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Biomedical subjects

B K Tripathi

Publications and source records attributed to B K Tripathi.

12 recordsLinked to original sources
PubMed1999

Diabetic gastroparesis.

Our understanding of gastric motility disorder--diabetic gastroparesis has advanced in the last ten to fifteen years, but the published data regarding pathogenesis are confusing and show conflicting results. The pathogenesis is sometimes linked with hyperglycemia, autonomic neuropathy, gastrointestinal hormone or myogenic mechanism. Antral hypomotility is often associated with hyperglycemia which is often accompanied by reduction in duodenal waves. Varying level of motilin, a gastrokinetic hormone has been reported. However none of the mechanism could explain the exact pathogenesis. The relationship of this mortality disorder with clinical symptoms is not always established, however nausea and vomiting lasting for days or weeks are the prominent symptoms. Other symptoms are post-prandial fullness, early satiety, bloating, belching, and vague abdominal discomfort. In a few cases, it may be the cause of poor nutrition, uncontrolled diabetes and recurrent ketoacidosis. Last one or two decades have seen some advancement in the investigational procedures like scintigraphy, radio-opaque markers, breath test, electrogastrography and MRI. Which can lead to a proper diagnosis. Such objective assessment is all the more important as nearly half of the patients do not have any symptom. Symptomatic improvement of gastroparetic patients should be the aim and in asymptomatic patients, treatment is often not recommended. Some dietary advice and prokinetic agents like metoclopramide, cisapride etc. are often prescribed but much needs to be further known as management is not always uniformly rewarding.

Diabetes Complications↗
PubMed1998

Experience in adult population in dengue outbreak in Delhi.

A dengue outbreak has recently hit the Indian capital. We studied the clinical profile of adult patients. Five hundred and sixty patients of dengue infection were admitted in a specially created ward according to the criteria laid down by WHO. Haematemesis (28.28%), epistaxis (26.78%) and malena (14.28%) were some of the common presentations. Similarly lymphadenopathy, especially cervical (30.89%), palatal rashes (26.96%) and hepatomegaly (23.75%) were the most commonly encountered findings on physical examination. Most of the cases were of dengue fever with haemorrhage and only 2.5% cases were classified under dengue haemorrhagic fever or dengue shock syndrome. The average hospital stay was 3.4 days but only 9.8 hours in the eleven patients who died, suggesting their late arrival in preterminal situation giving little time for resuscitation. Thrombocytopenia was not a feature and only 12.85% patients had platelet count less than 70,000/cmm. Most of the patients who were admitted with thrombocytopenia, showed normalization in their platelet counts in next few days. Serological examination demonstrated evidence of recent dengue infection in 41.17% patients. Few patients required blood or platelet concentrate transfusion. Eleven patients died, three due to DIC, one of intracranial haemorrhage and seven due to massive gastric haemorrhage. Rest of the patients recovered completely. Thus we can conclude that recent outbreak in Delhi was of dengue fever with haemorrhage and mortality was very low in patients who came early to the hospital.

Adolescent↗
PubMed1989

Ovarian and body weight responses of female redheaded bunting to ultra-short photoperiods: demonstration of circadian involvement.

Ultra-short photoperiods, of 3 h less than the threshold photoperiodic demand of female redheaded bunting, when used in variable time cycles (T cycles) cause ovarian growth and an increase in body weight depending upon the period of the cycle. The cycles of period 24 h or close to that (22 h and 26 h) were non-stimulatory whereas 18 h, 20 h, 28 h and 30 h were photo-stimulatory. These results indicate the presence of a circadian component within the bird which regulates their photoperiodic responses.

Animals↗
PubMed1987

Circadian control of photoperiodic responses in a female migratory bunting (Emberiza bruniceps).

The photoperiodic response of female redheaded bunting (Emberiza bruniceps) was investigated in photosensitive and photorefractory birds exposed to resonance lighting cycles. Ovarian growth was stimulated in resonance cycles where light was present during the predicted photoinducible phase. Photorefractoriness was dissipated by resonance cycles in which light did not fall at times corresponding to the photoinducible phase. It is concluded that photosensitive and photorefractory female redheaded bunting monitor the photoperiodic time by means of a circadian rhythm.

Animals↗
PubMed1983

Effects of exogenous prolactin on ovarian growth and fattening in the redheaded bunting, Emberiza bruniceps.

Subcutaneous daily injections of ovine prolactin (PRL) inhibit photoperiodic induction of gonads and fattening in the female redheaded bunting (Emberiza bruniceps). However, birds respond to the same photoperiod (15L:9D) after withdrawal of the exogenous PRL. Further, PRL injections given in late hours during the subjective days induce ovarian regression in the photostimulated females. The results suggest that the PRL has an inhibitory role on gonadal photoperiodic responses in redheaded buntings, and extend our understanding of the regulatory function of PRL in migratory birds.

Animals↗