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Biomedical subjects

B Jerneld

Publications and source records attributed to B Jerneld.

6 recordsLinked to original sources
PubMed1987

Proteinuria and blood glucose levels in a population with diabetic retinopathy.

In a population-based study of all insulin-treated diabetic patients on the Swedish island of Gotland, we compared the prevalence and severity of retinopathy with those of nephropathy as measured by proteinuria and serum creatinine levels. Of 365 diabetic patients, 66 (18%) had proteinuria. Of these 66, 39 (59%) had retinopathy. Proteinuria and serum creatinine correlated with increasing severity of retinopathy (P less than .001). Of 47 patients with proliferative retinopathy, 19 (40%) had proteinuria. Of 124 patients with retinopathy of other grades of severity, 20 (16%) had proteinuria. Visual acuity in the best eye was negatively correlated to proteinuria, which was present in 17 of 203 (8.4%) patients with a visual acuity of 20/20, compared with eight of 15 (53%) of those with a visual acuity of 20/200 or less. Blood glucose, determined two hours postprandially, was satisfactory (less than 10 mmol/l) in 162 patients (44%), unsatisfactory (10 to 14 mmol/l) in 89 (24%), and poorly regulated (greater than 14 mmol/l) in 114 (31%). Increasing mean blood glucose correlated to retinopathy (P less than .05).

Adolescent↗
PubMed1987

Visual acuity in a diabetic population.

In a population study of all insulin-treated diabetics and a random sample of those treated with oral antihyperglycaemic agents (OHA) in Gotland, Sweden, the visual acuity (VA) was determined. The prevalence rates of visual impairment (VA 0.1-0.2) and blindness (VA less than 0.1) in the insulin-treated group were 4.9 and 4.4%, respectively, and in OHA-treated diabetics 7.2 and 1.4%. The impairment and blindness were due to diabetic retinopathy (Rp) in 72% of the insulin-treated group, but only in 14% of the OHA-treated diabetics in whom cataract and age-related maculopathy were the predominant causes. Blindness was four times more frequent among insulin-treated females than males. On simple logistic regression test VA correlated with Rp, age at examination, age at onset of diabetes, duration of diabetes and sex. However, on multiple logistic regression analysis the only significant relationships with VA were in the insulin-treated group, a correlation with Rp and age; and in the OHA-treated group, a correlation with age only. Thus the higher frequency of blindness in insulin-treated women was explained by Rp and age. When standardizing for age, the fraction of blind patients was found to be significantly higher among the insulin-treated than in the OHA-treated diabetics (6.7 vs 1.4%).

Adult↗
PubMed1986

Relationship of duration and onset of diabetes to prevalence of diabetic retinopathy.

In a population study of all registered insulin-treated diabetic patients on the Swedish island of Gotland, the prevalence of diabetic retinopathy was determined with ophthalmoscopy, biomicroscopy, and color photography. Retinopathy was present in 173 of 368 patients (47%) and reached a prevalence of 100% after 30 years of diabetes. Proliferative retinopathy was found in 48 subjects (13%) and was more common in females (17%) than in males (9.4%) (P = .01). By simple logistic regression test, the prevalence of total and proliferative retinopathy was correlated with both duration and age at onset of diabetes (P less than .001). However, on multiple regression analysis only the relationship with duration was statistically significant (P less than .001); age at onset was not (P greater than .2). Age had an additional influence only on background retinopathy with hard exudates, which were more frequent in older subjects (P less than .01). Thus, age at onset of diabetes was not correlated with the prevalence of total or proliferative retinopathy.

Adolescent↗
PubMed1985

Prevalence of retinopathy in diabetes treated with oral antihyperglycaemic agents.

In a random sample of all diabetics treated with oral antihyperglycaemic agents on the island of Gotland, Sweden, retinopathy (Rp) was present in 24 (17%) of 140 patients examined. Eighteen patients had background Rp. 7 of these with exudative lesions. Four patients had pre-proliferative and 2 proliferative Rp. On multiple logistic regression analysis a significant correlation was found between Rp on the one hand and a longer duration and a younger age at onset of the diabetes, on the other. Rp was also significantly correlated to higher levels of glycosylated haemoglobin (HbA 1C). In an additional analysis restricted to the group with Rp, higher levels of HbA 1C were found in persons with Rp of a more severe degree. On a simple logistic regression analysis, a significant correlation (P less than 0.05) was found between a high body mass index and a low prevalence of Rp. on multiple regression analysis this correlation became weaker (P = 0.06).

Administration, Oral↗