A silent epidemic: coronary disease in women.
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Biomedical subjects
Publications and source records attributed to B K Valle.
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There is a continuum of clinical research in thrombolytic therapy that will eventually evolve into the most effective regimen to chemically open a thrombosed artery. Numerous previous clinical trials, a number of ongoing trials, and planned future trials are shown in a list of acronyms and their translations as a convenience for identifying the trials.
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The classification of myocardial infarction into transmural and subendocardial types has previously been based on the presence or absence of abnormal Q waves. The pathologic anatomy of necrosis in myocardial infarction does not necessarily correspond to these electrocardiographic criteria. It is therefore more appropriate to describe these infarcts as Q wave or non-Q wave myocardial infarctions. The importance of this classification is underscored by their clinical and pathologic differences and the tendency for more serious prognosis in the non-Q wave infarcts.
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There are changes in the elderly population that make them more vulnerable to disease, react differently to disease, and respond differently to drugs. The changes that occur in the geriatric population are (1) general physical deconditioning, (2) blunted physiologic response to change, (3) decreased resilience, and (4) degenerative changes common to aging. Appreciation of these changes helps in the diagnoses, management, and evaluation of prognosis in the senescent patient.
The circadian variation of major cardiovascular disorders, that is, TMI, AMI, SCD, and stroke, reflects an increased vulnerability to myocardial and cerebral ischemia and myocardial dysfunction in the early hours of the morning after awakening and rising. A comprehensive approach to treatment in patients with ischemic heart disease must take into consideration the chronobiology of the cardiovascular system and its relevance to the underlying disease process that affects the cardiovascular system.
Cardiac manifestations of AIDS probably occur more frequently than is appreciated--despite autopsy reports indicating that more than 50% of deceased AIDS patients had myocarditis. A high index of suspicion and the echocardiogram will help in revealing the true incidence of cardiac involvement in AIDS.