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Biomedical subjects

B K Prasad

Publications and source records attributed to B K Prasad.

13 recordsLinked to original sources
PubMed1996

An investigation of the potential morphine sparing effect of midazolam.

The effect of a bolus and continuous infusion of midazolam on postoperative morphine consumption was assessed in a placebo-controlled, double-blind, randomly allocated trial of 50 patients undergoing elective abdominal hysterectomy. Patients in the trial group received a bolus dose of midazolam 5 mg.70 kg-1 at induction followed by an infusion at a rate of 1 mg.70 kg-1.h-1 over the next 48 h. Morphine consumption in the midazolam group was significantly lower in the first 12 h postoperatively (p < 0.02) but there was no significant difference between the two groups thereafter. Patients in the midazolam treated group had lower pain scores over the first 24 h. Also, a significantly greater number of patients in the midazolam group required no antiemetic medication over the 48 h study period (p < 0.05). Assessment of sedation revealed no significant difference between groups. We conclude that low dose midazolam has a significant, but short-lived, morphine sparing effect.

Adult↗
PubMed1985

Clinical experience with the use of two diphosphonates in the treatment of Paget's disease.

The effects of EHDP (20 mg/kd/day) and APD (4.5 mg/kg/day) given for three months to patients with severe symptomatic Paget's disease have been compared in an open trial of 17 patients. Both drugs were equally effective in producing a prompt reduction in pair scores, urine hydroxyproline, and serum alkaline phosphatase levels. The remission was maintained for a variable period after stopping treatment. Both drugs were well tolerated, and a one-month course of either drug was not effective. Comparison with published responses from previous studies indicates that EHDP given at this dose as a relatively short course is more effective than a lower dose for a longer period of time; the present study does not suggest that APD has significant advantages.

Aged↗
PubMed1977

Adrenergic activity of the oviduct of the domestic fowl.

The adrenergic activity of the domestic hen was investigated. Administration of noradrenaline to laying hens at dose levels of 3-5, 7-0, and 14-0 microng/kg produced an increase in the magnal pressure, and a simultaneous decrease in the uterine pressure. Similar doses given to ovariectomized hens caused an inhibition of activity in both segments. Strips of tissues from the vagina and the uterovaginal junction of laying hens were exposed in vitro to noradrenaline at concentrations of 1-5 x 10(-6) and 2.9 x 10(-6) M. The vaginal strips reacted with a sharp increase in tension, while the uterovaginal preparations showed a more gradual and prolonged response. It is suggested that the beta inhibitory activity of the uterus and the alpha excitatory activity of the rest of the oviduct are involved in the regulation of ovum transport.

Adrenergic Fibers↗
PubMed1976

Avian oviduct motility induced by prostaglandin E1.

Oviduct segments from infundibulum, magnum, uterus, utero-vaginal junction and vagina of actively laying hens at preoviposition time were tested for their contractile reaction to prostaglandin E1 by in vitro or in vivo methods. Maximum stimulatory response was observed from the muscular strips of the proximal oviduct segment (infundibulum) and a complete relaxation was recorded from the distal part (vagina) at molar concentrations of 1.4 X 10(-7), 3.4 X 10(-7) and 7.0 X 10(-7). The uterine strips reacted with a stimulatory response at higher concentrations (1.4 X 10(-6) and 2.8 X 10(-6) moles), but lacked any significant change at lower concentrations. The uterovaginal muscular strips showed a mild but prolonged inhibitory response, while the magnum responded with a significant increase in the luminal pressure when tested in vivo. It is concluded that PGE1 exerts a stimulatory effect on the uterus to initiate transport of the egg to subsequent segments (utero-vaginal junction and vagina), which relax under PGE1 influence and allow passage of the egg by pressure differences.

Animals↗
PubMedDate not supplied

Smoking women and their lung function tests.

Smoking amongst women has become significant as the number of smoking women is increasing gradually in this developing society. It affects the lungs to produce Chronic Obstructive Pulmonary Disease (COPD). Present study was conducted over 100 smoker's women and 100 non-smoker women in the age group of 30-40 Years. Three Lung Function Tests--FEVI, FVC and PEFR were employed to all smoking and non-smoking women. It was observed that all the above mentioned three parameters of lung function tests were reduced significantly among smoker women as compared to non-smoker women. These reduced parameters of lung function test among heavy smokers are suggestive of chronic obstructive lung diseases.

Adult↗
PubMedDate not supplied

A study of correlation between vitreous potassium level and post mortem interval.

Present study was undertaken to study the correlation of potassium level of vitreous humor with time since death. Vitreous was collected from 150 medicolegal autopsy cases between August 2000 to March 2001 in Bharatpur Hospital, Bharatpur, Chitwan, Nepal. There was a linear increase in vitreous potassium level with rise of postmortem interval. This indicates that rise in potassium levels after death has a strong correlation with the PMI.

Adult↗
PubMedDate not supplied

Sturge - Weber syndrome.

Sturge - Weber syndrome (SWS) is a rare disorder that occur with a frequency of approximately 1 per 50,0001. It isa neurocutaneous syndrome, characterized by a facial vascular birthmark and neurological abnormalities. The hallmark is intracranial vascular angioma, most often involving the occipital and posterior parietal lobes, but it can also affect the other cortical regions. An ipsilateral facial cutaneous vascular malformation (port wine nevus)usually affects the upper face. Other clinical findings associated with SWS are seizures, glaucoma, hemiparesis,mental retardation and delayed developmental milestones. This article reports a case of 8 years old boy who presented with weakness of right half of body since birth, mental retardation and delayed developmental milestones. Clinical examination revealed deep purple nevus on left lower face, and less power of left upper & lower limbs.X-ray skull showed calcification. C.T. Scan of brain revealed curvilinear calcification with focal atrophy.

Brain↗
PubMedDate not supplied

Post-mortem ocular changes: a study on autopsy cases in Bharatpur Hospital.

Post mortem eye changes are important evidences to assess post mortem interval. Present study was conducted at Bharatpur Hospital, Bharatpur over 150 autopsy cases during year 1999-2000. In 140 autopsy cases usual post mortem eye findings were observed, e.g. dull cornea, dilated and fixed pupil and soft eye. Fundus findings like cattle-truck appearance could be observed in 10 cases.

Cause of Death↗