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Biomedical subjects

B Justus

Publications and source records attributed to B Justus.

15 recordsLinked to original sources
PubMed1992

[Changes in the blood coagulation and fibrinolysis system in the course of normal pregnancy].

In the present study we investigated several factors of hemostasis and fibrinolysis during the normal pregnancy in 52 women. Whereas the Thrombin-Time did not show any change, the increase of the Hepato-Quick and the decrease of the Partial Thromboplastin-Time was significant. During pregnancy we observed a significant increase of the activity of fibrinogen, factor XII and prekallikrein as well as of the von-Willebrand-factor-antigen (VIIIR:Ag). The activity of factor II and X remained constantly. The increased activity of factors of hemostasis was accompanied by an increase of activity and concentration of antithrombin-III. In contrast to the activity of the hemostatic system we could not find any significant alteration of the fibrinolytic system. The cause must be searched in the observed increase of plasminogen-activator-inhibitor (PAI)--likly in combination with a decrease of the tissue-type plasminogen activator (t-PA). Our data indicate, that the highest risk for thrombosis already might exist in week 24 of pregnancy, because a distinct increase of hemostatic activity is combined with a nearly unchanged fibrinolytic activity.

Adult↗
PubMed1986

The effect of ovariectomy on lipoprotein metabolism during a period of one year.

In a follow-up study over one year the influence of sex hormones on lipoprotein metabolism in women after ovariectomy was investigated. During this relatively long period we could observe several changes of lipid and apolipoprotein levels in serum which may be caused by adaptive processes after withdrawal of sex hormones. The first phase of variation of lipids and apolipoproteins (2 weeks after ovariectomy) is strongly influenced by the operation trauma and characterized by a decrease of apo A-I, apo A-II, TC levels and an increase of the triglyceride level. The second phase (6-18 weeks after operation) shows an increase of the levels of apolipoprotein of HDL (apo A-I and apo A-II) and also apo C-II and apo C-III. The pattern in the third phase (one year after operation) differs from that of the two earlier phases and is similar to that in the natural postmenopausal state (elevation of apo B, TC, nonsignificant elevation of apo A-I and significant elevation of apo A-II). It seems that ovariectomy causes permanent changes of the LDL-level whereas the fluctuation of HDL is temporary. The late changes in the lipoprotein spectrum following ovariectomy in the reported direction may be important for the increase of ischemic heart disease observed by many investigators.

Adult↗
PubMed1986

[Behavior of prolactin, estradiol and ACTH in maternal blood in delivery by cesarean section].

The serum level of prolactin, estradiol (E2) and adrenocorticotropic hormones was determined pre-, intra- and postoperatively in 17 women with delivery by caesarean section. Three different anaesthetics were used before general anaesthesia and epidural anaesthesia. 9 women were able to nurse. Hormone levels of the nursing and non-nursing mothers were compared. An increased level of prolactin and significantly decreased of estradiol and adrenocorticotropic hormones was found in the nursing women postoperatively. The quotient of prolactin and adrenocorticotropic hormones is significant. It increased in nursing women in the childbed and remained almost constant with absent lactation. There were no differences according to methods of anaesthesia in hormones levels and secretion of milk.

Adrenocorticotropic Hormone↗
PubMed1985

[Results of treatment in the hyperprolactinemic anovulatory syndrome].

This is a report about the results of Parlodel and neurosurgical treatment of 30 patients with infertility and amenorrhea, in 18 cases combined with galactorrhea. There were 4 cases of non-ovulatory cycles with or without oligomenorrhea. 2 young girls had a primary amenorrhea. All patients wanted to have children. A pituitary tumor was diagnosed in 15 patients, it was microsurgically removed in 7 cases. 18 of 30 patients became pregnant after a drug treatment or combined neurosurgical and drug therapy.

Adenoma↗
PubMed1982

[Cytogenetic studies in primary amenorrhoea].

Thirty-nine patients with primary amenorrhoea were examined, with twelve of them exhibiting chromosomal aberrations. The classical chromosomal pattern of Turner's syndrome with 45,XO was exhibited by seven patients, while mosaicism was displayed in the karyogram of three. A typical iso-X-chromosome was established from a young girl without Turner's stigmata. Genuine gonadal dysgenesis without any chromosomal abnormality was recorded from four cases by means of ovarian biopsy through laparoscopy.

Adolescent↗
PubMed1978

[Hemorrhage in menopause and its histological correlation].

In an evaluation of 200 histological endometrial findings of female patients having postmenopausal haemorrhage malign changes were noticed in five per cent of the cases. This figure is much smaller than that which is usually mentioned in literature. However it corresponds in its proportion with the known clinical and anamestic risk factors.

Aged↗
PubMed1977

[Determination of heat stable alkaline phosphatase].

In this work the method for determination of serum heat-stable alkaline phosphatase (HSAP)--valuable as a placenta function test in pregnancy--is discussed. There are different informations about the optimal conditions for inactivating the nonplacental heat labile isoenzyms, and therefore the opinions on the clinical efficiency of HSAP vary in different studies. Sera of nonpregnant and pregnant females were heated at 40 degrees to 65 degrees C for 5 to 60 minutes. It is demonstrated, that in opposite to suggested opinions in several reports a temperature of 56 degrees C for 30 minutes is notsufficient to inactivate all nonplacental alkaline phosphatase isoenzymes. At 60 degrees C for 20 minutes and at 65 degrees C for 5 minutes in sera of pregnant and nonpregnant female controls we could find concordant results, so that these two conditions of inactivation are regarded as the best. We prefer a temperature of 60 degrees C and inactivate for 20 minutes, since these conditions are to reproduce more easy and allow a beter precision of the results, than 65 degrees C for 5 minutes.

Alkaline Phosphatase↗