis at initial presentation were treated with methyl-CCNU (175 mg/m2) and doxorubicin (45 mg/m2) on day 1 and cis- diamminedichloroplatinum II (90 mg/m2) on day 22 of a 42-day treatment cycle. Twenty-two patients had squamous carcinoma and 1 had adenosquamous carcinoma. There were two complete responses (CR), five partial responses (PR) (greater than 50% tumor reduction, greater than 3-month duration), four patients with stable disease (less than 50% reduction, greater than 3-month duration), and 12 patients who had tumor progression. One CR has been maintained greater than 28 months, and the other greater than 8 months. Total CR and PR was 7 of 23 (30.4%). Three 23 responses occurred among 15 patients (20%) who had cancer primarily confined to the pelvis, while 4 of 8 patients (50%) with distant metastasis responded. During the initial 2 cycles of chemotherapy, 12 patients had myelosuppression, defined as a leukocytes less than 3000/mm3, granulocytes less than 1,000/mm3, or platelets less than 100,000/mm3. There were no treatment-related deaths.

Adult↗
PubMed1984

Platinum tissue concentrations following intra-arterial and intravenous cis-diamminedichloroplatinum II in New Zealand white rabbits.

Intra-arterial chemotherapy is supported by the rationale that regional infusion more than systemic administration can produce higher regional concentrations of cytotoxic drugs, thereby enhancing tumor kill. The hypothesis that intra-arterial infusion of cis-diamminedichloroplatinum II (DDP) enhances regional drug concentrations in tissue has not been studied. Therefore, 30 New Zealand white rabbits were treated with DDP. Fifteen animals were given DDP intravenously, and the other 15 received DDP by intra-arterial infusion into the terminal aorta. Necropsy was performed at 2, 6, 24, and 48 hours after infusion. Samples of tissue were analyzed for platinum content by flameless atomic absorption spectrophotometry. Uterine and ovarian platinum content was significantly greater after intra-arterial infusion than after intravenous infusion (P less than 0.001 and P less than 0.01, respectively). This substantiates the rationale that regional arterial infusion of DDP can achieve higher tissue platinum levels than the intravenous route, at least, in this animal model.

Animals↗
PubMed1984

Endoarterial pulmonary metastasis of malignant trophoblast associated with a term intrauterine pregnancy.

A previously healthy gravida 4, para 3, developed preclampsia and progressive dyspnea at the 37th gestational week and had bilateral pulmonary infiltrates on chest roentgenogram. She delivered a healthy, term, male infant with a normal appearing placenta. Postpartum, her respiratory status gradually worsened. A lung biopsy on the 20th postpartum day revealed intravascular trophoblasts, diffuse arteriolar thrombosis with pulmonary infarction, and subacute interstitial pneumonitis. Combination chemotherapy was instituted, but the patient died from respiratory insufficiency.

Adult↗
PubMed1984

Teaching laparoscopic sterilization.

First-year obstetrics-and-gynecology residents participated in the attempted sterilization of 411 women by either Falope Ring application (FRA) or bipolar electrocoagulation (LTC). Ability to complete the procedure, as well as intraoperative and immediate postoperative complication rates, was reviewed. Characteristics that predisposed women to complications were assessed. Complications were more common in 165 women who underwent sterilization with FRA than in those who had LTC. Two FRA patients (0.9%) required laparotomy because of bleeding. In addition, failure to establish a pneumoperitoneum led to a minilaparotomy in one case. Nineteen FRA women (11.5%) experienced minor complications. The only major complications with the use of LTC were the need for minilaparotomy in two women in whom a pneumoperitoneum could not be established. Minor complications occurred in 4 of 227 LTC cases (1.8%). Current or past patient characteristics did not influence outcome except in the cases of failure to establish a pneumoperitoneum; those women were significantly heavier than others in this series. Limited experience in the instruction of FRA may have contributed to the higher complication rate and to the greater number of problems complicating sterilization with FRA as compared to LTC.

Electrocoagulation↗
PubMed1983

Vaginal removal of the ovaries in association with vaginal hysterectomy.

Because of the paucity of reports documenting the risks of removing the ovaries through the vagina in association with vaginal hysterectomy, we undertook a review of our experience. Seventy-seven patients underwent vaginal oophorectomy in conjunction with other vaginal surgery. Twenty-eight of them had indications for removal of the ovaries. In 47 the ovaries were removed electively in the perimenopausal period. There was no significant increase in morbidity, and only one patient had major bleeding problems associated with the procedure.

Adult↗
PubMed1982

Management of condylomata acuminata with the carbon dioxide laser.

Ninety-four patients with condylomata acuminata of the lower genital tract and perianal region were treated with the carbon dioxide laser. Most were managed in the outpatient clinic, but 1 to 4 treatments were required depending upon extent of involvement. Of 90 patients, 75 (83.3%) were free of lesions on all follow-up examinations after initial treatment. Of 15 patients with recurrent lesions, 13 underwent a second laser treatment; 7 of these 13 have been subsequently free of condylomata. The overall success rate was 91%. The carbon dioxide laser provides an appealing method of management of condylomata acuminata because of its precision, rapid healing without scarring, and safety when used during pregnancy.

Adolescent↗