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Biomedical subjects

B K Poddubnyĭ

Publications and source records attributed to B K Poddubnyĭ.

At least 19 recordsLinked to original sources
PubMed1996

[Autofluorescence diagnosis of malignant tumors of the head and neck].

A new method for diagnosing human malignant tumors is dealt with, which is based on fluorescence of malignant neoplasms and their adjacent normal tissue. To measure the fluorescence spectra, a fiber optic system and a multi-channel optic spectral analyser have been designed. While analysing the resultant spectra, a greater fluorescence excess was observed in the red wave band in the tumors than in normal tissue. Further investigations are required in order to use the method in question in clinical diagnosis.

Biopsy↗
PubMed1991

[Endoscopic studies in lymphosarcoma in children].

The value of various endoscopic methods in diagnosing lymphosarcoma was assessed in 149 suspects aged 3-14 years. Fiberscopy of the upper digestive tract was performed in 130 children of whom 43 revealed lymphosarcoma in Waldeyer's ring whereas in 87 lymphoid hyperplasia was detected. Laparoscopy was carried out in 17 children, esophagogastroduodenoscopy--2 and colonoscopy--in one case Endoscopic methods proved to be of high diagnostic value, easily available and safe for examination of children suspected for lymphosarcoma.

Adolescent↗
PubMed1990

[Diagnosis of primary tumors of the trachea].

The paper presents 10-year results of endoscopic examinations which have been performed of late in the Endoscopy Department of the All-Union Cancer Research Center. Altogether 36 patients with primary tracheal tumors (PTTs) were evaluated. The study of PTTs endoscopic pattern suggested the conclusion on feasibility of visual differential diagnosis of various tumors and assessment of the tumor spread along the bronchial tree.

Adult↗
PubMed1990

[Endoscopic laser recanalization in the chemo- and radiotherapy of stenosing cancer of the esophagus].

The authors analyze the results of endoscopic laser recanalization in 11 patients with stenosing esophageal carcinoma, whose mean age is 61 years. The tumor was located in the upper thoracic portion of the esophagus in 3 patients, in the middle thoracic portion in 6, and in the lower thoracic portion in 2 patients. The diagnosis of carcinoma was morphologically verified. The length of the esophagus involvement was estimated by x-ray data and varied from 5 to 12 cm and longer. Endophytic form predominated--it was diagnosed in 5 patients. The technique of endoscopic laser recanalization by means of Raduga-1 unit with neodymium alumo-yttrium garnet laser as the source of irradiation is described. The method was specified with consideration for the type of tumor growth. The patients were kept on parenteral nutrition during the treatment session. Three-five days after endoscopic laser destruction long-distance open-field gamma-beam therapy was administered to 10 patients and polychemotherapy to 9 of these. After laser destruction dilatation of the stenosed portion of the esophagus from 0.2-0.6 to 1.0-2.0 cm was recorded in 10 patients. Complete regression of the tumor resultant from laser destruction and chemoradiotherapy was achieved in 5 patients, partial regression in the rest 5. The patients were followed up for 5-12 months. No recurrences were recorded in patients with complete regression of the tumor; the process progressed in 3 cases with partial regression. Studies on improvement of recanalization technique, specification of indications for and contraindications against this treatment modality are in progress.

Aged↗
PubMed1990

[Diagnostic and therapeutic tactics in gastric polyps].

During examination and dynamic endoscopic follow-up of 151 patients suffering from polyps of the stomach of various histological structure with various degree of epithelial dysplasia or without it, different types of treatment were undertaken in 61 patients. The results of the treatment are analysed, the efficacy of different methods of biopsy of polypoid structures and alternative methods of treatment of patients with benign and malignant polyps are evaluated, and the recognition of endoscopic polypectomy as a diagnostic and therapeutic intervention is substantiated.

Diagnosis, Differential↗
PubMed1989

[Laparoscopic diagnosis of neoplastic diseases in ambulatory patients].

The article deals with the results of the first experience in using laparoscopy for establishing the diagnosis of neoplastic diseases of the abdominal organs in 32 patients in an out-patient clinic. The contraindications were determined and some organizational measures in conducting laparoscopy in this group of patients were mapped out. A method is suggested for closing the operative wound after laparoscopy with sutures applied through all layer under laparoscopic control. The authors consider strict selection of patients for laparoscopy in out-patient clinics to be expedient.

Abdominal Neoplasms↗
PubMed1989

[Endoscopic evaluation of the therapeutic results in patients with small cell lung cancer].

The analysis of the data of 352 fiber bronchoscopies performed in 142 cases of small-cell lung cancer before, in the course and after chemotherapy or chemoradiation treatment makes a case for complex application of X-ray and endoscopic procedures since the data on diagnosis and response to treatment obtained under the separate use of either procedure agreed in 67.7% and 80.3% of cases only.

Bronchoscopy↗
PubMed1989

[Epithelial dysplasia and cancer of the stomach].

Relationships between chronic gastric diseases and gastric cancer are discussed. Mucosal epithelial dysplasia may be regarded as the most reliable sign of increased risk of gastric cancer. Endoscopy with biopsy is the principal method for the assessment of the dysplasia-cancer relationship. A retrospective study of histologic preparations and smear imprints from gastric biopsy specimens and operative samples, obtained from 292 patients with chronic gastritis, gastric ulcers, gastric polyps and polyposis, and conditions following gastric resection for nontumorous diseases and cancer (group 1) and 80 patients with verified gastric cancer (group 2), is reported. In both groups, there was mucosal dysplasia of varying markedness. Endoscopic monitoring revealed gastric cancer in 48 first-group patients. Gastric cancer, combined with dysplasia, was detected in 128 patients from both groups, its early stages, in 37 of those. Convincing evidence in favor of a relationship between dysplasia and cancer is presented.

Epithelium↗
PubMed1989

[The probability of malignant degeneration of stomach polyps].

A retrospective analysis of the endoscopic diagnostic data on 151 cases of gastric polyps of various histological structure was carried out. A relationship between the risk of malignant transformation of gastric polyps, on the one hand, and their histology, presence and degree of dysplasia, on the other, was established. Epithelial dysplasia, in pronounced degree included, was observed in 33.7% of patients with hyperplastic polyps and in all cases of gastric adenoma. Epithelial dysplasia of hyperplastic polyps was mild or moderate in most cases while that of adenomatous polyps was moderate or grave. Gastric cancer as a consequence of malignant transformation of polyps was detected in 15 (9.9%) patients (hyperplastic polyps--2; adenomatous polyps--13). No objective endoscopic criteria for establishing the risk of polyp transformation were developed. Grave epithelial dysplasia, i.e. precancerous lesions in the gastric mucosa, may be suggested as such criterion. Moderate or grave dysplasia of the polyp epithelium should be considered in forming the group at risk first and foremost.

Adenoma↗
PubMed1988

[The role of endoscopic study in the diagnosis of precancerous gastric pathology and identification of a risk group].

The results of endoscopic diagnosis and case follow-up of 686 patients with precancerous gastric conditions usually identified as a risk group (chronic gastritis, polyps, peptic ulcer, conditions following distal stomach resections) have shown that in patients with symptoms of epithelial dysplasia of gastric mucosa indices of cancer detectability significantly exceeded those in similar pathological conditions without symptoms of epithelial dysplasia. They were 22.0 +/- 2.5% and 2.5 +/- 0.8%, respectively; indices of stage I stomach cancer detectability were 9.9 +/- 1.8% and 0.2 +/- 0.2%, respectively. Patients with precancerous stomach diseases with moderate and severe epithelial dysplasia found in their gastric biopsies, should be attributed to a risk group, and these changes of gastric mucosa must be regarded as the main criterion for the identification of such a group.

Biopsy↗