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Biomedical subjects

B Kaduk

Publications and source records attributed to B Kaduk.

At least 19 recordsLinked to original sources
PubMed1987

Morphology of the chronic toxicity of busulfan on the islets of Langerhans in the rat.

Male Wistar rats were fed Busulfan dissolved in fat milk at a daily dose of 0.35, 0.89, 1.20 mg/kg body weight for a period of four, eight and twelve weeks. Examination by light microscopy, including immunohistochemistry, and by electron microscopy revealed changes in the pancreatic islets which were dependent on dose and time. First, hyperaemia was demonstrated, then perivascular "inbleedings" were followed by organisation and islet fibrosis with centripetal reduction of the islet cells. This resulted in an almost complete loss of A-cells and a reduction in the number of B-cells. A morphological factor analysis suggested additional analogies to type I - diabetes mellitus, so that for the formal pathogenesis, islet haematoma and immunological events have to be discussed.

Animals↗
PubMed1986

Upper gastrointestinal bleeding as an unusual presentation of a duodenal carcinoid.

Carcinoid tumors may develop in any part of the gastrointestinal tract. They constitute 1.5% of all gastrointestinal tumors (1). The duodenum is one of the least common sites of this tumor, with a reported incidence varying between 0.2% and 8.9% (2, 3). We report on a case of a bleeding duodenal carcinoid in a patient who underwent bilateral nephrectomy for malignant hypertension.

Carcinoid Tumor↗
PubMed1986

Antacids and gastric mucosal protection.

Aluminum hydroxide-containing antacids have a protective effect on the stomach in that they prevent grossly visible mucosal necrosis and hemorrhages produced by noxious agents, such as aspirin or absolute ethanol. Histologically, this protective effect is mainly confined to the tissue located deep in the gastric mucosa, essentially comprising gastric glands, while the damage to the surface epithelium is not significantly lessened. Accordingly, integrity parameters of the superficial epithelial layer (potential difference, mucous secretion, cell desquamation) do not indicate a protective action of antacids against damage by necrotizing agents. By contrast, significantly diminished microbleeding rates do suggest that protection by antacids works at a deeper level within the mucosa. The protective action of antacids may be mediated, at least partly, by endogenous prostaglandins, which were found to be elevated in this context.

Animals↗
PubMed1986

Antacid protection of gastric mucosa.

Antacids containing aluminum hydroxide are protective for the stomach in that they prevent grossly visible mucosal necrosis and hemorrhages produced by noxious agents such as aspirin or absolute ethanol. Histologically, this protective effect is confined mainly to the tissue located deep in the gastric mucosa, essentially comprising gastric glands, while the damage to the surface epithelium is not significantly lessened. Accordingly, integrity parameters of the superficial epithelial layer (potential difference, mucus secretion, cell desquamation) do not indicate a protective action of antacids against damage by necrotizing agents. By contrast, significantly diminished microbleeding rates do suggest that protection by antacids works at a level deeper within the mucosa. The protective action of antacids may be mediated, at least in part, by endogenous prostaglandins, which were found to be elevated in this context.

Aluminum Hydroxide↗
PubMed1984

[Gold colitis].

Explore the source record for details and available documents.

Arthritis, Rheumatoid↗
PubMed1983

The immunocytochemical demonstration of human placental lactogenic hormone (hPL): a parameter for the functional capacity of the trophoblast.

Forty-two placentae from pregnancies of 36 to 42 weeks' gestation were examined: the maternal serum human placental lactogen (hPL) values of the mothers during the last week of gestation ranged between 3 and 12 micrograms/ml. hPL was demonstrated by the indirect immunofluorescence technique and was present in all placentae. A significant regional difference in hPL concentration was not found, but within individual sections focal differences in intensity were apparent. Of intensity group I (weakly positive) 92 per cent correlated with maternal serum hPL values of 3 to 6 micrograms/ml; 78 per cent of group II/III (very strongly positive) with values above 6 micrograms/ml. In the four-field Chi-square test the probability of error was at 5%. In 32 cases trophoblast islands (Islands of Ortmann) were present, of which 20 were hPL positive. Their degree of intensity corresponded to group I of the syncytiotrophoblast. Of the placentae showing hPL-positive Islands of Ortmann, 95 per cent correlated with maternal serum hPL values below 6 micrograms/ml whilst 70 per cent of the hPL-negative trophoblast islands correlated with serum values above 8 micrograms/ml. It is suggested that maternal serum hPL values are determined by the rate of synthesis of hPL by the placenta and not by the rate of secretion. The focal differences in intensity indicates that the serum level does not only depend on the absolute surface area of the trophoblast, but that there also exist qualitative and functional differences between different areas of the syncytiotrophoblast. Heterotopic hPL synthesis in the Islands of Ortmann is considered to be independent of hPL synthesis by the syncytiotrophoblast.

Female↗
PubMed1982

[Collagenous colitis (author's transl)].

Collagenous colitis, reported four times until now, is characterised histologically by subepithelial tape-like collagen deposits in the rectum and colon. On endoscopy the mucosa appears normal or slightly oedematous. The main symptom is chronic watery diarrhoea without admixture of blood. The cause of diarrhoea is thought to be defective absorption of electrolytes in the colon as a consequence of the pathological collagen deposition. Using endoscopic, histological and electron microscopic findings two further cases of so-called collagenous colitis could be detected. In one of the two female patients chronic watery diarrhoea occurred connected time-wise with the administration of an H2 receptor antagonist. In addition, a clearly increased pancreatic polypeptide (PP) in serum was demonstrated without proof of an endocrinologically active (pancreatic) tumour.

Colitis↗
PubMed1982

Gastric cytoprotection by antacids and papaverine in rats.

Prostaglandin E2 (PGE2) prevented hemorrhagic ulceration of rat stomach mucosa induced by various procedures when given orally at a non-antisecretory dose. This effect of PGE2 is called gastric cytoprotection. We used absolute ethanol, 0.6 N hydrochloric acid and 0.2 N sodium hydroxide as damaging agents. Ranitidine at an antisecretory dose did not exhibit any cytoprotective effect. However, the poorly absorbable antacids, magnesium hydroxide plus aluminium hydroxide and aluminium phosphate inhibited the development of hemorrhagic lesions significantly. A similar protective effect was seen after intragastric administration of papaverine, which is known to stimulate endogenous prostaglandin synthesis. However, the question as to whether or not stimulation of endogenous prostaglandin synthesis is the mode of action of the cytoprotective effect of papaverine and poorly absorbable antacids, cannot yet be answered.

Aluminum Compounds↗
PubMed1981

[Disease-specific renal failure in angioimmunoblastic lymphadenopathy - remission by high dose prednisolone. A case report (author's transl)].

The case of a 64 years old male with angioimmunoblastic lymphadenopathy (AIL) is reported, who developed disease specific infiltration of the kidneys with progressive destruction of renal parenchyma leading to high grade renal insufficiency. This unusual organ manifestation of AIL has not been previously reported. By treatment with high dose prednisolone and intense supportive therapy the patient underwent complete remission of AIL with preservation of the remaining renal function. Clinical, laboratory and immunological data are given as well as a light and electron microscopic evaluation of the renal involvement.

Aged↗
PubMed1981

Electron microscopy findings in fetal organs after perfusion of the amniotic cavity with oxygenated fluorocarbon.

In 20 fetal rabbits a double-blind electron microscopy study of placenta, lung, heart, liver, and stomach was performed at 28 or 29 days of gestation. The amniotic cavity was continuously perfused with perfluorotetrahydrofuran (FC 77) before the fetuses were killed. Compared with control fetuses, no morphological changes of fetal lung and stomach nor of placenta related to FC were found. There were unexplained changes in liver parenchymal cells. However, a protective effect of FC on the myocardial tissue was observed.

Animals↗
PubMed1981

[Animal experiments concerning the autoimplantation of splenic tissue (author's transl)].

15 male rabbits were divided into three groups. The animals in group 1 were splenectomized. In group 2 pulpa tissue from the cut surface of the spleen was left in the abdominal cavity. Group 3 was sham operated. After 15 months all animals from group 2 showed particles of histologically intact splenic tissue mainly on the parietal peritoneum of the abdominal wall. The implications of the autoimplantation of splenic tissue during splenectomy are discussed.

Animals↗