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Biomedical subjects

B K Fisher

Publications and source records attributed to B K Fisher.

At least 37 records · Page 2Linked to original sources
PubMed1985

Immunohistochemical staining of macrophages in the skin lesions of leprosy: the role of antibody to mycobacteria in human serum and various polyclonal immune rabbit antisera.

Immunohistochemical staining of tuberculoid and lepromatous leprosy skin lesions was performed using various rabbit antisera. Macrophages in both stained with serum containing antibodies against lysozyme and alpha-1-antitrypsin, while macrophages in lepromatous leprosy also reacted with other antibodies. An immunoglobulin fraction of positive serum stained following pepsin digestion, indicating that reactivity was not Fc dependent. Positive serum contained antibody against Mycobacterium butyricum, which caused macrophage staining, since affinity-purified antibody did not stain and absorption with M. butyricum removed staining. Staining was also produced by serum of subjects with leprosy or a positive tuberculin test. By immunoblotting, the anti-mycobacterial antibody was directed against surface components of M. butyricum of molecular weights 20 000-70 000. Electron microscopy showed M. leprae in phagolysosomes of macrophages, while immunoelectron microscopy demonstrated labelling along bacterial cell membranes. Therefore, macrophages in lepromatous leprosy skin lesions stain because they contain M. leprae, which reacts with antibody to either M. leprae, M. tuberculosis or atypical mycobacteria in human serum and with antibody to M. butyricum in serum from rabbits immunized with various antigens and Freund's complete adjuvant. These results indicate that immunohistochemical studies on leprosy are misleading if performed using intact polyclonal immune sera rather than affinity purified or monoclonal antibodies.

Antibodies, Bacterial↗
PubMed1985

Ganglion of the ankle.

Ganglia rarely occur on the ankle. We report a case of a ganglion on the medial malleolus, originating from the sheaths of the flexor digitorum longus and tibialis posterior tendons, which posed a diagnostic dilemma for the patient's family physician, for her dermatologist, and for the orthopedic surgeon seen in consultation. Ganglia should be considered in the differential diagnosis of all periarticular cystic lesions.

Ankle↗
PubMed1984

Woringer-Kolopp disease. A form of mycosis fungoides.

Woringer-Kolopp disease usually manifests as a solitary cutaneous patch or several patches confined to a single body region. While most cases have a good prognosis, there have been rare reports of cases with an aggressive course and a fatal outcome. The authors present two women who are alive with this condition, which, they believe is a variant of mycosis fungoides.

Adult↗
PubMed1984

Oral leukoedema.

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Adult↗
PubMed1981

Multiple linear spiradenomas.

A case of eccrine spiradenoma (ESA) is described in a 35-year-old man. During an 18-year period, the original number of tumors grew in size and fused into large groups. Surgical excision of all tumors was performed successfully. The unusual features of the case were a linear distribution and giant multifocal tumors. The histology of the tumors and their appearance at the beginning and 18 years later is described.

Adenoma, Sweat Gland↗
PubMed1981

Leishmaniasis recidivans treated with sodium stibogluconate.

Two cases of leishmaniasis recidivans of twenty years' duration were treated intravenously with sodium stibogluconate (Pentostam) with good results. Before treatment, histologic examination of a biopsy specimen revealed many Leishman-Donovan (LD) bodies. After treatment, repeated biopsies done in one of the cases revealed only scar tissue. We recommended treatment with sodium stibogluconate in cases of leishmaniasis recidivans, although an ideal treatment for this condition still does not exist.

Adult↗
PubMed1980

Favus.

Favus has become a rarly found chronic fungal infection mainly caused by Trichophyton schoenleini and occasionally by Trichophyton violaceum or Microsporum gypseum. It can still be found in areas where the population suffers from poor hygiene and malnutrition. Cases are seen in the Mediterranean basin, the Middle East, Asia, Poland, Russia, France, and the Balkans. Isolated cases have also been reported from South Africa, Mexico, Central America, and Canada. Cases are encountered occasionally in the United States, almost exclusively in immigrants.

Adolescent↗
PubMed1980

Multiple clear cell acanthomas.

Clear cell acanthoma is usually a solitary benign epidermal tumor. Multiple lesions are rarely encountered, and only 11 such cases could be found in the literature. In all cases, the lesions were limited to the lower extremities. A few of the patients have had ichthyosis and/or varicose veins. We describe a 12th patient who, in addition to leg lesions, had lesions on the trunk and associated dry skin.

Aged↗
PubMed1979

Fucosidosis.

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Angiokeratoma↗
PubMed1978

Squamous cell carcinoma arising in a meningomyelocele.

Squamous cell carcinoma developed in the meningomyelocele of a 25-year-old man. This is the third such case reported. The possibility of malignant disease arising in this congenital defect must be taken into account when treatment is being considered.

Adult↗
PubMed1978

Mutilating basal cell epithelioma.

A 49-year-old man was found to have a rare, mutilating basal cell epithelioma of the face. Conventional early therapy with surgery and radiotherapy did not halt the progress of the disease in a hospital environment. The patient died 12 years later.

Basal Cell Carcinoma↗
PubMed1978

Microsporum canis infection: first epidemic in Israel.

We report here on the first epidemic of Microsporum canis infection in Israel. All 78 cases were diagnosed in the port city of Eilat between August, 1975 and May 1976. The epidemic has apparently been controlled with Griseofulvin therapy and public health measures.

Adolescent↗
PubMed1977

Diazepam-induced coma with bullae and eccrine sweat gland necrosis.

Bullous skin lesions that indicate sweat gland necrosis have been known to occur in drug-induced coma resulting from barbiturates and in carbon monoxide poisoning. To our knowledge, this is the first cases in which diazepam is implicated in causing bullous lesions over pressure points, and the first case showing on biopsy specimen eccrine sweat gland and sweat duct necrosis. Penile and oral lesions are being described here for the first time to our knowledge. The following mechanisms could be responsible for the skin lesions: hypoxia, local pressure, hyperthermia with excessive sweating, and a specific toxic effect on the eccrine gland. With the increasing use of the benzodiazepines, such lesions could be seen more frequently in the future.

Adult↗
PubMed1977

Basal cell epithelioma of the vulva.

A case of basal cell epithelioma of the vulva is reported. Basal cell epitheliomata of the vulva are less rare than commonly thought. They are easily misdiagnosed and the proper treatment may thus be delayed.

Basal Cell Carcinoma↗