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Biomedical subjects

B J Masterson

Publications and source records attributed to B J Masterson.

83 records · Page 5Linked to original sources
PubMed1977

Giant uterine tumors: case report and review of the literature.

This is a case report of the management and surgical removal of a 65-lb uterine leiomyoma. This is the 56th reported case of a giant uterine tumor (25 lb or over) and the eighth such case reported in the last 35 years. The literature concerning these large tumors is reviewed, and a discussion of some of the important aspects of surgical management is presented.

Female↗
PubMedDate not supplied

Psychopharmacological treatment of delirium to restore mental capacity.

The authors report four patient cases of delirium in which medications were used to restore mental capacity when life-or-death treatment decisions were required. Although extensive literature on substituted judgment exists for delirium and depression compromising capacity to make competent decisions, the authors could locate no articles proposing aggressive delirium treatment for restoring patients' capacity to participate in their own care. Without surgical intervention, all four of the authors' patients faced imminent death. Without psychopharmacologic banishment of the patients' deliria, proxies would have been asked whether the patients should undergo potentially lifesaving but high-risk procedures. The patients would have lost the opportunity to express their wishes about heroic lifesaving medical measures.

Adult↗
PubMedDate not supplied

Surgical glove powders differentially modulate macrophage and lymphocyte-derived cytokines and eicosanoids production in vitro.

The objective of the present study was to determine the effect of surgical glove powders Biosorb, Keoflo, and CaCO(3) and Hydrocote (a powder-free film; Biogel) on cytokine and eicosanoid production by lipopolysaccharide/phorbol 12-myristate 13-acetate activated and unactivated HL60, U937, and RPMI 1788 cells, human monocyte/macrophage, and B lymphocyte cell lines. The unactivated cell culture-conditioned media contained a low level of interleukin-1alpha and -1beta, granulocyte macrophage colony stimulating factor, and tumor necrosis factor-alpha, which significantly increased after activation (p < 0.05). Exposure of unactivated cells to glove powders or Hydrocote (100 microg/ml) had little effect. However, these compounds appeared to have multiple inhibitory and stimulatory action on the production of these cytokines and eicosanoids in lipopolysaccharide/phorbol 12-myristate 13-acetate activated cells. For instance, granulocyte macrophage colony stimulating factor production was inhibited only in U937 cells by Keoflo and CaCO(3), whereas, tumor necrosis factor-alpha production was stimulated by Biosorb and Keoflo in HL-60, and CaCO(3) was found to be predominantly inhibitory on tumor necrosis factor-alpha production by these cells (p < 0.05). Total transforming growth factor-beta(1) production was stimulated by Biosorb and Hydrocote in U937 and HL-60 cells, respectively, but inhibited by Keoflo in U937 cells. However, Biosorb and Keoflo inhibited transforming growth factor-beta(1) production in both HL-60 and RPMI 1788 cells, without any effect on active transforming growth factor-beta(1). With regard to eicosanoids, Biosorb and Keoflo stimulated prostaglandin E(2) production by RPMI 1788 cells, whereas it was inhibited by all glove powders in HL-60 cells. Thromboxane B(2) production was stimulated by Keoflo and inhibited by CaCO(3) and Hydrocote in U937 cells. Finally, Leukotriene B(4) synthesis was found to become stimulated by Keoflo, CaCO(3), and Hydrocote in both HL60 and RPMI 1788 cells (p < 0.05). These data indicate that exposure of activated, but not unactivated, macrophages and lymphocyte to surgical glove powders and Hydrocote differentially effects the release of cytokines and eicosanoids by these cells. Considering that cytokines and eicosanoids play an important role in mediating the inflammatory and immune responses of wound healing, complications arising from glove powder exposure in vivo may involve mechanisms which alter the type and level of cytokine and eicosanoid production.

Journal Article↗
PubMedDate not supplied

Important points in managed care contracts.

Health care is increasingly managed through some contractual relationship. Such contracts vary and the contracting entities may be clinics, universities, health maintenance organizations, individual practitioner organizations, preferred provider organizations, corporate health plans, or other structures. It is estimated that within 10 years more than 70 percent of all health care will be provided through some type of managed care plan.

Contract Services↗