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Biomedical subjects

B Janssen

Publications and source records attributed to B Janssen.

69 records · Page 4Linked to original sources
PubMed1987

Postural and motor asymmetries in newlyborns.

Twelve full-term newlyborns were examined during wakefulness for head turning and maintenance of head position within the first hour after birth. Ten showed a rightward bias on both these measures. This is the youngest age since birth at which such lateralized functions have been reported. In all infants head position was strongly related to the hand which contacted the mouth but not with contacts to other parts of the face. The reason for this difference is discussed and it is suggested that head position and hand-mouth contacting may form a lateralized synergism which biases the development of handedness.

Dominance, Cerebral↗
PubMed1986

[Value of vestibular neurectomy using the suprapetrosal approach in the treatment of Menière's disease].

Results of a suprapetrosal approach to vestibular neurectomy for the treatment of Meniere's disease in 60 patients between 1974 and 1984 (ORL clinic, Lille) demonstrated the benign nature of the operation and its efficacy (94.5% recovery rate). However, deafness is in no way altered, there is a relatively high risk of severe paralysis (3 patients--approximately 5%) and sequelae consist of typical facial hemispasm. The operation should be reserved for patients with severe Meniere's disease resistant to medical treatment. It is a difficult surgical procedure requiring a minutiose technique with identification of all guides described in the literature (blue line of superior semicircular canal and angle of Fisch, petrosal nerves, superior petrosal sinus). This operation is preferred to that of other approaches (retrolabyrinthic and retrosigmoid), since section of vestibular nerves in the pontocerebellar angle involves a greater theoretical vital risk (particularly by possible lesion of the vascular system of cerebellar arteries) and a risk of postoperative liquorrhea. Long-term risks are dominated by onset of bilateralization of the disease, an event which is however only moderately frequent (10% of patients).

Adult↗
PubMed1985

Purification of glycosylated apoprotein of tissue factor from human brain and inhibition of its procoagulant activity by a specific antibody.

The glycosylated component of tissue factor from human brain which totally retained on Concanavalin A-Sepharose was isolated by a four step procedure. The final product (6-7 S) exhibited an apparent molecular weight of approximately 45,000 under reducing conditions on SDS-gels corresponding with procoagulant activity of tissue factor after detergent removal. The optimal ratio of lipid to protein in reconstituting tissue factor activity was 500:1 (w/w) amounting to 240,000 U/mg. Peptidase activity was not detectable in the purified apoprotein or in the relipidated protein. The procoagulant activity of tissue factor was dependent on Factor VII but not on Factors VIII or IX, since in the absence of Factor VII clotting times were significantly prolonged. The activity of the reconstituted tissue factor could be reduced by a factor of 15 upon incubation with an antibody against the purified glycosylated apoprotein that was raised in the rabbit. The IgG-fraction of the antiserum neutralized the procoagulant activity of tissue factor in saline extracts from human brain and placenta in a time- and concentration-dependent manner indicating common antigenic determinants on the cofactor protein from both tissues.

Antibodies↗
PubMed1985

Two cases of interstitial deletion of the long arm of chromosome 1: del(1)(q21----q25) and del(1)(q41----q43).

Two unrelated children, one with a proximal interstitial deletion 1 (1(pter----q21: :q25----qter] and the other one with a distal interstitial deletion 1 (1(pter----q41: :q43----qter] are presented. The clinical features of the patient with a proximal deletion (q21-q25) correspond with those of eight earlier reported cases with a deletion 1q21/22/23----q25. The second patient with the distal interstitial deletion (q41-q43) is the first case published as far as we know. The clinical characteristics of the latter patient are compared with those of six cases with a terminal deletion 1q with at least one common band missing (1q42).

Abnormalities, Multiple↗
PubMed1985

[Otoneurosurgical treatment of tumors of the cerebellopontine angle. Apropos of a series of 93 cases].

Authors analyse their experience with the treatment of ninety-three cases of cerebello-pontine angle tumors. A trained team with an otologist and neurosurgeon can obtain best results, both functional and vital. The postero-trans-labyrinthine approach, as described by House and al is used ad the method of choice. Analysis of cases shows that big tumors are frequent and their therapy difficult even if the risk of mortality has been diminished.

Adolescent↗
PubMed1984

[Suprapetrosal approach to the anterosuperior surface of the petrous bone. Its importance for the treatment of rare lesions of the sphenoid bone, trigeminal nerve and internal carotid artery].

The anterior suprapetrosal approach provides access to the anterior part of the middle cerebral fossa and its various openings: small round, oval and large round foramina. Trephination of the floor of the cerebral fossa reveals the Eustachian tube, the intrapetrosal portion of the internal carotid artery, the pterygomaxillary fossa, and possibly a particularly markedly developed recess of the sphenoidal sinus. This new surgical approach can resolve certain rare but classical therapeutic problems, particularly of excision of tumors in this region: neurinomas of V developing anteriorly, meningioma.

Adolescent↗
PubMed1980

[About double drainage empyema treatment with bronchial fistula afer pneumonectomy (author's transl)].

We have resumed the files concerning the twenty patients treated these last eight years at Medico-Surgical center of Villiers Saint Denis for empyema with bronchial fistula after pneumonectomy, out of more than five hundred patients treatment for empyema of all origins. On that occasion, we explained the principals and the technique of double drainage which enabled us to cure 10 patients, the other ten died of a progressive resumption of cancer in the process of being treated. The direct treatment of fistula through endoscope has completed the action of pleural baths seven times. We also needed to resort to a complementary thorachoplasty seven times, in order to collapse a pouch already very reduced and disinfected by double draining, which had enabled us to block the fistula as well.

Adult↗
PubMedDate not supplied

Linkage analysis under locus heterogeneity: behaviour of the A-test in complex analyses.

The admixture test (A-test) is a popular method for the analysis of linkage data when locus heterogeneity is suspected. It can be applied on pairwise linkage data, multipoint data and even for the simultaneous analysis of data from multiple dispersed candidate regions. However, very little is known about the conditions for the use of the method under these divergent circumstances. By performing analytical evaluations, we demonstrate that the A-test is inconsistent if there is a relationship between the phenotype and the probability of being linked. Biased estimates of the recombination fraction (theta) and the proportion of linked families (alpha) may occur if the actual frequency of linked families is not identical among small and large families. We conclude that the A-test should be used with caution if the phenotype and the probability of developing the phenotype at a certain age cannot be shown to be equal for family members of linked and unlinked families. If dissimilarities in family size cannot be ruled out, the extent of bias should be considered and size specific alpha-values should be used in risk calculations.

Bias↗
PubMedDate not supplied

[Pain reduction by trans-articular atlanto-axial screw fixation in patients with chronic polyarthritis].

To reduce the risk of cervical myelopathy, 32 patients suffering from rheumatoid arthritis (RA) and atlanto-axial dislocation (AAD) underwent a suboccipital fusion. All patients were interviewed with a pain questionnaire after a mean postoperative follow-up of 21 months (range 2-46). The results indicate a significant postoperative pain reduction as assessed by a visual numeric analogue scale, as well as a reduction of analgesic consumption.

Adult↗
PubMedDate not supplied

[Is transcranial magnetic stimulation a helpful method in diagnosis of cervical myelopathy in patients with chronic polyarthritis?].

Fifty-seven patients with rheumatoid arthritis were examined clinically, radiologically, and by means of transcranial magnetic brain stimulation. With this method central motor conduction times of the corticospinal pathways can be measured. The aim of the study was to compare the different methods to detect a cervical myelopathy and to correlate them. In 90% of patients clinical signs of cervical myelopathy could be detected, although in two-thirds of these, the neurological deficit was minimal. Radiologically, over 50% of patients had an atlanto-axid dislocation (AAD) of more than 5 mm. The central motor latencies measured in the upper extremities were prolonged in 47% of cases. These results show the usefulness of transcranial magnetic brain stimulation as an additional noninvasive investigation for detecting compression of the cervical myelon. This is an additional useful criterion for determining the need for operative intervention.

Adult↗