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Biomedical subjects

B J van Herendael

Publications and source records attributed to B J van Herendael.

7 recordsLinked to original sources

Missed hysteroscopic detection of uterine carcinoma before endometrial resection: report of three cases.

Endometrial ablation or resection using hysteroscopy appears to be an effective treatment for menorrhagia resistant to medical therapy. Three patients with endometrial adenocarcinoma missed in the preoperative hysteroscopic and histological assessment and subjected to endometrial resection were collected in a multicenter study. One case was an early adenocarcinoma in the background of late proliferative endometrium in a 39-year-old woman. In the other two patients, ages 51 and 68, the adenocarcinoma developed in a polyp in a background of simple hyperplasia. Since hysteroscopy with endometrial biopsy might not be able to exclude the presence of an early intrauterine cancer, appropriate selection and accurate evaluation of patients are imperative before ablative surgery. Endometrial resection is preferred over endometrial laser ablation since it provides additional tissue for histologic examination.

Adenocarcinoma↗

Salpingoscopy is an important part of the infertility work-up.

STUDY OBJECTIVES: To assess the efficacy of salpingoscopy as a routine part of the infertility work-up by comparing laparoscopic findings with salpingoscopic findings, and to match the pregnancies achieved by the patients with findings obtained from the endoscopic evaluation. DESIGN: A retrospective study conducted between January 1990 and June 30, 1994. PATIENTS: One hundred twenty-four women undergoing infertility investigations. Two were suspected of having pelvic inflammatory disease, and one had an extrauterine pregnancy. SETTING: The Jan Palfijn General Hospital, Antwerp, Belgium. INTERVENTIONS: Video hysteroscopy, laparoscopy, and salpingoscopy were performed in every patient. Adhesiolysis was done in 46 and neosalpingostomy in 5. Salpingoscopy was performed on 188 fallopian tubes; 60 tubes (24.15%) could not be cannulated. Drilling of polycystic ovaries was done in eight patients, ovarian cystectomy in five, and myomectomy in one. Endometriosis lesions were treated in 38 women. MEASUREMENTS AND MAIN RESULTS: In 3 of 13 women who were diagnosed as having endometritis at hysteroscopy, salpingoscopy revealed severe lesions of the mucosal folds. Of the normal-looking tubes at laparoscopy, 25.8% had mucosal lesions. Of the abnormal looking tubes at laparoscopy, only 13.5% had normal mucosal folds. More than one-fourth (28.5%) of patients with endometriosis AFS I and II had mucosal lesions. The number of pregnancies achieved by these women correlated well with salpingoscopy except in those with class III lesions. CONCLUSION: This study confirms that tubes that look normal externally can have lesions of the endosalpinx. A maximum possibility of spontaneous pregnancy exists when the mucosal folds are normal. Class III lesions are compatible with fertility, although the probability is reduced. With severe mucosal lesions the chances of spontaneous pregnancy are very remote.

Adult↗

Instrumentation in hysteroscopy.

Good instruments and proper training enable one to make an accurate diagnosis and to operate successfully to correct an intrauterine abnormality. There are a limited number of instruments for diagnostic and operative hysteroscopy so that the gynecologist can quickly become acquainted with the most appropriate instruments for each clinical situation.

Endoscopes↗

Dating of the endometrium by microhysteroscopy.

In 173 consecutive cases of hysteroscopy, the microhysteroscope was brought into contact with the anterior part of the fundus uteri. The vascular pattern of the endometrium was then visualized and photographed. As the vascularization of the endometrium changes during the menstrual cycle, a dating of the endometrium was made based on the blood vessel pattern. An endometrial biopsy was taken in each case. Hysteroscopically we were able to define five different phases in the menstrual cycle: early proliferative, late proliferative, early secretory, late secretory, and premenstrual-menstrual phase. Histopathological examination confirmed the hysteroscopical diagnosis of the phases in 72, 69.7, 81.3, 53.8 and 70%, respectively.

Biopsy↗

Microanatomy of the human amniotic membranes. A light microscopic, transmission, and scanning electron microscopic study.

The human amnion was examined by means of light microscopy and scanning and transmission electron microscopy. The surface shows apart from microvilli a particular structure, called "blebs"; the intercellular junction is formed by desmosomes and a labyrinthine channel system, and at the base pedicels extend into the basement membrane. Cell shedding uncovers the basement membrane which seems to play a primordial role in preserving the intact amniotic cavity. These data underline the complex structure and the multiple role the amnion performs during gestation.

Amnion↗