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Biomedical subjects

B K Adadevoh

Publications and source records attributed to B K Adadevoh.

At least 19 recordsLinked to original sources
PubMed1982

Effect of chloroquine administration on the in vitro conjugation of oestradiol-17 beta by rat liver.

The conjugation of oestradiol-17 beta was studied in control and chloroquine-treated rats. Liver homogenates were incubated with [14C]oestradiol-17 beta and cofactors for 4 h at 37 degrees C and free radioactivity was extracted before and after hot acid hydrolysis. The extent of conjugation was estimated from the ratio of free radioactivity to free plus conjugated radioactivity. The method was authenticated by the negligibly low conjugation obtained for either heat-denatured homogenates or water blank. Each experiment was corrected for its own recovery. The effects of both single and multiple intramuscular injections of chloroquine phosphate to rats on the in vitro conjugation of oestradiol-17 beta were studied separately. It was observed that both procedures significantly potentiated conjugation.

Animals↗
PubMed1981

Plasma cortisol in Bos taurus and Bos indicus heifers in seasonal tropical climate.

Cortisol concentration in blood plasma was measured in Brown Swiss, Holstein-Friesian, and White Fulani heifers over two consecutive estrous cycles during each of the four quarters of the hot humid seasonal tropical climate of Ibadan, Southern Nigeria. Basal cortisol in plasma was low (between 1 and 10 ng/ml). Differences between breeds were not significant. Averages and increases with proestrus and estrus were higher in the wet season (March to August) than in the dry season (November to January). Packed cells volume was higher in the dry season than in the wet season. Seasonal changes in rhythmicity of the estrous cycle were not significant. The low cortisol in plasma probably reflects adaptation to the hot climate and a mechanism to prevent high metabolic heat.

Adrenal Cortex↗
PubMed1977

Contraception and haemoglobinopathies in Ibadan, Nigeria. An evaluation of the effect on anaemia.

The haemoglobin-genotype of women attending six family planning clinics in the city of Ibadan, Nigeria in a 16-month period was determined. Women with haemoglobinopathy S and C (Hb SS, SC and AC), in spite of the greater risks associated with pregnancy in them, were found to use the services of the family planning clinics less than others (Hb AA and AS) in the population. Women with Hb AA or Hb AS on different contraceptives had similar levels of erythrocyte packed cell volume except that reduced levels were observed in Hb AS acceptors on oral contraceptives not containing an iron supplement.

Adolescent↗
PubMed1976

Serum vitamin B12 levels in protein-malnourished children.

Serum vitamin B12 levels were assayed in 25 healthy and 35 protein-malnourished children aged 1-6 years. Serum proteins and haematocrit values of the children were also measured. Liver enlargement was estimated clinically. The mean serum vitamin B12 activity among protein-malnourished children was slightly higher than that for the control group. Serum vitamin B12 activity of the healthy Nigerian children was, however, high, and possible reasons for this are discussed in detail. There was some correlation between very high serum vitamin B12 levels among the protein-malnourished children and incidence of liver enlargement.

Blood Proteins↗
PubMed1976

Sulphonylurea and hypothyroidism in Nigerian diabetic subjects.

Thyroid function has been assessed using the T3-Uptake test in 98 nigerian diabetic and 50 non-diabetic control subjects. Whilst abnormal tests suggestive of thyroidal hypofunctional state were commoner in the group on chlorpropamide alone, and in combination with metformin, these were unrelated to the duration of treatment. In addition, none had clinical hypothyroidism.

Adolescent↗
PubMed1976

The effect of intra-uterine contraceptive devices on the oestrogen-induced incorporation of [3H-5]uridine into RNA by the rat uterus.

A length of copper or stainless steel wire or of silk thread suture was inserted as an intra-uterine device (IUD) for 3 days in the right uterine horn of ovariectomized virgin female rats. The left horn served as a control. The control rats were ovariectomized but had no IUD inserted. The in vitro incorporation of [3H-5]uridine into uterine RNA was significantly inhibited (P less than 0.005) in copper-bearing horns compared to control horns, while silk and steel devices had no inhibitory effect, thus indicating an effect of intra-uterine copper on oestradiol-induced uterine metabolism. The insertion of an intra-uterine device had no significant effect on uterine wet weight, DNA content or on the uptake of [3H-5]uridine into the nucleotide pool.

Animals↗
PubMed1976

Relationship of serum copper and zinc to human hypertension in Nigerians.

Serum copper and zinc levels were determined by atomic absorption spectroscopy in 48 hypertensive Nigerians and in 37 normotensive controls. Serum copper and total cholesterol levels were significantly increased in the hypertensive patients, but their serum zinc levels did not differ from those of the controls.

Adult↗
PubMed1976

Total serum calcium and phosphorus levels in women taking oral contraceptives.

Total serum calcium and inorganic phosphorus levels were determined in 185 Nigerian women attending the post partum Family Planning Clinic of University College Hospital, Ibadan, Nigeria. The concentrations of calcium and inorganic phosphorus were similar in 37 control subjects to those in 83 women who had been fitted with the Lippes loop. Serum calcium levels were significantly reduced (P < 0.01) in 25 women taking Ovral 28 and in 40 women taking Norlestrin-Fe in comparison with the control group. The serum inorganic phosphorus levels were significantly increased (P > 0.01) in the women taking oral contraceptives in comparison with the control group.

Adult↗
PubMed1976

Amniotic fluid bilirubin and creatinine concentrations in Nigerian pregnant women.

Amniotic fluid bilirubin and creatinine levels were determined in 143 pregnant patients of known maturity. The bilirubin values did not bear any significant relationship with the gestational age. The creatinine levels however, showed a rise as pregnancy progressed. Amiotic fluid mean creatinine values were below 1 mg/100 ml before 30 weeks and around 2 mg/100 ml close to term. Eighty per cent of all creatinine values at 37 weeks gestation and over were 1.6 mg/100 ml or more. The mean level of creatinine in amniotic fluid correlated with gestational age. This test can therefore be applied antenatally along with other clinical data to distinguish between the premature and mature infants.

Amniotic Fluid↗
PubMed1975

Total urinary oestrogen excretion during normal menstrual cycle and normal pregnancy in Nigerians.

Total oestrogens were measured during normal menstrual cycles and during pregnancy in healthy Nigerian women. During the menstrual cycle, maximum excretion was consistently observed in the luteal phase in contrast to findings in European and American populations. During pregnancy, oestrogen excretion was similar to that reported amongst Europeans only in early pregnancy; oestrogen excretion did not show the usual rapid rise in late pregnancy.

Adolescent↗
PubMed1975

Serum calcium, phosphorus and magnesium levels in pregnant and non-pregnant Nigerians.

Serum calcium, inorganic phosphorus and magnesium were determined in 282 Nigerian women comprising 213 pregnant women, 37 non-pregnant controls, and 32 postpartum women. There was very little change in the serum calcium levels throughout pregnancy; the slight reduction which occurred during the 8th and 9th months was not statistically significant. There was a significant reduction in the serum concentrations of inorganic phosphorus and magnesium during the 8th and 9th months of gestation; the levels of both minerals rose to non-pregnant levels at term.

Calcium↗