Biomedical subjects

B J Smits

Publications and source records attributed to B J Smits.

21 records · Page 2Linked to original sources

PubMedDate not supplied

Tyrosine turnover and protein synthesis during parenteral nutrition.

Three patients receiving total parenteral nutrition and one healthy subject receiving 5% glucose were infused for 10 hours with L-(U14C)tyrosine (1.5 microCi/hr). Two alternative assumptions were made regarding the fate of labeled carbon. Total and oxidative fluxes of tyrosine were calculated and these were used to determine rates of protein synthesis and breakdown. Patients showed positive net protein synthesis and oxidation of infused phenylalanine via tyrosine was shown not to be excessive.

Adult↗

PubMedDate not supplied

Leukocyte amino acid concentrations and their relationship to changes in plasma amino acids.

The leukocyte was selected as an accessible example of an actively metabolizing cell. Plasma and leukocyte amino acids (AA) were studied in a reference group and a group of 12 patients receiving total parenteral nutrition. Differences in the plasma AA were variable; some were higher and others lower in concentration in the infused group. Leukocyte AA concentrations were almost all higher in the infused group and the AA pattern was less altered than in plasma. An explanation of the changes is proposed which helps to clarify the relationship of plasma to cellular AA changes.

Amino Acids↗

PubMedDate not supplied

Plasma amino acid relationships during parenteral nutrition.

The plasma amino acidfs of 17 patients were studied before and during total parenteral nutrition (TPN). The amino acid (AA) pattern changed similarly for all patients. The AA concentration changes relative to preinfusion (PAER) were the most informative index of change. Two groups of AA were defined, the "branched chain" group (five amino acids) and the "hepatic" group (four amino acids) based on the correlation of PAER values. Comparison of PAER values with the ratio of AA intake to requirement indicated that the requirements of the sick patients were more similar to those of children than those of healthy adults.

Adult↗